1463-P: Relationship between Hepatic and Adipose Tissue Insulin Resistance with Liver Fibrosis in Patients with Type 2 Diabetes Mellitus (T2DM) and Nonalcoholic Fatty Liver Disease (NAFLD)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1463-P
Author(s):  
SRILAXMI KALAVALAPALLI ◽  
ROMINA LOMONACO ◽  
EDDISON GODINEZ ◽  
NADA FANOUS ◽  
LAZARO J. TEJERA ◽  
...  
2020 ◽  
Vol 2020 ◽  
pp. 1-16 ◽  
Author(s):  
Daniela Maria Tanase ◽  
Evelina Maria Gosav ◽  
Claudia Florida Costea ◽  
Manuela Ciocoiu ◽  
Cristina Mihaela Lacatusu ◽  
...  

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1461-P
Author(s):  
ROMINA LOMONACO ◽  
NADA FANOUS ◽  
SRILAXMI KALAVALAPALLI ◽  
LAZARO J. TEJERA ◽  
ALLISON MCCAULEY ◽  
...  

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