Histological Inflammatory Responses in the Placenta and Early Neonatal Brain Injury

2008 ◽  
Vol 11 (5) ◽  
pp. 350-354 ◽  
Author(s):  
Vincenzo Zanardo ◽  
Stefania Vedovato ◽  
Agnese Suppiej ◽  
Daniele Trevisanuto ◽  
Mauro Migliore ◽  
...  
Keyword(s):  
Brain Injury ◽  
Inflammatory Responses ◽  
Neonatal Brain ◽  
Neonatal Brain Injury

HISTOLOGICAL INFLAMMATORY RESPONSES IN THE PLACENTA AND EARLY NEONATAL BRAIN INJURY

2006 ◽  
Vol preprint (2008) ◽  
pp. 1
Author(s):  
Vincenzo Zanardo ◽  
Stefania Vedovato ◽  
Agnese Suppiej ◽  
Daniele Trevisanuto ◽  
Mauro Migliore ◽  
...  
Keyword(s):  
Brain Injury ◽  
Inflammatory Responses ◽  
Neonatal Brain ◽  
Neonatal Brain Injury

scholarly journals Hypoxic Preconditioning Suppresses Glial Activation and Neuroinflammation in Neonatal Brain Insults

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Chien-Yi Chen ◽  
Wei-Zen Sun ◽  
Kai-Hsiang Kang ◽  
Hung-Chieh Chou ◽  
Po-Nien Tsao ◽  
...  
Keyword(s):  
Brain Injury ◽  
Inflammatory Responses ◽  
Hypoxic Preconditioning ◽  
Glial Activation ◽  
Neonatal Brain ◽  
Mixed Glial Culture ◽  
Neonatal Brain Injury ◽  
Promising Therapeutic Approach ◽  
Hypoxia Ischemia

Perinatal insults and subsequent neuroinflammation are the major mechanisms of neonatal brain injury, but there have been only scarce reports on the associations between hypoxic preconditioning and glial activation. Here we use neonatal hypoxia-ischemia brain injury model in 7-day-old rats andin vitrohypoxia model with primary mixed glial culture and the BV-2 microglial cell line to assess the effects of hypoxia and hypoxic preconditioning on glial activation. Hypoxia-ischemia brain insult induced significant brain weight reduction, profound cell loss, and reactive gliosis in the damaged hemisphere. Hypoxic preconditioning significantly attenuated glial activation and resulted in robust neuroprotection. As early as 2 h after the hypoxia-ischemia insult, proinflammatory gene upregulation was suppressed in the hypoxic preconditioning group.In vitroexperiments showed that exposure to 0.5% oxygen for 4 h induced a glial inflammatory response. Exposure to brief hypoxia (0.5 h) 24 h before the hypoxic insult significantly ameliorated this response. In conclusion, hypoxic preconditioning confers strong neuroprotection, possibly through suppression of glial activation and subsequent inflammatory responses after hypoxia-ischemia insults in neonatal rats. This might therefore be a promising therapeutic approach for rescuing neonatal brain injury.

Hyperoxia and neonatal brain injury

2005 ◽  
Vol 36 (02) ◽  
Author(s):  
U Felderhoff-Mueser ◽  
AM Kaindl ◽  
C Bührer ◽  
H Ikonomidou
Keyword(s):  
Brain Injury ◽  
Neonatal Brain ◽  
Neonatal Brain Injury

Drug delivery platforms for neonatal brain injury

2021 ◽  
Author(s):  
Rukhmani Narayanamurthy ◽  
Jung-Lynn Jonathan Yang ◽  
Jerome Y. Yager ◽  
Larry D. Unsworth
Keyword(s):  
Drug Delivery ◽  
Brain Injury ◽  
Neonatal Brain ◽  
Neonatal Brain Injury

The common antitussive agent dextromethorphan protects against hyperoxia-induced cell death in established in vivo and in vitro models of neonatal brain injury

Neuroscience ◽  
2014 ◽  
Vol 274 ◽  
pp. 260-272 ◽  
Author(s):  
A. Posod ◽  
K. Pinzer ◽  
M. Urbanek ◽  
K. Wegleiter ◽  
M. Keller ◽  
...  
Keyword(s):  
Cell Death ◽  
Brain Injury ◽  
In Vitro Models ◽  
Neonatal Brain ◽  
Neonatal Brain Injury ◽  
The Common

scholarly journals Baby STEPS: A Giant Leap for Cell Therapy in Neonatal Brain Injury

2011 ◽  
Vol 70 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Cesar V Borlongan ◽  
Michael D Weiss
Keyword(s):  
Brain Injury ◽  
Cell Therapy ◽  
Neonatal Brain ◽  
Neonatal Brain Injury ◽  
Giant Leap

scholarly journals Stromal Cell-Derived Factor-1α Plays a Crucial Role Based on Neuroprotective Role in Neonatal Brain Injury in Rats

2015 ◽  
Vol 16 (8) ◽  
pp. 18018-18032 ◽  
Author(s):  
Miki Mori ◽  
Keiichi Matsubara ◽  
Yuko Matsubara ◽  
Yuka Uchikura ◽  
Hisashi Hashimoto ◽  
...  
Keyword(s):  
Brain Injury ◽  
Crucial Role ◽  
Stromal Cell ◽  
Neonatal Brain ◽  
Neonatal Brain Injury ◽  
Stromal Cell Derived Factor ◽  
Role Based

scholarly journals Acute Perinatal Sentinel Events, Neonatal Brain Injury Pattern, and Outcome of Infants Undergoing a Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy

2017 ◽  
Vol 180 ◽  
pp. 275-278.e2 ◽  
Author(s):  
Seetha Shankaran ◽  
Abbot R. Laptook ◽  
Scott A. McDonald ◽  
Susan R. Hintz ◽  
Patrick D. Barnes ◽  
...  
Keyword(s):  
Brain Injury ◽  
Injury Pattern ◽  
Hypoxic Ischemic Encephalopathy ◽  
Neonatal Brain ◽  
Neonatal Brain Injury ◽  
Sentinel Events ◽  
Ischemic Encephalopathy
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