scholarly journals Contribution of different adherent properties of Granulicatella adiacens and Abiotrophia defectiva to their associations with oral colonization and the risk of infective endocarditis

2020 ◽  
Vol 62 (1) ◽  
pp. 36-39 ◽  
Author(s):  
Minoru Sasaki ◽  
Yu Shimoyama ◽  
Taichi Ishikawa ◽  
Yoshitoyo Kodama ◽  
Shihoko Tajika ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Abiotrophia Defectiva ◽  
Granulicatella Adiacens ◽  
Oral Colonization

scholarly journals Atypical presentation of Abiotrophia defectiva infective endocarditis in an octogenarian

2020 ◽  
Author(s):  
Gerard Forde ◽  
Mary Lucey ◽  
Paula M. O'Shea ◽  
Julie Okiro ◽  
Ramadan Shatwan ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Atypical Presentation ◽  
Abiotrophia Defectiva

scholarly journals Novel double beta-lactam therapy for Granulicatella adiacens infective endocarditis

IDCases ◽  
2021 ◽  
Vol 24 ◽  
pp. e01082
Author(s):  
S. Khan ◽  
C. Urban ◽  
V. Singh ◽  
D. Liu ◽  
S. Segal-Maurer ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Beta Lactam ◽  
Granulicatella Adiacens

scholarly journals Quadruple-valve infective endocarditis caused by Abiotrophia defectiva

2017 ◽  
Vol 25 (6) ◽  
pp. 998-999 ◽  
Author(s):  
Mislav Planinc ◽  
Marko Kutlesa ◽  
Bruno Barsic ◽  
Igor Rudez
Keyword(s):  
Infective Endocarditis ◽  
Abiotrophia Defectiva

scholarly journals Antimicrobial Susceptibilities of Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans

2015 ◽  
Vol 60 (3) ◽  
pp. 1411-1420 ◽  
Author(s):  
Michael O. Alberti ◽  
Janet A. Hindler ◽  
Romney M. Humphries
Keyword(s):  
Antimicrobial Susceptibility ◽  
Susceptibility Testing ◽  
16S Rrna Gene Sequencing ◽  
Species Level ◽  
Rrna Gene ◽  
Content Type ◽  
Susceptibility Data ◽  
Abiotrophia Defectiva ◽  
Granulicatella Adiacens ◽  
Level Identification

Nutritionally variant streptococci (NVS) are fastidious Gram-positive cocci comprised of the speciesAbiotrophia defectiva,Granulicatella adiacens, andGranulicatella elegans. NVS are an important cause of bacteremia and infective endocarditis (IE) associated with significant morbidity and mortality. Antimicrobial susceptibility testing (AST) was performed for 14 antimicrobials using the broth microdilution MIC method described in the Clinical and Laboratory Standards Institute (CLSI) M45 guideline. A total of 132 clinical NVS blood isolates collected from 2008 to 2014 were tested. Species level identification of NVS isolates was achieved by 16S rRNA gene sequencing and/or matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS). Ninety isolates were identified asG. adiacens, 37 asA. defectiva, and 5 asG. elegans. All isolates were susceptible to vancomycin (MIC90= 1 μg/ml), and none displayed high-level resistance to aminoglycosides.G. adiacenswas considerably more susceptible to penicillin thanA. defectiva(38.9% versus 10.8% of isolates susceptible) but was less susceptible to cephalosporins than wasA. defectiva(43.3% versus 100% of isolates susceptible to ceftriaxone). Several isolates were resistant to levofloxacin (6%), erythromycin (51%), and clindamycin (10%). The MIC90for daptomycin was ≥4 μg/ml forG. adiacensandA. defectiva.G. elegansisolates were 100% susceptible to all antimicrobials tested, with the exception of erythromycin, to which only 20% were susceptible. This study provides antimicrobial susceptibility data for a recent collection of NVS and demonstrates important NVS species-related differences with respect to susceptibility to penicillin, cephalosporins, carbapenems, and daptomycin. Species-level identification of NVS organisms when susceptibility testing is not readily available may aid in treatment decisions.

