scholarly journals A Novel -192c/g Mutation in the Proximal P2 Promoter of the Hepatocyte Nuclear Factor-4  Gene (HNF4A) Associates With Late-Onset Diabetes

Diabetes ◽  
2006 ◽  
Vol 55 (6) ◽  
pp. 1869-1873 ◽  
Author(s):  
J. Ek ◽  
S. P. Hansen ◽  
M. Lajer ◽  
C. Nicot ◽  
T. W. Boesgaard ◽  
...  
Keyword(s):  
Late Onset ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Onset Diabetes ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4

scholarly journals A Hepatocyte Nuclear Factor-4  Gene (HNF4A) P2 Promoter Haplotype Linked With Late-Onset Diabetes: Studies of HNF4A Variants in the Norwegian MODY Registry

Diabetes ◽  
2006 ◽  
Vol 55 (6) ◽  
pp. 1899-1903 ◽  
Author(s):  
H. Raeder ◽  
L. Bjorkhaug ◽  
S. Johansson ◽  
K. Mangseth ◽  
J. V. Sagen ◽  
...  
Keyword(s):  
Late Onset ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Onset Diabetes ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4 ◽  
Promoter Haplotype

scholarly journals A missense mutation in the hepatocyte nuclear factor 4 alpha gene in a UK pedigree with maturity-onset diabetes of the young

Diabetologia ◽  
1997 ◽  
Vol 40 (7) ◽  
pp. 859-862 ◽  
Author(s):  
M. P. Bulman ◽  
M. J. Dronsfield ◽  
T. Frayling ◽  
M. Appleton ◽  
S. C. Bain ◽  
...  
Keyword(s):  
Missense Mutation ◽  
Nuclear Factor ◽  
Maturity Onset Diabetes ◽  
Hepatocyte Nuclear Factor ◽  
Onset Diabetes ◽  
Hepatocyte Nuclear Factor 4 ◽  
Alpha Gene

scholarly journals Hepatocyte Nuclear Factor-4  P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population

Diabetes ◽  
2006 ◽  
Vol 55 (5) ◽  
pp. 1260-1264 ◽  
Author(s):  
K. Hara ◽  
M. Horikoshi ◽  
H. Kitazato ◽  
C. Ito ◽  
M. Noda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Japanese Population ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4 ◽  
Promoter Haplotypes

scholarly journals Common Variants of the Hepatocyte Nuclear Factor-4  P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population

Diabetes ◽  
2004 ◽  
Vol 53 (11) ◽  
pp. 3002-3006 ◽  
Author(s):  
M. N. Weedon ◽  
K. R. Owen ◽  
B. Shields ◽  
G. Hitman ◽  
M. Walker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Common Variants ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4

scholarly journals Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance.

2011 ◽  
Vol 58 (2) ◽  
Author(s):  
Riyadh Saif-Ali ◽  
Roslan Harun ◽  
S Al-Jassabi ◽  
Wan Zurinah Wan Ngah
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Fasting Blood Glucose ◽  
Nuclear Factor ◽  
Nucleotide Polymorphisms ◽  
Hepatocyte Nuclear Factor ◽  
Coding Region ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4 ◽  
Hnf4 Alpha

This study aimed to investigate the associations of hepatocyte nuclear factor 4 (HNF4) alpha single nucleotide polymorphisms (SNPs) and haplotype with insulin resistance and metabolic syndrome parameters. Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. The HNF4 alpha P2 promoter SNPs rs4810424, rs1884613 and rs1884614 were associated with insulin resistance (p = 0.017; 0.037; 0.024) and body mass index (BMI) (p = 0.03; 0.035; 0.039). The intron 1D SNP rs2144908 was associated with high-density lipoprotein cholesterol (HDLc) (p = 0.020) and the intron 9 SNP rs3818247 showed association with systolic (p = 0.02) and diastolic (p = 0.034) blood pressure. HNF4 alpha common haplotype CCCGTC associated with higher insulin resistance (p = 0.022), fasting blood glucose (FBG) (p = 0.035) and lower HDLc (p = 0.001). In conclusion, subjects with HNF4 alpha P2 variants and haplotypes have been shown to have a higher insulin resistance and are therefore at a higher risk for developing type 2 diabetes mellitus.

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