168-OR: Five-Year Follow-up after Islet Transplantation in Nonuremic Patients with Type 1 Diabetes Mellitus and Hypoglycemia Unawareness: Favorable Long-Term Outcomes of Multicenter Trial at University of Chicago

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 168-OR
Author(s):  
PIOTR J. BACHUL ◽  
GABRIELA S. GENERETTE ◽  
PETER BOREK ◽  
JORDAN S. PYDA ◽  
ROI ANTEBY ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Multicenter Trial ◽  
Long Term Outcomes ◽  
Hypoglycemia Unawareness

Apolipoprotein B as a long-term predictor of mortality in type 1 diabetes mellitus: a 15-year follow up

2006 ◽  
Vol 260 (3) ◽  
pp. 272-280 ◽  
Author(s):  
C. STETTLER ◽  
Y. SUTER ◽  
S. ALLEMANN ◽  
M. ZWAHLEN ◽  
E. R. CHRIST ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Apolipoprotein B

Autoimmune thyroiditis in patients with type 1 diabetes mellitus: A long-term follow-up study

2019 ◽  
Vol 13 (1) ◽  
pp. 608-611
Author(s):  
Natalia Vallianou ◽  
Theodora Stratigou ◽  
Stavroula Koutroumpi ◽  
Barbara Vlassopoulou ◽  
Stylianos Tsagarakis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Autoimmune Thyroiditis ◽  
Follow Up Study ◽  
Long Term Follow Up

scholarly journals Longitudinal evaluation of endothelial function in children and adolescents with type 1 diabetes mellitus: A long-term follow-up study

2014 ◽  
Vol 56 (2) ◽  
pp. 188-195 ◽  
Author(s):  
Patrizia Bruzzi ◽  
Barbara Predieri ◽  
Viviana Dora Patianna ◽  
Annamaria Salvini ◽  
Rosario Rossi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Endothelial Function ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Follow Up Study ◽  
Long Term Follow Up

Single-Donor Islet Transplantation and Long-term Insulin Independence in Select Patients With Type 1 Diabetes Mellitus

2014 ◽  
Vol 98 (9) ◽  
pp. 1007-1012 ◽  
Author(s):  
David P. Al-Adra ◽  
Richdeep S. Gill ◽  
Sharleen Imes ◽  
Doug O’Gorman ◽  
Tatsuya Kin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Insulin Independence ◽  
Single Donor

Islet transplantation in type 1 diabetes mellitus: single center follow-up on 10 patients

2013 ◽  
Vol 8 (S 01) ◽  
Author(s):  
B Ludwig ◽  
A Reichel ◽  
A Steffen ◽  
S Ludwig ◽  
S Kersting ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Single Center

scholarly journals Carbon Monoxide in Pancreatic Islet Transplantation: A New Therapeutic Alternative to Patients With Severe Type 1 Diabetes Mellitus

2021 ◽  
Vol 12 ◽  
Author(s):  
George J. Dugbartey
Keyword(s):  
Diabetes Mellitus ◽  
Carbon Monoxide ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Molecular Mechanisms ◽  
Pancreatic Islet Transplantation

Pancreatic islet transplantation is a minimally invasive procedure to replace β-cells in a subset of patients with autoimmune type 1 diabetic mellitus, who are extremely sensitive to insulin and lack counter-regulatory measures, and thereby increasing their risk of neuroglycopenia and hypoglycemia unawareness. Thus, pancreatic islet transplantation restores normoglycemia and insulin independence, and prevents long-term surgical complications associated with whole-organ pancreas transplantation. Nonetheless, relative inefficiency of islet isolation and storage process as well as progressive loss of islet function after transplantation due to unvoidable islet inflammation and apoptosis, hinder a successful islet transplantation. Carbon monoxide (CO), a gas which was once feared for its toxicity and death at high concentrations, has recently emerged as a medical gas that seems to overcome the challenges in islet transplantation. This minireview discusses recent findings about CO in preclinical pancreatic islet transplantation and the underlying molecular mechanisms that ensure islet protection during isolation, islet culture, transplantation and post-transplant periods in type 1 diabetic transplant recipients. In addition, the review also discusses clinical translation of these promising experimental findings that serve to lay the foundation for CO in islet transplantation to replace the role of insulin therapy, and thus acting as a cure for type 1 diabetes mellitus and preventing long-term diabetic complications.

scholarly journals 207.2: Favorable 5-year Follow Up Outcomes After Islet Transplantation in Patients With Type 1 Diabetes Mellitus at University of Chicago

2021 ◽  
Vol 105 (12S1) ◽  
pp. S3-S3
Author(s):  
Piotr Bachul ◽  
Peter Borek ◽  
Roi Anteby ◽  
Gabriela S. Generette ◽  
Lindsay Basto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
University Of Chicago
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