Diabetes decreases Na+-K+ pump concentration in skeletal muscles, heart ventricular muscle, and peripheral nerves of rat

A 9-y-old, zoo-housed, male red panda ( Ailurus fulgens) became progressively lethargic and inappetent over a 1-wk period. Physical examination was unremarkable. A complete blood count showed mild normocytic, normochromic, non-regenerative anemia with the presence of trypomastigote organisms, consistent with a Trypanosoma sp. The organism was confirmed later as Trypanosoma cruzi lineage TcI via PCR and genome sequencing. The panda was initially treated supportively; however, its clinical status within 24 h from presentation deteriorated, and euthanasia was elected. Autopsy showed severe systemic T. cruzi infection with the presence of amastigotes in the heart, brain, peripheral nerves, skeletal muscles, tongue, liver, and testes. We used genome sequencing and serology in identifying the agent.

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Metastatic Multicentric Neurofibrosarcoma of the Lumbosacral Plexus in a Cow

Veterinary Pathology ◽

10.1177/030098589603300319 ◽

1996 ◽

Vol 33 (3) ◽

pp. 362-365 ◽

Cited By ~ 4

Author(s):

E. A. Sartin ◽

G. A. Herrera ◽

L. P. Wilkins ◽

D. F. Wolfe

Keyword(s):

Sacroiliac Joint ◽

Peripheral Nerves ◽

Skeletal Muscles ◽

Lumbar Vertebrae ◽

Intervertebral Foramen ◽

Lumbosacral Plexus ◽

Metastatic Lesions ◽

Collagenous Matrix ◽

S 100 ◽

Fibroblastic Cells

A metastatic multicentric neurofibrosarcoma of the lumbosacral plexus in an adult cow is described. The left lumbosacral plexus was obliterated by a mass which extended through the intervertebral foramen into the spinal canal and between the dorsal arches of the fifth and sixth lumbar vertebrae. A closely associated (possibly contiguous) mass extended into and separated the left sacroiliac joint. Multiple similar masses involved peripheral nerves and skeletal muscles of the pelvis, pelvic limbs, and abdominal wall. Metastatic lesions were scattered throughout the lungs. The lumbosacral lesion and all other masses consisted of interwoven bundles of loosely cohesive, elongated cells separated by variable collagenous matrix. Many neoplastic cells were positive for S-100 protein. Ultrastructurally, fibroblastic cells were mixed with scattered cells possessing schwannian characteristics.

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Peripheral Nerves and Skeletal Muscles

Textbook of Pathology for Allied Health Sciences ◽

10.5005/jp/books/14184_28 ◽

2017 ◽

pp. 317-317

Author(s):

Ramadas Nayak

Keyword(s):

Peripheral Nerves ◽

Skeletal Muscles

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Peripheral Nerves and Skeletal Muscles

Textbook of Pathology for BPT Students ◽

10.5005/jp/books/12850_24 ◽

2016 ◽

pp. 451-451

Author(s):

Ramadas Nayak

Keyword(s):

Peripheral Nerves ◽

Skeletal Muscles

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Inherited neuromuscular diseases in the mouse: a review of the literature

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x1988000300011 ◽

1988 ◽

Vol 46 (3) ◽

pp. 298-307 ◽

Cited By ~ 2

Author(s):

Luiz Fernando Bleggi Torres

Keyword(s):

Peripheral Nerves ◽

Skeletal Muscles ◽

Animal Species ◽

Neuromuscular Disorders ◽

Scientific Information ◽

Neuromuscular Diseases ◽

Experimental Manipulation ◽

Laboratory Animals ◽

Motor End Plates ◽

Low Costs

There are several neuromuscular disorders affecting the human being. Most of these are poorly understood and lack an effective treatment. Due to the limitation of experimental manipulation in «anima nobili», inherited neuromuscular diseases in laboratory animals constitute a valuable source of scientific information. Amongst several animal species affected by neuromuscular disorders the house mouse is of particular interest because of its small size, short pregnancy and low costs of maintanence. In the present review 20 murine mutants with diseases affecting peripheral nerves, skeletal muscles and motor end-plates are tabulated. Genetic, clinical and pathological aspects are discussed aiming to provide information about these mutants which might be of great interest as animal models for human neuromuscular diseases.

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