scholarly journals Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients

Diabetes ◽  
2009 ◽  
Vol 58 (10) ◽  
pp. 2267-2276 ◽  
Author(s):  
R. Hilbrands ◽  
V. A.L. Huurman ◽  
P. Gillard ◽  
J. H.L. Velthuis ◽  
M. De Waele ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Islet Cell ◽  
Diabetic Patients ◽  
Islet Cell Transplantation ◽  
Type 1 Diabetic Patients

scholarly journals PANCREAS AND ISLET TRANSPLANTATION: CLINICAL INDICATIONS AND CLINICAL RESULTS

2006 ◽  
Author(s):  
Antonio Secchi
Keyword(s):  
Type 1 Diabetes ◽  
Cell Transplantation ◽  
Pancreas Transplantation ◽  
Islet Cell ◽  
Diabetic Patients ◽  
Islet Cell Transplantation ◽  
Insulin Independence ◽  
Related Complication ◽  
Diabetes Related Complication

Pancreas transplantation is the more effective cure for type 1 diabetes. Although intensive insulin scheme has been demonstrated to reduce the incidence of diabetes related complication, only pancreas transplantation normalizes glycometabolic control, avoids the risk of severe hypoglycemic events and prevents or in some case ameliorates diabetes related complications. In this review it will be analyzed the impact of pancreas transplantation on diabetes related complication and patient survival. Islet cell transplantation has recently emerged as one the most promising therapeutic approaches to improving glycometabolic control in type 1 diabetic patients and, in many cases, to obtaining insulin independence. Islet cell transplantation requires a relatively short hospital stay and has the advantage of being a relatively noninvasive procedure. The rate of insulin independence 1 year after islet cell transplantation has significantly improved in recent years Data from a recent international Trial confirmed that islet cell transplantation can be potentially a cure for type 1 diabetes. Recent data indicate that insulin independence after islet cell transplantation is associated with an improvement in glucose metabolism and quality of life and with a reduction in hypoglycemic episodes. Islet cell transplantation is still in its initial stages, and many obstacles still need to be overcome. Once clinical islet transplantation has been successfully established, this treatment could even be offered to diabetic patients long before the onset of diabetic complications or to patients with life-threatening hypoglycemic unawareness and brittle diabetes.

Islet cell transplantation for the treatment of type 1 diabetes in the USA

2008 ◽  
Vol 16 (2) ◽  
pp. 118-123 ◽  
Author(s):  
Tetsuya Ikemoto ◽  
Hirofumi Noguchi ◽  
Masayuki Shimoda ◽  
Bashoo Naziruddin ◽  
Andrew Jackson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cell Transplantation ◽  
Islet Cell ◽  
Islet Cell Transplantation ◽  
The Usa

scholarly journals Ambulatory intravenous insulin and islet cell transplantation to treat severe type III insulin hypersensitivity in a patient with type 1 diabetes mellitus

2020 ◽  
Vol 8 (12) ◽  
pp. 2759-2762
Author(s):  
Brigette Clarke ◽  
Tom Loudovaris ◽  
Toni Radford ◽  
Chris Drogemuller ◽  
Patrick Toby Coates ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Cell Transplantation ◽  
Islet Cell ◽  
Islet Cell Transplantation ◽  
Intravenous Insulin ◽  
Severe Type ◽  
Insulin Hypersensitivity

scholarly journals Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients

2015 ◽  
Vol 100 (6) ◽  
pp. 2314-2321 ◽  
Author(s):  
Zhidong Ling ◽  
Pieter De Pauw ◽  
Daniel Jacobs-Tulleneers-Thevissen ◽  
Rui Mao ◽  
Pieter Gillard ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Islet Cell ◽  
Cell Loss ◽  
Diabetic Patients ◽  
Islet Cell Transplantation ◽  
Β Cell

scholarly journals Modern technologies in management of diabetes

2017 ◽  
Vol 13 (2) ◽  
pp. 296-301
Author(s):  
Anbreen Iqbal ◽  
Muhammad Imran Qadir ◽  
Muhammad Asif
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cell Transplantation ◽  
Islet Cell ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Islet Cell Transplantation ◽  
Insulin Dependent

Diabetes is not one disease but rather is a heterogeneous group of syndromes characterized by an elevation of fasting blood glucose caused by a relative or absolute deficiency in insulin. The two main types of diabetes occur, type-1 is insulin dependent diabetes mellitus and type-2 is non insulin dependent diabetes mellitus. In type-1 body does not produce insulin and about 10% of all diabetic patients are affected. In type-2 diabetes imbalance of insulin and glucose occur and there are about 90% cases for type-2 diabetes. Gestational diabetes is also a type of diabetes and it is found mostly in women’s who are pregnant later such women’s are affected with type-2 diabetes and about 40% cases are studied. Different countries are affected at high level from diabetes. For the treatment of diabetes different techniques like insulin injection, oral vaccination, pancreas transplantation, transplantation of encapsulated islet cells, gene therapy technique and islet cell transplantation are used. All techniques have some advantages and disadvantages, but the encapsulated islet cell transplantation technique is promising with minimum complications. 

scholarly journals Coronary artery calcium may stabilize following islet cell transplantation in patients with type 1 diabetes

2017 ◽  
Vol 31 (10) ◽  
pp. e13059 ◽  
Author(s):  
Jessica M. Madrigal ◽  
Rebecca S. Monson ◽  
Betul Hatipoglu ◽  
José Oberholzer ◽  
George T. Kondos ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Cell Transplantation ◽  
Coronary Artery Calcium ◽  
Islet Cell ◽  
Islet Cell Transplantation
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