Superconductivity in Carbonaceous Sulfur Hydride: Further Analysis of Relation between Published AC Magnetic Susceptibility Data and Measured Raw Data

In arXiv:2111.15017v1 [1], Dias and Salamat posted some of the measured data for ac magnetic susceptibility of carbonaceous sulfur hydride, a material that was reported in Nature 586, 373 (2020) [2] to be a room temperature superconductor. They provided additional measured data in arXiv:2111.15017v2 [3]. Here I provide an analysis of these data. The results of this analysis indicate that the claim of ref. [2] that magnetic susceptibility measurements support the conclusion that the material is a room temperature superconductor is not supported by valid underlying data.

New Insights into Interpretation of Aeromagnetic Data for Distribution of Igneous Rocks in Central Iran

—New insights in the aeromagnetic data over the Central Iranian Microcontinent (CIM) have revealed interesting results for future studies and exploration. This work presents the interpretation of different magnetic analyses and the calculated 3D inversion model to provide important insights into the distribution of igneous rocks in the area that may be traced under significant cover. By analyzing several hundred magnetic susceptibility data points and aeromagnetic anomalies of known igneous rocks over the area, it was determined that mafic–ultramafic intrusive rocks generally have a high magnetic susceptibility and produce a strong magnetic response. Intermediate–felsic intrusive rocks have a low magnetic susceptibility and show a smooth gradient variation and commonly regular shape. Volcanic rocks show a wide range of magnetic susceptibility; therefore, the aeromagnetic anomalies are often random or show strong amplitude with high frequency signals and are rapidly eliminated when an upward continuation is applied. Based on the results of analysis of different magnetic maps and 3D inversion of data, and combining this information with known outcropped of igneous rocks, we revealed 1215 concealed intrusive rocks and 528 volcanic rocks in the area. We also renewed the boundaries of tens outcropped igneous rocks. The known and new mapped igneous rocks can be identified as 12 regions (or zones) for intrusive rocks and 4 regions for volcanic rocks. The results indicate that the mafic–ultramafic rocks are mainly located in the Sistan suture zone of eastern Iran along the Nehbandan fault zone. They also show that the many parts of the Lut block as the main structure of CIM have been under magmatic events, so that most of concealed igneous rocks are distributed in the middle and southern part of the Lut block. Volcanic rocks are widespread in the southeastern and northern parts of the area such as the Urumieh-Dokhtar Magmatic Arc, North Lut, and Bam region.

Single-dose pharmacokinetics of orally administered terbinafine in bearded dragons (Pogona vitticeps) and the antifungal susceptibility patterns of Nannizziopsis guarroi

OBJECTIVE To identify the antifungal susceptibility of Nanniziopsis guarroi isolates and to evaluate the single-dose pharmacokinetics of orally administered terbinafine in bearded dragons. ANIMALS 8 healthy adult bearded dragons. PROCEDURES 4 isolates of N guarroi were tested for antifungal susceptibility. A compounded oral solution of terbinafine (25 mg/mL [20 mg/kg]) was given before blood (0.2 mL) was drawn from the ventral tail vein at 0, 4, 8, 12, 24, 48, 72, and 96 hours after administration. Plasma terbinafine concentrations were measured with high-performance liquid chromatography. RESULTS The antifungal minimum inhibitory concentrations against N guarroi isolates ranged from 4,000 to > 64,000 ng/mL for fluconazole, 125 to 2,000 ng/mL for itraconazole, 125 to 2,000 ng/mL for ketoconazole, 125 to 1,000 ng/mL for posaconazole, 60 to 250 ng/mL for voriconazole, and 15 to 30 ng/mL for terbinafine. The mean ± SD peak plasma terbinafine concentration in bearded dragons was 435 ± 338 ng/mL at 13 ± 4.66 hours after administration. Plasma concentrations remained > 30 ng/mL for > 24 hours in all bearded dragons and for > 48 hours in 6 of 8 bearded dragons. Mean ± SD terminal half-life following oral administration was 21.2 ± 12.40 hours. CLINICAL RELEVANCE Antifungal susceptibility data are available for use in clinical decision making. Results indicated that administration of terbinafine (20 mg/kg, PO, q 24 to 48 h) in bearded dragons may be appropriate for the treatment of dermatomycoses caused by N guarroi. Clinical studies are needed to determine the efficacy of such treatment.

