Epinephrine enhancement of potassium-stimulated immunoreactive insulin secretion. Role of beta-adrenergic receptors

Diabetes ◽  
1978 ◽  
Vol 27 (5) ◽  
pp. 550-553 ◽  
Author(s):  
N. Hiatt ◽  
M. B. Davidson ◽  
L. W. Chapman ◽  
J. A. Sheinkopf
1986 ◽  
Vol 64 (2) ◽  
pp. 203-211 ◽  
Author(s):  
David W. Hudgel ◽  
Nancy A. Kressin ◽  
Ann M. Nielsen ◽  
Gerald E. Bisgard

1978 ◽  
Vol 234 (2) ◽  
pp. E106 ◽  
Author(s):  
F Okajima ◽  
M Ui

Insulin secretory responses via adrenergic mechanisms were studied in vivo with hyperthyroid rats prepared by daily injections with thyroxine and with rats rendered hypothyroid by the addition of methylthiouracil in the drinking water. Isoproterenol, a beta-adrenergic agent, caused hyperinsulinemia in hyperthyroid rats more markedly than in euthyroid rats, but failed to induce hyperinsulinemia in hypothyroid rats. The isoproterenol-induced hyperinsulinemia was abolished by a beta-adrenergic receptor blocker in hyperthyroid as well as in euthyroid rats. The glucose-induced hyperinsulinemia was enhanced in hyperthyroid, was not essentially affected in euthyroid, and was inhibited in hypothyroid rats, by an alpha- and beta-adrenergic agent such as epinephrine. It is concluded that the relative function of alpha- to beta-adrenergic receptors responsible for the pancreatic secretion of insulin is dependent on the thyroid state; beta-adrenergic actions are predominant over alpha-actions in hyperthyroidism and vice versa in hypothyroidism.


2017 ◽  
Vol 38 (1) ◽  
pp. 109-120 ◽  
Author(s):  
Regina Celia Spadari ◽  
Claudia Cavadas ◽  
Ana Elisa T. Saturi de Carvalho ◽  
Daniela Ortolani ◽  
Andre Luiz de Moura ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document