scholarly journals Impact of Sex and Age at Onset of Diabetes on Mortality From Ischemic Heart Disease in Patients With Type 1 Diabetes

Diabetes Care ◽  
2013 ◽  
Vol 37 (1) ◽  
pp. 144-148 ◽  
Author(s):  
Valma Harjutsalo ◽  
Christine Maric-Bilkan ◽  
Carol Forsblom ◽  
Per-Henrik Groop
Keyword(s):  
Type 1 Diabetes ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Age At Onset ◽  
Ischemic Heart ◽  
Onset Of Diabetes

scholarly journals Modification of the Association Between Severe Hypoglycemia and Ischemic Heart Disease by Surrogates of Vascular Damage Severity in Type 1 Diabetes During ∼30 Years of Follow-up in the DCCT/EDIC Study

2021 ◽  
Author(s):  
Elke R. Fahrmann ◽  
Laura Adkins ◽  
Henry K. Driscoll
Keyword(s):  
Type 1 Diabetes ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Microvascular Complications ◽  
Vascular Complications ◽  
Severe Hypoglycemia ◽  
Vascular Damage ◽  
Diabetes Duration ◽  
Ischemic Heart

OBJECTIVE <p>Literature suggests that severe hypoglycemia (SH) may be linked to cardiovascular events only in older individuals with high cardiovascular risk score (CV-score). Whether a potential relationship between any-SH and cardiovascular disease exists and whether it is conditional on vascular damage severity in a young type 1 diabetes (T1D) cohort without apparent macro-vascular and no or mild-to-moderate micro-vascular complications at baseline is unknown.</p> <p>RESEARCH DESIGN AND METHODS</p> <p>We evaluated data of 1441 Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) volunteers (diabetes duration 1-15 years) followed for ~30 years. Time-dependent associations between any-SH, interactions of any-SH with surrogates of baseline micro-/macro- vascular damage severity (diabetes duration, Early Treatment Diabetic Retinopathy Study scale (ETDRS), Diabetes Complications Severity Index (DCSI), or CV-scores) and ischemic heart disease (IHD: death, silent/nonfatal myocardial infarct, revascularization, or confirmed angina) were analyzed.</p> <p>RESULTS</p> <p>Without interactions, in the minimal adjusted model controlling for confounding bias by age and HbA1c, SH was a significant IHD factor (p~0.003). SH remained a significant factor for IHD in fully adjusted models (p<0.05). In models with interactions, interactions between SH and surrogates of microvascular complications severity, but not between SH and CV-score, were significant. Hazard ratios for IHD based on SH increased 1.19-fold, 1.32-fold, and 2.21-fold for each additional year of diabetes duration, ETDRS-unit, and DCSI-unit, respectively. At time of IHD event, ~15% of 110 participants with SH had high CV-scores.</p> <p> </p> <p>CONCLUSION</p> <p>In a young T1D cohort with no baseline macrovascular complications, surrogates of baseline microvascular damage severity impact the effect of SH on IHD. Older age with high CV-score per se is not mandatory for an association of SH with IHD. However, the association is multifactorial.</p>

scholarly journals Plasma Copeptin, Kidney Outcomes, Ischemic Heart Disease, and All-Cause Mortality in People With Long-standing Type 1 Diabetes

Diabetes Care ◽  
2016 ◽  
Vol 39 (12) ◽  
pp. 2288-2295 ◽  
Author(s):  
Gilberto Velho ◽  
Ray El Boustany ◽  
Guillaume Lefèvre ◽  
Kamel Mohammedi ◽  
Frédéric Fumeron ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
All Cause Mortality

Risk factors for mortality and ischemic heart disease in patients with long-term type 1 diabetes

