Comment on the Article "Analysis of the Incidence of Solid Cancer among Atomic Bomb Survivors Using a Two-Stage Model of Carcinogenesis" by M. Kai, E. G. Luebeck and S. H. Moolgavkar (Radiat. Res. 148, 348-358, 1997)

1998 ◽  
Vol 149 (3) ◽  
pp. 308
Author(s):  
Claire D. Sherman
Keyword(s):  
Atomic Bomb ◽  
Solid Cancer ◽  
Stage Model ◽  
Two Stage ◽  
Atomic Bomb Survivors ◽  
Article Analysis

Analysis of the Incidence of Solid Cancer among Atomic Bomb Survivors Using a Two-Stage Model of Carcinogenesis

1997 ◽  
Vol 148 (4) ◽  
pp. 348 ◽  
Author(s):  
Michiaki Kai ◽  
E. Georg Luebeck ◽  
Suresh H. Moolgavkar
Keyword(s):  
Atomic Bomb ◽  
Solid Cancer ◽  
Stage Model ◽  
Two Stage ◽  
Atomic Bomb Survivors

scholarly journals Risk of cancer associated with low-dose radiation exposure: comparison of results between the INWORKS nuclear workers study and the A-bomb survivors study

2021 ◽  
Vol 60 (1) ◽  
pp. 23-39
Author(s):  
Klervi Leuraud ◽  
David B. Richardson ◽  
Elisabeth Cardis ◽  
Robert D. Daniels ◽  
Michael Gillies ◽  
...  
Keyword(s):  
Low Dose ◽  
Atomic Bomb ◽  
Absolute Risk ◽  
Joint Analysis ◽  
Solid Cancer ◽  
Atomic Bomb Survivors ◽  
Nuclear Workers ◽  
Long Term Follow Up ◽  
Primary Basis ◽  
Risk Of Cancer

AbstractThe Life Span Study (LSS) of Japanese atomic bomb survivors has served as the primary basis for estimates of radiation-related disease risks that inform radiation protection standards. The long-term follow-up of radiation-monitored nuclear workers provides estimates of radiation-cancer associations that complement findings from the LSS. Here, a comparison of radiation-cancer mortality risk estimates derived from the LSS and INWORKS, a large international nuclear worker study, is presented. Restrictions were made, so that the two study populations were similar with respect to ages and periods of exposure, leading to selection of 45,625 A-bomb survivors and 259,350 nuclear workers. For solid cancer, excess relative rates (ERR) per gray (Gy) were 0.28 (90% CI 0.18; 0.38) in the LSS, and 0.29 (90% CI 0.07; 0.53) in INWORKS. A joint analysis of the data allowed for a formal assessment of heterogeneity of the ERR per Gy across the two studies (P = 0.909), with minimal evidence of curvature or of a modifying effect of attained age, age at exposure, or sex in either study. There was evidence in both cohorts of modification of the excess absolute risk (EAR) of solid cancer by attained age, with a trend of increasing EAR per Gy with attained age. For leukemia, under a simple linear model, the ERR per Gy was 2.75 (90% CI 1.73; 4.21) in the LSS and 3.15 (90% CI 1.12; 5.72) in INWORKS, with evidence of curvature in the association across the range of dose observed in the LSS but not in INWORKS; the EAR per Gy was 3.54 (90% CI 2.30; 5.05) in the LSS and 2.03 (90% CI 0.36; 4.07) in INWORKS. These findings from different study populations may help understanding of radiation risks, with INWORKS contributing information derived from cohorts of workers with protracted low dose-rate exposures.

Studies of Mortality of Atomic Bomb Survivors. Report 13: Solid Cancer and Noncancer Disease Mortality: 1950–1997

2012 ◽  
Vol 178 (2) ◽  
pp. AV146-AV172 ◽  
Author(s):  
Dale L. Preston ◽  
Yukiko Shimizu ◽  
Donald A. Pierce ◽  
Akihiko Suyama ◽  
Kiyohiko Mabuchi
Keyword(s):  
Atomic Bomb ◽  
Solid Cancer ◽  
Atomic Bomb Survivors ◽  
Disease Mortality

Studies of Mortality of Atomic Bomb Survivors. Report 13: Solid Cancer and Noncancer Disease Mortality: 1950–1997

2003 ◽  
Vol 160 (4) ◽  
pp. 381-407 ◽  
Author(s):  
Dale L. Preston ◽  
Yukiko Shimizu ◽  
Donald A. Pierce ◽  
Akihiko Suyama ◽  
Kiyohiko Mabuchi
Keyword(s):  
Atomic Bomb ◽  
Solid Cancer ◽  
Atomic Bomb Survivors ◽  
Disease Mortality

Reply to the Comments by Mortazavi and Doss on “Solid Cancer Incidence among the Life Span Study of Atomic Bomb Survivors: 1958–2009” (Radiat Res 2017; 187:513–537)

2017 ◽  
Vol 188 (3) ◽  
pp. 370-371 ◽  
Author(s):  
Eric J. Grant ◽  
Alina Brenner ◽  
Hiromi Sugiyama ◽  
Ritsu Sakata ◽  
Atsuko Sadakane ◽  
...  
Keyword(s):  
Life Span ◽  
Cancer Incidence ◽  
Atomic Bomb ◽  
Solid Cancer ◽  
Life Span Study ◽  
Atomic Bomb Survivors

scholarly journals Effect of Heterogeneity in Background Incidence on Inference about the Solid-Cancer Radiation Dose Response in Atomic Bomb Survivors

2019 ◽  
Vol 192 (4) ◽  
pp. 388 ◽  
Author(s):  
John Cologne ◽  
Jaeyoung Kim ◽  
Hiromi Sugiyama ◽  
Benjamin French ◽  
Harry M. Cullings ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Dose Response ◽  
Atomic Bomb ◽  
Solid Cancer ◽  
Atomic Bomb Survivors

scholarly journals Solid Cancer Incidence among the Life Span Study of Atomic Bomb Survivors: 1958–2009

2017 ◽  
Vol 187 (5) ◽  
pp. 513-537 ◽  
Author(s):  
Eric J. Grant ◽  
Alina Brenner ◽  
Hiromi Sugiyama ◽  
Ritsu Sakata ◽  
Atsuko Sadakane ◽  
...  
Keyword(s):  
Life Span ◽  
Cancer Incidence ◽  
Atomic Bomb ◽  
Solid Cancer ◽  
Life Span Study ◽  
Atomic Bomb Survivors
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