Incompatibility of Published ac Magnetic Susceptibility of a Room Temperature Superconductor with Measured Raw Data

Room temperature superconductivity has recently been reported for a carbonaceous sulfur hydride (CSH) under high pressure by Snider et al [1]. The paper reports sharp drops in magnetic susceptibility as a function of temperature for five different pressures, that are interpreted as signaling a superconducting transition. Here I question the validity and faithfulness of the magnetic susceptibility data presented in the paper by comparison with the measured raw data reported by two of the authors of ref. [2]. This invalidates the assertion of the paper [1] that the susceptibility measurements support the case for superconductivity in this compound.

Identification of shapes and uses of past landscapes through EMI survey

Over the last ten years, the use of Electro-Magnetic Induction (EMI) instruments for archaeological purposes has increased considerably. This development has come both from the availability of new instruments' with multi-coils spacing allowing a multi-depth analysis and because of the wide availability of high quality GPS positing which can be easily integrated with EMI. These new pos- sibilities promote the use of EMI instruments for the study of archaeological landscapes and sites. Indeed, the capability to simultane- ously map both the electrical conductivity and the magnetic susceptibility presents a great advantage for archaeological purposes com- pared to other geophysical instruments. The combination of these two measurements means that it is possible to geomorphologicaly characterize past landscapes while simultaneously mapping anthropogenic activities. 7b maximize the potential ofE MI measurements, this technique requires specialized processing and calibration to limit confusing and unclear results. In order to obtain quantitative conductivity and magnetic susceptibility data, it is necessary to correct instrumental drift and calibrate for local soil conditions. In this paper we introduce the theoretical basis of the EMI technique, discuss common instruments and explain the calibration procedure before presenting three case studies that illustrate applications of EMI to archaeological sites on a range of scales.

Beating standard quantum limit via two-axis magnetic susceptibility measurement

We report a metrology scheme which measures magnetic susceptibility of an atomic spin ensemble along the x and z direction and produces parameter estimation with precision beating the standard quantum limit. The atomic ensemble is initialized via one-axis spin squeezing with optimized squeezing time and parameter φ to be estimated is assumed as uniformly distributed between 0 and 2π, while fixed in each estimation. One estimation of φ can be produced with every two magnetic susceptibility data measured along the two axis respectively, which has imprecision scaling (1.43 ± 0.02)/N 0.687±0.003 with respect to the number N of atomic spins. The measurement scheme is easy to implement and is robust against measurement fluctuation caused by environment noise and measurement defects.

Incompatibility of Published ac Magnetic Susceptibility of a Room Temperature Superconductor with Measured Raw Data

Room temperature superconductivity has recently been reported for a carbonaceous sulfur hydride (CSH) under high pressure by Snider et al [1]. The paper reports sharp drops in magnetic susceptibility as a function of temperature for five different pressures, that are interpreted as signaling a superconducting transition. Here I question the validity and faithfulness of the magnetic susceptibility data presented in the paper by comparison with the measured raw data reported by two of the authors of ref. [2]. This casts doubt on the assertion of the paper [1] that the susceptibility measurements support the case for superconductivity in this compound.

Antifungal susceptibility profile of invasive Candida glabrata isolates (2009–2020) from a tertiary care hospital laboratory in Pakistan

Introduction. Invasive infections with Candida glabrata are a global concern due to poor clinical outcomes and propensity to acquire resistance to antifungal agents. Hypothesis/Gap Statement. Monitoring emerging resistance and trends in Candida glabrata, an important agent of candidemia in Pakistan, is critical for patient management; data that is missing from Pakistan. Aim. Thus, this study evaluated antifungal resistance and MICs) distribution in invasive C. glabrata isolates from Pakistan. Methods. This cross-sectional and retrospective study was conducted from January 2009 to March 2020 at a clinical laboratory in Pakistan that has a nation-wide network. Antifungal susceptibility data of 277 candidemia, deep organ and soft tissue (invasive) C. glabrata sensu lato isolates against fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, micafungin, caspofungin and amphotericin B was retrieved. Susceptibility testing was performed using colorimetric broth microdilution and interpreted using CLSI criteria. Demographics, clinical history and outcome were studied. Chi-square test was used to demonstrate association between antifungal resistance and clinical characteristics of the patients. Results. We identified 277 patients with invasive C. glabrata infection. Of which 48 (18.4%) isolates were resistant to fluconazole (MIC ≥64 mg l−1), one isolate each was resistant to amphotericin (MIC=2 mg l−1), anidulafungin (MIC=1 mg l−1) and micafungin (MIC=0.5 mg l−1). MIC90 for fluconazole was 64 mg l−1 and other triazoles 2 mg l−1, caspofungin 0.12 mg l−1, anidulafungin 0.06 mg l−1, micafungin 0.03 mg l−1 and amphotericin 0.5 mg l−1. Fluconazole MIC ≥64 mg l−1, caspofungin MIC >0.06 mg l−1 and amphotericin MIC >0.25 mg l−1 (above MIC50) were significantly associated with patient being alive at the time of reporting, no use of healthcare devices, nor infection with other fungi. Fluconazole resistance was significantly associated with prior antifungal use by the patient. Conclusion. Surveillance data of antifungal resistance among common Candida species should be monitored closely for identification of resistant strains.

