Abstract
Background: Treatment indexes using continuous glucose monitoring (CGM) have become standardized internationally, and the use of ambulatory glucose profile (AGP) is currently recommended. However, the relationship between AGP indexes and standardized CGM metrics has not been investigated. Using flash glucose monitoring (FGM), this retrospective study served to evaluate the association of the inter-quartile range (IQR) of AGP with standardized CGM metrics.Methods: The study subjects were 30 patients with type 2 diabetes mellitus (T2DM) and 23 non-diabetic patients (control group). We evaluated average IQR (AIQR) and standardized CGM metrics. The primary endpoint was the relationship between AIQR and Time in range (TIR) in a 24-hour period.Results: In the T2DM group, the AIQR was notably high and correlated negatively with TIR, and positively with Time above range, average glucose level, SD, CV, and MODD. For the T2DM group, the AIQR was notably lower in patients who achieved TIR>70%, compared to those who did not. The AIQR cutoff value, as determined by ROC analysis, was 28.3 mg/dL for those who achieved TIR>70%. No association was detected between the presence of hypoglycemia and AIQR.Conclusions: Our study is the first to provide the AIQR cutoff value for achieving the TIR target value. The range of blood glucose variability in AGP was associated with indexes of intra- and interday variations and hyperglycemia. Our results provide new perspectives in the yet-to-be established methods for evaluation of AGP in practical clinical settings.
Reduction of Blood Glucose Variability in Type 1 Diabetic Patients Treated By Pancreatic Islet Transplantation: Interest of continuous glucose monitoring
