2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2126-P
Author(s):  
ANDREW T. TEMPLIN ◽  
MAHNAZ MELLATI ◽  
DANIEL ZEMAN-MEIER ◽  
MEGHAN F. HOGAN ◽  
NATHALIE ESSER ◽  
...  
Keyword(s):  
Beta Cell ◽  
Islet Amyloid Polypeptide ◽  
Amyloid Deposition ◽  
Human Islet ◽  
Cell Secretion ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide ◽  
Beta Cell Secretion

Differences in amyloid deposition in islets of transgenic mice expressing human islet amyloid polypeptide versus human islets implanted into nude mice

Metabolism ◽  
1999 ◽  
Vol 48 (4) ◽  
pp. 448-454 ◽  
Author(s):  
Gunilla Westermark ◽  
Per Westermark ◽  
Decio L. Eizirik ◽  
Claes Hellerström ◽  
Niles Fox ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Nude Mice ◽  
Islet Amyloid Polypeptide ◽  
Human Islets ◽  
Amyloid Deposition ◽  
Human Islet ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

scholarly journals Beta-cell selective KATP-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity

2010 ◽  
Vol 165 (2-3) ◽  
pp. 158-162 ◽  
Author(s):  
Robert A. Ritzel ◽  
Sajith Jayasinghe ◽  
John B. Hansen ◽  
Jeppe Sturis ◽  
Ralf Langen ◽  
...  
Keyword(s):  
Beta Cell ◽  
Beta Cells ◽  
Katp Channel ◽  
Islet Amyloid Polypeptide ◽  
Human Islets ◽  
Human Islet ◽  
Islet Amyloid ◽  
Channel Activation ◽  
Human Islet Amyloid Polypeptide

scholarly journals The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice

Diabetologia ◽  
2003 ◽  
Vol 46 (1) ◽  
pp. 71-79 ◽  
Author(s):  
J. Vidal ◽  
C. Bruce Verchere ◽  
S. Andrikopoulos ◽  
F. Wang ◽  
R. Hull ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Apolipoprotein E ◽  
Islet Amyloid Polypeptide ◽  
Amyloid Deposition ◽  
Human Islet ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

Two novel immortal pancreatic beta-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid

Diabetes ◽  
1999 ◽  
Vol 48 (10) ◽  
pp. 1962-1970 ◽  
Author(s):  
S. Andrikopoulos ◽  
C. B. Verchere ◽  
J. C. Teague ◽  
W. M. Howell ◽  
W. Y. Fujimoto ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Lines ◽  
Pancreatic Beta Cell ◽  
Islet Amyloid Polypeptide ◽  
Human Islet ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

scholarly journals Effects of beta cell granule components on human islet amyloid polypeptide fibril formation

FEBS Letters ◽  
1996 ◽  
Vol 379 (3) ◽  
pp. 203-206 ◽  
Author(s):  
Per Westermark ◽  
Zhan-Chun Li ◽  
Gunilla T. Westermark ◽  
Arnold Leckström ◽  
Donald F. Steiner
Keyword(s):  
Beta Cell ◽  
Islet Amyloid Polypeptide ◽  
Fibril Formation ◽  
Human Islet ◽  
Cell Granule ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide
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