Case Report of Primary Rectal Melanoma and Review of the Etiology of Melanoma

2008 ◽  
Vol 12 (3) ◽  
pp. 117-120 ◽  
Author(s):  
Lauren Fratesi ◽  
Raed Alhusayen ◽  
James Walker
Keyword(s):  
Case Report ◽  
Immunohistochemical Staining ◽  
Anal Verge ◽  
Primary Melanoma ◽  
Rectal Mucosa ◽  
Sun Exposure ◽  
Lower Gastrointestinal Bleeding ◽  
Abdominal Discomfort ◽  
Virus Infections ◽  
Rectal Melanoma

Background: Primary rectal melanoma is a very rare and aggressive malignancy. It is defined as melanoma arising in the rectal mucosa, more than 4 cm from the anal verge. Objective: A case of primary rectal melanoma is reported, and the theories of the etiology of melanoma are reviewed. Methods and Results: This article reports a case of a 75-year-old woman who presented with lower gastrointestinal bleeding and abdominal discomfort. A polyp was removed from the low-lying rectum during colonoscopy. After immunohistochemical staining and microscopic examination, it was diagnosed as melanoma. Conclusion: In light of primary melanoma in sun-shielded regions such as the rectum, theories of causation other than sun exposure merit consideration. Factors such as genetics, immunosuppression, and virus infections, as well as ultraviolet radiation, may play a role in the etiology of melanoma.

An Obscure Colon Dilatation and its Underlying Cause: Case Report and Literature Review

2020 ◽  
pp. 1-5
Author(s):  
Anton Stift ◽  
Kerstin Wimmer ◽  
Felix Harpain ◽  
Katharina Wöran ◽  
Thomas Mang ◽  
...  
Keyword(s):  
Case Report ◽  
Sigmoid Colon ◽  
Immunohistochemical Staining ◽  
Late Onset ◽  
Hirschsprung Disease ◽  
Endoscopic Examination ◽  
Case Presentation ◽  
Idiopathic Megacolon ◽  
History Of ◽  
Cells Of Cajal

Introduction: Congenital as well as acquired diseases may be responsible for the development of a megacolon. In adult patients, Clostridium difficile associated infection as well as late-onset of Morbus Hirschsprung disease are known to cause a megacolon. In addition, malignant as well as benign colorectal strictures may lead to intestinal dilatation. In case of an idiopathic megacolon, the underlying cause remains unclear. Case Presentation: We describe the case of a 44-year-old male patient suffering from a long history of chronic constipation. He presented himself with an obscurely dilated large intestine with bowel loops up to 17 centimeters in diameter. Radiological as well as endoscopic examination gave evidence of a spastic process in the sigmoid colon. The patient was treated with a subtotal colectomy and the intraoperative findings revealed a stenotic stricture in the sigmoid colon. Since the histological examination did not find a conclusive reason for the functional stenosis, an immunohistochemical staining was advised. This showed a decrease in interstitial cells of Cajal (ICC) in the stenotic part of the sigmoid colon. Discussion: This case report describes a patient with an idiopathic megacolon, where the underlying cause remained unclear until an immunohistochemical staining of the stenotic colon showed a substantial decrease of ICCs. Various pathologies leading to a megacolon are reviewed and discussed.

Extensive Perivillous Fibrin and Intervillous Histiocytosis in a SARS-CoV-2 Infected Placenta From an Uninfected Newborn: A Case Report Including Immunohistochemical Profiling

2021 ◽  
pp. 109352662110251
Author(s):  
James Roberts ◽  
Jeanette D Cheng ◽  
Elizabeth Moore ◽  
Carla Ransom ◽  
Minhui Ma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Report ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Immunohistochemical Staining ◽  
Placental Pathology ◽  
Fibrin Deposition ◽  
Placental Infection ◽  
Fetal Infection

