scholarly journals Autoimmunity against pancreatic islets and other tissues before and after interferon-alpha therapy in patients with hepatitis C virus chronic infection

Diabetes Care ◽  
2000 ◽  
Vol 23 (8) ◽  
pp. 1177-1181 ◽  
Author(s):  
C. Betterle ◽  
P. Fabris ◽  
R. Zanchetta ◽  
B. Pedini ◽  
G. Tositti ◽  
...  
2001 ◽  
Vol 7 (4-5) ◽  
pp. 779-786
Author(s):  
M. T. Abdel Aziz ◽  
Y. Abdel Ghaffar ◽  
H., H. Fouad ◽  
D. M. Abdel Aziz ◽  
A. A. El Magd

The ratio of stearic to oleic acids, i. e. the fatty acid saturation index, in red blood cell membranes was assayed in 60 patients with chronic hepatitis C virus infection before and after interferon-alpha therapy. Results were compared with 20 healthy controls. Hepatitis C virus titre was also assayed before and after interferon-alpha therapy. Within 2-5 months following interferon-alpha therapy, a significant inverse correlation was observed between saturation index and hepatitis C virus load. We conclude that hepatitis C virus infection enhances the degree of desaturation of 18-carbon fatty acids and that interferon-alpha is involved in their metabolism by increasing the degree of saturation and subsequent decrease in membrane fluidity.


1994 ◽  
Vol 33 (10) ◽  
pp. 588-592
Author(s):  
Makoto OKETANI ◽  
Keiichi TANAKA ◽  
Yukihiko SHO ◽  
Eiki MAEDA ◽  
Hiroomi MIYAZAKI ◽  
...  

2002 ◽  
Vol 37 (5) ◽  
pp. 701-702 ◽  
Author(s):  
Gabriel Perlemuter ◽  
Bahram Bodaghi ◽  
Phuc Le Hoang ◽  
Chaza Izem ◽  
Catherine Buffet ◽  
...  

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