Live Polio Virus Vaccine

1959 ◽  
Vol 76 (5) ◽  
pp. 74
Author(s):  
Helen Buechl
Keyword(s):  
Virus Vaccine ◽  
Polio Virus

Polio Vaccination in Developing Countries

PEDIATRICS ◽  
1971 ◽  
Vol 48 (4) ◽  
pp. 667-668
Author(s):  
Roy E. Brown ◽  
Michael Katz
Keyword(s):  
Developing Countries ◽  
Virus Vaccine ◽  
Excretion Rate ◽  
Polio Virus ◽  
Vaccine Trials ◽  
Letter To The Editor ◽  
Polio Vaccination

We have recently come across the Letter to the Editor from Dr. Shanti Ghosh,1 commenting on the trivalent oral polio virus vaccine trials reported by Hardy, et al. in Pediatrics.2 Although 96 to 100% of infants demonstrated satisfactory levels of immunity in Hardy's group, using a microneutralization titer technique, Dr. Ghosh describes disappointing results in children in India and Nigeria as indicated by low seroconversion rates, as well as very low enterovirus excretion rate in pre- and postimmunization specimens (7.8%).

Letter To The Editor

PEDIATRICS ◽  
1996 ◽  
Vol 98 (4) ◽  
pp. 795-795
Author(s):  
Sanford Schneider
Keyword(s):  
Virus Vaccine ◽  
Limited Resources ◽  
Single Product ◽  
Live Virus ◽  
Polio Virus ◽  
Live Virus Vaccine ◽  
Letter To The Editor ◽  
Large Populations ◽  
The Cost ◽  
Cost Of Protection

The pro and con commentaries by Drs Judelsohn and Katz (Pediatrics 1996;98:115-117) do not mention projected costs. In these days of limited resources, the greatest bang for the buck is important and perhaps is becoming the most important factor of delivery of medical services to large populations. Developing a single product multi-vaccine containing inactivated polio virus, to be followed by oral live virus vaccine, will unquestionably add to the cost of protection. Also, Dr Katz does not seem to address the problem of compliance.

Trivalent Oral Polio Vaccine: Disappointing Results

PEDIATRICS ◽  
1971 ◽  
Vol 47 (3) ◽  
pp. 632-633
Author(s):  
Shanti Ghosh
Keyword(s):  
Virus Vaccine ◽  
Oral Polio Vaccine ◽  
Polio Virus ◽  
Tropical Countries ◽  
Polio Vaccine ◽  
Vaccine Trials ◽  
Baby Clinic

I was interested to read the paper on trivalent oral polio virus vaccine trials by Hardy and colleagues in your journal of March 1970,1 which reached here only recently. It prompts me to state the results we have achieved in the babies attending the Well Baby Clinic, who received three doses of trivalent oral polio vaccine at 4 to 6 weeks interval beginning at 3 to 6 months of age.2 Our results are disappointing and compare with the results achieved in some other tropical countries, particularly Nigeria.

scholarly journals Potency status of oral polio virus vaccine among retrieved field samples in Kenya

2014 ◽  
Vol 21 ◽  
pp. 441
Author(s):  
J.A. Hassan ◽  
G. Gachara ◽  
F. Mbugua ◽  
J. Muchiri ◽  
S. Symekhah ◽  
...  
Keyword(s):  
Virus Vaccine ◽  
Polio Virus ◽  
Field Samples

Poliovaccine Policy—Time for a Change

PEDIATRICS ◽  
1996 ◽  
Vol 98 (1) ◽  
pp. 116-117
Author(s):  
Samuel L. Katz
Keyword(s):  
United States ◽  
Cell Culture ◽  
Virus Vaccine ◽  
Field Trial ◽  
Marked Reduction ◽  
The United States ◽  
Polio Virus ◽  
Culture Systems ◽  
Cell Culture Systems ◽  
History Of

The history of the elimination of polio from the United States began in 1949 with the landmark achievement by Enders, Robbins, and Weller of the isolation and growth of polioviruses in cell culture systems. Within 5 years, Jonas Salk had developed and successfully tested his inactivated polio virus vaccine (IPV) incorporating all three serotypes in a formalin-heat inactivated preparation. After the successful Francis Field trial in April 1955, widespread programs for immunization were begun throughout the United States. Over the succeeding 4 years the success in marked reduction of polio each summer and autumn resulted in annual totals of fewer than 2000 paralytic patients in contrast to the previous tolls of 25 000 each year.

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