Placental infection by SARS-CoV-2 with various pathologic alterations reported. Inflammatory findings, such as extensive perivillous fibrin deposition and intervillous histiocytosis, have been postulated as risk factors for fetal infection by SARS-CoV-2. We describe the placental findings in a case of a 31-year-old mother with SARS-CoV-2 infection who delivered a preterm female neonate who tested negative for SAR-CoV2 infection. Placental examination demonstrated a small for gestational age placenta with extensive intervillous histiocytosis, syncytiotrophoblast karyorrhexis, and diffuse intervillous fibrin deposition. Immunohistochemical staining demonstrated infection of the syncytiotrophoblasts by SARS-CoV-2 inversely related to the presence of intervillous histiocytes and fibrin deposition. Our case demonstrates that despite extensive placental pathology, no fetal transmission of SARS-CoV-2 occurred, as well as postulates a relationship between placental infection, inflammation, and fibrin deposition.

scholarly journals Colorectal intussusception secondary to primary rectal melanoma: A novel case report

2018 ◽  
Vol 44 ◽  
pp. 78-81
Author(s):  
Colin McQuade ◽  
Peadar S. Waters ◽  
Ciara O’Brien ◽  
Stephen Crowther ◽  
William Torreggiani ◽  
...  
Keyword(s):  
Case Report ◽  
Rectal Melanoma

scholarly journals Cecum Dieulafoy’s Lesion Presenting with Recurrent Lower Gastrointestinal Bleeding: Case Report

2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Ludmila Resende Guedes ◽  
Silas Castro de Carvalho ◽  
Vitor Nunes Arantes ◽  
Arthur Manoel Braga de Albuquerque Gomes ◽  
Daniel Antônio de Albuquerque Terra ◽  
...  
Keyword(s):  
Case Report ◽  
Gastrointestinal Bleeding ◽  
Lower Gastrointestinal Bleeding ◽  
Dieulafoy’S Lesion

scholarly journals Anorectal Gastrointestinal Stromal Tumour: A Case Treated with Radical Surgery

2018 ◽  
Vol 16 (1) ◽  
pp. 99-101
Author(s):  
Arbin Joshi
Keyword(s):  
Case Report ◽  
Radical Surgery ◽  
Anal Verge ◽  
Gastrointestinal Stromal Tumour ◽  
Stromal Tumour ◽  
Rare Entity ◽  
Good Recovery ◽  
Rectal Pain ◽  
Close Proximity ◽  
Firm Mass

Gastrointestinal Stromal Tumour involving rectum and anal canal is an extremely rare entity. This is a case report of a 47 years lady presented with fresh rectal bleed associated with rectal pain and foul smelling rectal mucus discharge. On rectal examination, she had a firm mass palpable about 1.5 cm from anal verge. Considering the size of the tumour and its close proximity with cervix and involvement of levator muscles, extralevator abdominal perineal excision of rectum was undertaken with good recovery after surgery. It was followed by imatinib therapy.

scholarly journals Exogenous ochronosis: case report and literature review

2012 ◽  
Vol 87 (4) ◽  
pp. 633-636 ◽  
Author(s):  
Viviane Maria Rocha Martins ◽  
Antônio Renê Diógenes de Sousa ◽  
Natália de Carvalho Portela ◽  
Celina Aguiar Frota Tigre ◽  
Lucidi Maria Saraiva Gonçalves ◽  
...  
Keyword(s):  
United States ◽  
Case Report ◽  
Literature Review ◽  
South African ◽  
Practical Problem ◽  
Sun Exposure ◽  
Tropical Climate ◽  
The United States ◽  
African Population ◽  
South African Population

Exogenous ochronosis is a rare, cosmetically disfiguring condition, resulting from the longterm use of topical hydroquinone in treatment of melasma. It manifests as gray-brown or blue-black macules in hydroquinone-exposed regions. The exact incidence of ochronosis is unknown. High rates have been reported in the South African population, and it is rare in the United States. We report the case of a patient who developed exogenous ochronosis while using topical hydroquinone. It is necessary to recognize this disorder at the earliest stage and discontinue hydroquinone immediately, as its treatment is difficult. Sun exposure facilitates the formation of exogenous ochronosis and must be strictly avoided, although it is a practical problem in the tropical climate of Brazil, particularly for those who work outdoors.

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