449-P: Impact of Body Mass Index (BMI) and Waist Circumference (WC) on Coronary Artery Disease (CAD) in Japanese with and without Diabetes Mellitus (DM)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 449-P
Author(s):  
TAKESHI KOMATSU ◽  
KAZUYA FUJIHARA ◽  
MAYUKO H. YAMADA ◽  
TAKAAKI SATO ◽  
MASARU KITAZAWA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Coronary Artery ◽  
Waist Circumference ◽  
Body Mass ◽  
Artery Disease

scholarly journals 244 Prevalence and clinical predictors of inappropriate direct oral anticoagulant dosage in octagenarians with atrial fibrillation

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Andreina Carbone ◽  
Francesco Santelli ◽  
Roberta Bottino ◽  
Emilio Attena ◽  
Carmine Mazzone ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Atrial Fibrillation ◽  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Coronary Artery ◽  
Body Mass ◽  
Male Gender ◽  
Research Database ◽  
Clinical Predictors ◽  
Artery Disease

Abstract Aims Older age is associated with inappropriate dose prescription of direct oral anticoagulants. The aim of our study was to describe the prevalence and the clinical predictors of inappropriate DOACs dosage among octogenarians in real-world setting. Methods Data for this study were sourced from the multicentre prospectively maintained Atrial Fibrillation (AF) Research Database (NCT03760874). AF patients aged ≥80 who received DOACs treatment 253 patients were selected. Participants were categorized as appropriate dosage, overdosage, or underdosage. Underdosage and overdosage were respectively defined as administration of a lower or higher DOAC dose than recommended in the EHRA consensus. Results A total of 178 patients (71%) received appropriate DOACs dose and 75 patients (29%) inappropriate DOACs dose; among them 19 patients (25.6%) were overdosed and 56 (74.4%) were underdosed. Subgroup analysis demonstrated that underdosage was independently associated with male gender [OR = 3.15 (95% IC 1.45–6.83); P < 0.01], coronary artery disease [OR = 3.6 (95% IC 1.41–9.1); P< 0.01] and body mass index [OR = 1.27 (1.14–1.41); P < 0.01]. Overdosage was independently associated with diabetes mellitus [OR = 18 (3.36–96); P < 0.01], with age [OR = 0.76 (95% IC; 0.61–0.96); P < 0.05], BMI [OR = 0.77 (0.11; 0.62–0.97); P < 0.05] and with previous bleedings [OR = 6.4 (0.7; 1.43–28) P < 0.05]. There wasn’t significant difference in thromboembolic, major bleeding events and mortality among different subgroups. Underdosage group showed a significatively lower survival compared with appropriate dose group (P < 0.001). Conclusion In our analysis, nearly one-third of octogenarians with AF received an inappropriate dose of DOAC. Several clinical factors increased the risk of DOACs’ overdosage (diabetes mellitus Type II) or underdosage (male gender, coronary artery disease and higher body mass index). Octogenarians with inappropriate DOACs underdosage showed less survival.

Lichen sclerosus in men is associated with elevated body mass index, diabetes mellitus, coronary artery disease and smoking

2013 ◽  
Vol 32 (1) ◽  
pp. 105-108 ◽  
Author(s):  
Matthias D. Hofer ◽  
Joshua J. Meeks ◽  
Nitin Mehdiratta ◽  
Michael A. Granieri ◽  
John Cashy ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Coronary Artery ◽  
Body Mass ◽  
Lichen Sclerosus ◽  
Elevated Body Mass Index ◽  
Artery Disease

scholarly journals Prevalence and clinical predictors of inappropriate direct oral anticoagulant dosage in octagenarians with atrial fibrillation

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
A Carbone ◽  
F Santelli ◽  
R Bottino ◽  
E Attena ◽  
C Mazzone ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Atrial Fibrillation ◽  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Coronary Artery ◽  
Body Mass ◽  
Male Gender ◽  
Research Database ◽  
Clinical Predictors ◽  
Artery Disease

Abstract Aims Older age was associated to inappropriate dose prescription of direct oral anticoagulants. The aim of our study was to describe the prevalence and the clinical predictors of inappropriate DOACs dosage among octogenarians in real-world setting. Methods and results Data for this study were sourced from the multicenter prospectively maintained Atrial Fibrillation (AF) Research Database (NCT03760874). AF patients aged ≥ 80 who received DOACs treatment 253 patients were selected. Participants were categorized as appropriate dosage, overdosage, or underdosage. Underdosage and overdosage were respectively defined as administration of a lower or higher DOAC dose than recommended in the EHRA consensus. A total of 178 patients (71%) received appropriate DOACs dose and 75 patients (29%) inappropriate DOACs dose; among them 19 patients (25.6%) were overdosed and 56 (74.4%) were underdosed. Subgroup analysis demonstrated that underdosage was independently associated with male gender [OR=3,15 (95% IC 1.45–6.83); p<0,01], coronary artery disease [OR= 3,6 (95% IC 1.41–9.1); p<0,01] and body mass index [OR=1,27 (1.14–1.41); p<0,01]. Overdosage was independently associated with diabetes mellitus [OR= 18 (3.36–96); p<0,01]. There wasn't significant difference in thromboembolic, major bleeding events and mortality among different subgroups. Underdosage group showed a significatively lower survival compared with appropriate dose group (p<0,001). Conclusion In our analysis, nearly one-third of octogenarians with AF received an inappropriate dose of DOAC. Several clinical factors increased the risk of DOACs' overdosage (diabetes mellitus type II) or underdosage (male gender, coronary artery disease and higher body mass index). Octogenarians with inappropriate DOACs underdosage resulted in less survival. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Study of conicity index, body mass index and waist circumference as predictors of coronary artery disease

2017 ◽  
Vol 36 (5) ◽  
pp. 357-364
Author(s):  
Paula Caitano Fontela ◽  
Eliane Roseli Winkelmann ◽  
Paulo Ricardo Nazario Viecili
Keyword(s):  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Coronary Artery ◽  
Waist Circumference ◽  
Body Mass ◽  
Artery Disease ◽  
Conicity Index

Comparison of Body Mass Index and Waist/Height Ratio in Predicting Definite Coronary Artery Disease

2008 ◽  
Vol 53 (3-4) ◽  
pp. 162-166 ◽  
Author(s):  
M. Siavash ◽  
M. Sadeghi ◽  
F. Salarifar ◽  
M. Amini ◽  
F. Shojaee-Moradie
Keyword(s):  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Coronary Artery ◽  
Body Mass ◽  
Height Ratio ◽  
Artery Disease ◽  
Definite Coronary Artery Disease ◽  
Waist Height Ratio
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