A case of isolated tricuspid valve infective endocarditis caused by Abiotrophia defectiva

2007 ◽  
Vol 118 (1) ◽  
pp. e3-e5 ◽  
Author(s):  
Reiko Takayama ◽  
Munenobu Motoyasu ◽  
Tetsuya Seko ◽  
Kenji Kuroda ◽  
Takashi Yamanaka ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Tricuspid Valve ◽  
Abiotrophia Defectiva

scholarly journals Atypical presentation of Abiotrophia defectiva infective endocarditis in an octogenarian

2020 ◽  
Author(s):  
Gerard Forde ◽  
Mary Lucey ◽  
Paula O Shea ◽  
Ramadan Shatwan ◽  
Julie Okiro ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Atypical Presentation ◽  
Abiotrophia Defectiva

scholarly journals Aortic Valve Replacement and Penicillin Desensitization in a Patient with Abiotrophia defectiva Aortic Valve Endocarditis

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
S. Kumar ◽  
S. Mahmood ◽  
A. Madras ◽  
A. Iyer
Keyword(s):  
Infective Endocarditis ◽  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Antibiotic Therapy ◽  
Valve Replacement ◽  
Bicuspid Aortic Valve ◽  
Positive Outcome ◽  
Valvular Regurgitation ◽  
Abiotrophia Defectiva ◽  
Echocardiographic Evidence

Abiotrophia defectiva is an uncommon and insidious yet destructive cause of infective endocarditis preferentially treated with penicillin/gentamicin and often requiring surgical treatment. A 60-year-old man with penicillin anaphylaxis history presented with fevers and a nonspecific constellation of symptoms. He was ultimately diagnosed with bicuspid aortic valve infective endocarditis based on blood cultures growing A.defectiva and echocardiographic evidence of bicuspid aortic valve, severe valvular regurgitation, and 5 × 7   mm vegetation. Aortic valve replacement and culture yielded penicillin-sensitive A.defectiva. After successful penicillin desensitization, antibiotic therapy was switched from vancomycin/gentamicin to benzylpenicillin. This is the first published case of penicillin desensitization in a patient with A.defectiva-associated infection. Penicillin desensitization, optimal antibiotic therapy, prompt aortic valve replacement, and close collaboration between cardiology and various other specialties were essential in achieving a positive outcome.

scholarly journals Granulicatella adiacens and Abiotrophia defectiva Native Vertebral Osteomyelitis: Three Cases and Literature Review of Clinical Characteristics and Treatment Approach

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Cinzia Puzzolante ◽  
Gianluca Cuomo ◽  
Marianna Meschiari ◽  
Andrea Bedini ◽  
Aurora Bonazza ◽  
...  
Keyword(s):  
Clinical Cure ◽  
Treatment Duration ◽  
Clinical Characteristics ◽  
Treatment Approach ◽  
Vertebral Osteomyelitis ◽  
Empirical Therapy ◽  
Osteoarticular Infections ◽  
Abiotrophia Defectiva ◽  
Granulicatella Adiacens ◽  
Resistant Strains

Granulicatella adiacens and Abiotrophia defectiva are an increasingly recognized cause of osteoarticular infections. We describe two cases of G. adiacens and one case of A. defectiva native vertebral osteomyelitis (NVO) and review all published cases. Nine cases of G. adiacens NVO and two cases of A. defectiva NVO were previously described. Patients were usually middle-aged men, and classical risk factors for NVO were present in half of the cases. Concomitant bacteremia was reported in 78.6% of cases, and concurrent infective endocarditis occurred in 36.4% of this sub-group of patients. Many different antibiotic schemes were recorded, with median treatment duration of 6 weeks. In the most recent reports, glycopeptides represented the most frequent empirical therapy, possibly due to the increasing emergence of G. adiacens and A. defectiva penicillin-resistant strains. Stabilization surgery was rarely required (14.3% of cases), and clinical cure was generally achieved. In conclusion, Granulicatella spp. and Abiotrophia spp. NVO is rare but increasingly described. A total antibiotic course of six weeks seems to be appropriate for noncomplicated cases, and clinical outcome is generally favorable.

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