scholarly journals Hypoglycemic and Hyperglycemic Crises Among U.S. Adults With Diabetes and End-stage Kidney Disease: Population-Based Study, 2013–2017

2021 ◽  
Author(s):  
Rodolfo J. Galindo ◽  
Mohammed K. Ali ◽  
Shealeigh A. Funni ◽  
Andrew B. Dodge ◽  
Shaheen S. Kurani ◽  
...  
Keyword(s):  
Kidney Disease ◽  
The United States ◽  
Population Based ◽  
Emergency Department Visits ◽  
End Stage Kidney Disease ◽  
Population Based Study ◽  
Hyperglycemic Hyperosmolar State ◽  
Patients With Diabetes ◽  
End Stage ◽  
Event Rates

<b>Objective</b>: We characterized annual trends of severe hypoglycemic and hyperglycemic crises (diabetic ketoacidosis/hyperglycemic hyperosmolar state) in patients with diabetes and end-stage kidney disease (DM/ESKD). <p> </p> <p><b>Design</b>: Nationwide, retrospective study of adults (≥18 years) with DM/ESKD, from the United States Renal Data System registry, 2013 to 2017. Primary outcome was annual rates of emergency department visits or hospitalizations for hypoglycemic and hyperglycemic crises, reported as number of events/1000 person-years. Adjusted event rates and risk factors were adjusted for patient age, sex, race/ethnicity, dialysis modality, comorbidities, treatment regimen and U.S. region.</p> <p> </p> <p><b>Results</b>: Among 521,789 adults with DM/ESKD (median age 65 years [IQR 57-73], 56.1% male, and 46% White), overall adjusted rates of hypoglycemic and hyperglycemic crises were 53.64 and 18.24 per 1000 person-years, respectively. For both hypoglycemia and hyperglycemia crises, the risks decreased with age and were lowest in older patients (≥75 vs 18-44 years: IRR 0.35 [95% CI 0.33-0.37] and 0.03 [0.02-0.03], women (IRR 1.09 [1.06-1.12] and 1.44 [1.35-1.54]), and with smoking (IRR 1.36 [1.28-1.43] and 1.71 [1.53-1.91]), substance abuse (IRR 1.27 [1.15-1.42] and 1.53 [1.23-1.9]), retinopathy (IRR 1.10 [1.06-1.15] and 1.36 [1.26-1.47]), and insulin therapy (vs. no therapy; IRR 0.60 [0.59-0.63] and 0.44 [0.39-0.48]), respectively. For hypoglycemia, specifically, additional risk was conferred by Black race (IRR 1.11 [1.08-1.15]) and amputation history (IRR 1.20 [1.13-1.27]).</p> <p> </p> <p><b>Conclusions</b>: In this nationwide study of patients with DM/ESKD, hypoglycemic crises were three-fold more common than hyperglycemic crises, greatly exceeding national reports in non-dialysis patients with chronic kidney disease. Young, Black, and female patients were disproportionately affected. </p>

scholarly journals Hypoglycemic and Hyperglycemic Crises Among U.S. Adults With Diabetes and End-stage Kidney Disease: Population-Based Study, 2013–2017

2021 ◽  
Author(s):  
Rodolfo J. Galindo ◽  
Mohammed K. Ali ◽  
Shealeigh A. Funni ◽  
Andrew B. Dodge ◽  
Shaheen S. Kurani ◽  
...  
Keyword(s):  
Kidney Disease ◽  
The United States ◽  
Population Based ◽  
Emergency Department Visits ◽  
End Stage Kidney Disease ◽  
Population Based Study ◽  
Hyperglycemic Hyperosmolar State ◽  
Patients With Diabetes ◽  
End Stage ◽  
Event Rates

<b>Objective</b>: We characterized annual trends of severe hypoglycemic and hyperglycemic crises (diabetic ketoacidosis/hyperglycemic hyperosmolar state) in patients with diabetes and end-stage kidney disease (DM/ESKD). <p> </p> <p><b>Design</b>: Nationwide, retrospective study of adults (≥18 years) with DM/ESKD, from the United States Renal Data System registry, 2013 to 2017. Primary outcome was annual rates of emergency department visits or hospitalizations for hypoglycemic and hyperglycemic crises, reported as number of events/1000 person-years. Adjusted event rates and risk factors were adjusted for patient age, sex, race/ethnicity, dialysis modality, comorbidities, treatment regimen and U.S. region.</p> <p> </p> <p><b>Results</b>: Among 521,789 adults with DM/ESKD (median age 65 years [IQR 57-73], 56.1% male, and 46% White), overall adjusted rates of hypoglycemic and hyperglycemic crises were 53.64 and 18.24 per 1000 person-years, respectively. For both hypoglycemia and hyperglycemia crises, the risks decreased with age and were lowest in older patients (≥75 vs 18-44 years: IRR 0.35 [95% CI 0.33-0.37] and 0.03 [0.02-0.03], women (IRR 1.09 [1.06-1.12] and 1.44 [1.35-1.54]), and with smoking (IRR 1.36 [1.28-1.43] and 1.71 [1.53-1.91]), substance abuse (IRR 1.27 [1.15-1.42] and 1.53 [1.23-1.9]), retinopathy (IRR 1.10 [1.06-1.15] and 1.36 [1.26-1.47]), and insulin therapy (vs. no therapy; IRR 0.60 [0.59-0.63] and 0.44 [0.39-0.48]), respectively. For hypoglycemia, specifically, additional risk was conferred by Black race (IRR 1.11 [1.08-1.15]) and amputation history (IRR 1.20 [1.13-1.27]).</p> <p> </p> <p><b>Conclusions</b>: In this nationwide study of patients with DM/ESKD, hypoglycemic crises were three-fold more common than hyperglycemic crises, greatly exceeding national reports in non-dialysis patients with chronic kidney disease. Young, Black, and female patients were disproportionately affected. </p>