2010 ◽  
Vol 24 (4) ◽  
pp. 223-228 ◽  
Author(s):  
Jakob Grauslund ◽  
Trine M.M. Jørgensen ◽  
Mads Nybo ◽  
Anders Green ◽  
Lars M. Rasmussen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Term Type

scholarly journals Modification of the Association Between Severe Hypoglycemia and Ischemic Heart Disease by Surrogates of Vascular Damage Severity in Type 1 Diabetes During ∼30 Years of Follow-up in the DCCT/EDIC Study

2021 ◽  
Author(s):  
Elke R. Fahrmann ◽  
Laura Adkins ◽  
Henry K. Driscoll
Keyword(s):  
Type 1 Diabetes ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Microvascular Complications ◽  
Vascular Complications ◽  
Severe Hypoglycemia ◽  
Vascular Damage ◽  
Diabetes Duration ◽  
Ischemic Heart

OBJECTIVE <p>Literature suggests that severe hypoglycemia (SH) may be linked to cardiovascular events only in older individuals with high cardiovascular risk score (CV-score). Whether a potential relationship between any-SH and cardiovascular disease exists and whether it is conditional on vascular damage severity in a young type 1 diabetes (T1D) cohort without apparent macro-vascular and no or mild-to-moderate micro-vascular complications at baseline is unknown.</p> <p>RESEARCH DESIGN AND METHODS</p> <p>We evaluated data of 1441 Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) volunteers (diabetes duration 1-15 years) followed for ~30 years. Time-dependent associations between any-SH, interactions of any-SH with surrogates of baseline micro-/macro- vascular damage severity (diabetes duration, Early Treatment Diabetic Retinopathy Study scale (ETDRS), Diabetes Complications Severity Index (DCSI), or CV-scores) and ischemic heart disease (IHD: death, silent/nonfatal myocardial infarct, revascularization, or confirmed angina) were analyzed.</p> <p>RESULTS</p> <p>Without interactions, in the minimal adjusted model controlling for confounding bias by age and HbA1c, SH was a significant IHD factor (p~0.003). SH remained a significant factor for IHD in fully adjusted models (p<0.05). In models with interactions, interactions between SH and surrogates of microvascular complications severity, but not between SH and CV-score, were significant. Hazard ratios for IHD based on SH increased 1.19-fold, 1.32-fold, and 2.21-fold for each additional year of diabetes duration, ETDRS-unit, and DCSI-unit, respectively. At time of IHD event, ~15% of 110 participants with SH had high CV-scores.</p> <p> </p> <p>CONCLUSION</p> <p>In a young T1D cohort with no baseline macrovascular complications, surrogates of baseline microvascular damage severity impact the effect of SH on IHD. Older age with high CV-score per se is not mandatory for an association of SH with IHD. However, the association is multifactorial.</p>

Hip Strength in Adults With Type 1 Diabetes is Associated With Age at Onset of Diabetes

2012 ◽  
Vol 15 (1) ◽  
pp. 78-85 ◽  
Author(s):  
Raelene E. Maser ◽  
Paul Kolm ◽  
Christopher M. Modlesky ◽  
Thomas J. Beck ◽  
M. James Lenhard
Keyword(s):  
Type 1 Diabetes ◽  
Age At Onset ◽  
Hip Strength ◽  
Onset Of Diabetes

Ischemic heart disease down-regulates angiotensin type 1 receptor mRNA in human coronary arteries

2004 ◽  
Vol 503 (1-3) ◽  
pp. 147-153 ◽  
Author(s):  
Angelica Wackenfors ◽  
Malin Emilson ◽  
Richard Ingemansson ◽  
Lars Edvinsson ◽  
Malin Malmsjö
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Coronary Arteries ◽  
Ischemic Heart ◽  
Receptor Mrna ◽  
Angiotensin Type

scholarly journals Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Ivan Dimitrijevic ◽  
Marie-Louise Edvinsson ◽  
Qingwen Chen ◽  
Malin Malmsjö ◽  
Per-Ola Kimblad ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Type B ◽  
Angiotensin Type
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