Combination of pharmacokinetic and pathogen susceptibility information to optimize meropenem treatment of gram-negative infections in critically ill patients

Background: Meropenem is one of the most frequently used antibiotics to treat life-threatening infections in critically ill patients. This study aimed to develop a meropenem dosing algorithm for the treatment of gram-negative infections based on intensive care unit (ICU)-specific resistance data. Methods: Antimicrobial susceptibility testing of gram-negative bacteria obtained from critically ill patients was carried out from 2016 to 2020 at a tertiary care hospital. Based on the observed minimal inhibitory concentration (MIC) distribution, stochastic simulations (n=1000) of an evaluated pharmacokinetic meropenem model and a defined pharmacokinetic/pharmacodynamic target (100%T >4xMIC while minimum concentrations <44.5 mg/L), dosing recommendations for patients with varying renal function were derived: Pathogen-specific MIC distributions were used to calculate the cumulative fraction of response (CFR) and the overall MIC distribution was used to calculate the local pathogen-independent mean fraction of response (LPIFR) for the investigated dosing regimens. A CFR/LPIFR >90% was considered adequate. Results: The observed MIC distribution significantly differed from the EUCAST database. Based on the 6520 MIC values included, a three-level dosing algorithm was developed. If the pathogen causing the infection is unknown (level 1), known (level 2), known to be neither Pseudomonas aeruginosa nor Acinetobacter baumannii or classified as susceptible (level 3), a continuous infusion of 1.5 g daily reached sufficient target attainment independent of renal function. In all other cases dosing needs to be adjusted based on renal function. Conclusion: ICU-specific susceptibility data should be assessed regularly and integrated into dosing decisions. The presented workflow may serve as a blueprint for other antimicrobial settings. (250 words)

Microbiological characteristics of bacteremias among COVID-19 hospitalized patients in a tertiary referral hospital in Northern Greece during the second epidemic wave

ABSTRACT Northern Greece was struck by an intense second COVID-19 epidemic wave during the fall of 2020. Because of the coinciding silent epidemic of MDR organisms the handling of COVID-19 patients became even more challenging. In the present study, the microbiological characteristics of bacteraemias in confirmed cases of hospitalized COVID-19 patients were determined. Data from 1165 patients hospitalized between September and December 2020 were reviewed regarding the frequency of bloodstream infections, the epidemiology and the antibiotic susceptibility profiles of the causative bacteria. The hospital's antibiotic susceptibility data for all major nosocomial pathogens isolated from bacteremias of COVID-19 patients between September-December 2020 versus September-December 2019 bacteremias were also compared. Overall, 122 patients developed bacteremia (10.47%). The average of time interval between hospitalization date and development of bacteremia was 13.98 days. Admission to ICU occurred in 98 out of 122 patients with an average time of stay 15.85 days and 90.81% in-hospital mortality. In total, 166 pathogens were recovered including 114 Gram-negative bacteria and 52 Gram-positive cocci. Acinetobacter baumannii were the most frequent (n = 51) followed by Klebsiella pneumoniae (n = 45) and Enterococcus faecium (n = 31). Bacteremias in hospitalized COVID-19 patients were related with prolonged time of hospitalization and higher in-hospital mortality and the isolated microorganisms represented the bacterial species that were present in our hospital before the COVID-19 pandemic. Worryingly, the antibiotic resistance rates were increased compared to the pre-pandemic era for all major opportunistic bacterial pathogens. The pandemic highlighted the need for continuous surveillance of patients with prolonged hospitalization.