scholarly journals The incidence and survival after in-hospital cardiopulmonary cerebral resuscitation in end-stage kidney disease patients: A nationwide population-based study

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0238029
Author(s):  
Chia-Hung Yang ◽  
Jia-Jin Chen ◽  
Jih-Kai Yeh ◽  
George Kuo ◽  
Cheng-Chia Lee ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Population Based ◽  
End Stage Kidney Disease ◽  
Population Based Study ◽  
End Stage

scholarly journals Hypoglycemic and Hyperglycemic Crises Among U.S. Adults With Diabetes and End-stage Kidney Disease: Population-Based Study, 2013–2017

Diabetes Care ◽  
2021 ◽  
pp. dc211579
Author(s):  
Rodolfo J. Galindo ◽  
Mohammed K. Ali ◽  
Shealeigh A. Funni ◽  
Andrew B. Dodge ◽  
Shaheen S. Kurani ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Population Based ◽  
End Stage Kidney Disease ◽  
Population Based Study ◽  
End Stage

scholarly journals End-Stage Kidney Disease From Scleroderma in the United States, 1996 to 2012

2018 ◽  
Vol 3 (1) ◽  
pp. 148-154 ◽  
Author(s):  
Donal J. Sexton ◽  
Scott Reule ◽  
Robert N. Foley
Keyword(s):  
United States ◽  
Kidney Disease ◽  
The United States ◽  
End Stage Kidney Disease ◽  
End Stage

scholarly journals Outcomes Associated With Apixaban Use in Patients With End-Stage Kidney Disease and Atrial Fibrillation in the United States

Circulation ◽  
2018 ◽  
Vol 138 (15) ◽  
pp. 1519-1529 ◽  
Author(s):  
Konstantinos C. Siontis ◽  
Xiaosong Zhang ◽  
Ashley Eckard ◽  
Nicole Bhave ◽  
Douglas E. Schaubel ◽  
...  
Keyword(s):  
United States ◽  
Atrial Fibrillation ◽  
Kidney Disease ◽  
The United States ◽  
End Stage Kidney Disease ◽  
End Stage

scholarly journals Contraceptive Use Among Women With End-Stage Kidney Disease on Dialysis in the United States

2020 ◽  
Vol 2 (6) ◽  
pp. 707-715.e1
Author(s):  
Silvi Shah ◽  
Annette L. Christianson ◽  
Charuhas V. Thakar ◽  
Samantha Kramer ◽  
Karthikeyan Meganathan ◽  
...  
Keyword(s):  
United States ◽  
Kidney Disease ◽  
Contraceptive Use ◽  
The United States ◽  
End Stage Kidney Disease ◽  
End Stage

Trends in Place of Death for Individuals With Deaths Attributed to Advanced Chronic or End-Stage Kidney Disease in the United States

2021 ◽  
Vol 61 (1) ◽  
pp. 112-120.e1
Author(s):  
Sarah H. Cross ◽  
Joshua R. Lakin ◽  
Mallika Mendu ◽  
Ernest I. Mandel ◽  
Haider J. Warraich
Keyword(s):  
United States ◽  
Kidney Disease ◽  
The United States ◽  
Place Of Death ◽  
End Stage Kidney Disease ◽  
End Stage

scholarly journals Response by Siontis et al to Letter Regarding Article, “Outcomes Associated With Apixaban Use in Patients With End-Stage Kidney Disease and Atrial Fibrillation in the United States”

Circulation ◽  
2019 ◽  
Vol 139 (12) ◽  
pp. 1563-1564
Author(s):  
Konstantinos C. Siontis ◽  
Xiaosong Zhang ◽  
Douglas E. Schaubel ◽  
Xiaoxi Yao ◽  
Peter A. Noseworthy ◽  
...  
Keyword(s):  
United States ◽  
Atrial Fibrillation ◽  
Kidney Disease ◽  
The United States ◽  
End Stage Kidney Disease ◽  
End Stage
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