Predictive Utilities of Blood Pressure Variables on Coronary Artery Disease in Type 1 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 161-OR
Author(s):  
JINGCHUAN GUO ◽  
TREVOR J. ORCHARD
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Artery Disease

scholarly journals Optimal Blood Pressure Thresholds for Minimal Coronary Artery Disease Risk in Type 1 Diabetes

Diabetes Care ◽  
2019 ◽  
Vol 42 (9) ◽  
pp. 1692-1699 ◽  
Author(s):  
Jingchuan Guo ◽  
Maria M. Brooks ◽  
Matthew F. Muldoon ◽  
Ashely I. Naimi ◽  
Trevor J. Orchard ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Disease Risk ◽  
Coronary Artery Disease Risk ◽  
Artery Disease ◽  
Optimal Blood Pressure

scholarly journals Prognostic Significance of Pulse Pressure and Other Blood Pressure Components for Coronary Artery Disease in Type 1 Diabetes

2019 ◽  
Vol 32 (11) ◽  
pp. 1075-1081 ◽  
Author(s):  
Jingchuan Guo ◽  
Matthew F Muldoon ◽  
Maria M Brooks ◽  
Trevor J Orchard ◽  
Tina Costacou
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Diastolic Blood Pressure ◽  
Pulse Pressure ◽  
Artery Disease

AbstractBACKGROUNDTo compare in individuals with type 1 diabetes the prediction of incident coronary artery disease (CAD) by components of resting blood pressure—systolic, diastolic, pulse pressure, and mean arterial pressure.METHODSIn 605 participants without known CAD at baseline and followed sequentially for 25 years, we used Cox modeling built for each blood pressure component associated with incident CAD, overall and stratified by age (<35 and ≥35 years) or hemoglobin A1c (HbA1c) (<9% and ≥9%).RESULTSBaseline mean age and diabetes duration were 27 and 19 years, respectively. We observed an early asymptote and then fall in diastolic blood pressure in their late 30s and early 40s in this group of type 1 diabetes individuals, followed by an early rise of pulse pressure. Adjusted hazard ratios (HR) (95% con) for CAD associated with 1 SD pressure increase were 1.35 (1.17, 1.56) for systolic pressure; 1.30 (1.12, 1.51) for diastolic pressure; 1.20 (1.03, 1.39) for pulse pressure; and 1.35 (1.17, 1.56) for mean arterial pressure. Pulse pressure emerged as a strong predictor of CAD at age ≥ 35 years (HR: 1.49 [1.15, 1.94]) and for HbA1c ≥ 9% (HR: 1.32 [1.01, 1.72]).CONCLUSIONSIndividuals with type 1 diabetes may manifest early vascular aging by an early decline in diastolic blood pressure and rise in pulse pressure, the latter parameter becoming a comparable to systolic blood pressure in predictor incident CAD in those aged over 35 years and those with poor glycemic control.

1931-P: Skeletal Muscle (SM) Insulin Resistance (IR) in Coronary Artery Disease (CAD) in Type 1 Diabetes (T1D)

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1931-P
Author(s):  
KATHERINE V. WILLIAMS ◽  
CHRISTINA M. SHAY ◽  
JULIE PRICE ◽  
TREVOR J. ORCHARD ◽  
DAVID KELLEY
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Artery Disease

scholarly journals The role of coronary artery calcification testing in incident coronary artery disease risk prediction in type 1 diabetes

Diabetologia ◽  
2018 ◽  
Vol 62 (2) ◽  
pp. 259-268 ◽  
Author(s):  
Jingchuan Guo ◽  
Sebhat A. Erqou ◽  
Rachel G. Miller ◽  
Daniel Edmundowicz ◽  
Trevor J. Orchard ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Risk Prediction ◽  
Coronary Artery Calcification ◽  
Disease Risk ◽  
Coronary Artery Disease Risk ◽  
Artery Disease

The Association Between a Family History of Type 2 Diabetes and Coronary Artery Disease in a Type 1 Diabetes Population

Diabetes Care ◽  
1998 ◽  
Vol 21 (4) ◽  
pp. 610-614 ◽  
Author(s):  
J. R. Erbey ◽  
L. H. Kuller ◽  
D. J. Becker ◽  
T. J. Orchard
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Family History ◽  
History Of ◽  
Artery Disease

scholarly journals Coronary calcium in adults with type 1 diabetes: a stronger correlate of clinical coronary artery disease in men than in women

Diabetes ◽  
2000 ◽  
Vol 49 (9) ◽  
pp. 1571-1578 ◽  
Author(s):  
J. C. Olson ◽  
D. Edmundowicz ◽  
D. J. Becker ◽  
L. H. Kuller ◽  
T. J. Orchard
Keyword(s):  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Coronary Calcium ◽  
Artery Disease
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