Safety and Efficacy of Sitagliptin (SITA) Compared with Dapagliflozin (DAPA) in Subjects with T2D, Mild Renal Impairment, and Inadequate Glycemic Control on Metformin (MET) ± a Sulfonylurea (SU)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1142-P
Author(s):  
RUSSELL S. SCOTT ◽  
JERRY D. MORGAN ◽  
ZACHARY ZIMMER ◽  
RAYMOND L.H. LAM ◽  
EDWARD A. O'NEILL ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Renal Impairment ◽  
Mild Renal Impairment ◽  
Safety And Efficacy ◽  
Inadequate Glycemic Control

Safety and efficacy of 5-azacytidine treatment in myelodysplastic syndrome patients with moderate and mild renal impairment

2013 ◽  
Vol 37 (8) ◽  
pp. 889-893 ◽  
Author(s):  
Evdoxia Douvali ◽  
Menelaos Papoutselis ◽  
Theodoros P. Vassilakopoulos ◽  
Vasileios Papadopoulos ◽  
Emmanouil Spanoudakis ◽  
...  
Keyword(s):  
Renal Impairment ◽  
Myelodysplastic Syndrome ◽  
Mild Renal Impairment ◽  
Safety And Efficacy

Anticoagulant dosing in renal impairment

Phlebologie ◽  
2015 ◽  
Vol 44 (06) ◽  
pp. 316-319 ◽  
Author(s):  
S. Harder
Keyword(s):  
Risk Factor ◽  
Venous Thromboembolism ◽  
Renal Impairment ◽  
Anticoagulant Therapy ◽  
Severe Renal Impairment ◽  
Dabigatran Etexilate ◽  
The Elderly ◽  
Thrombin Inhibitor ◽  
Safety And Efficacy ◽  
Direct Acting

SummaryAnticoagulants are widely used for prophylaxis and treatment of venous thromboembolism in the elderly, who commonly have renal impairment and other comorbidities. Renal impairment is a risk factor for bleeding and thrombosis during anticoagulant therapy and can influence the balance between the safety and efficacy of such agents. Some anticoagulants, such as fondaparinux and the direct acting oral thrombin inhibitor dabigatran etexilate are contraindicated for use in patients with severe renal impairment (eGFR <30 ml/min). However, also the direct acting oral FXa-inhibitors rivaroxaban, edoxaban and apixaban need caution regarding dosing advice or contraindications when used in patients with renal impairment.

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