Second Trimester Uterine Artery Doppler Velocimetry and Serum Lipids for Prediction of Pre-Eclampsia

Background: Reliable markers for prediction and prevention of pre-eclampsia to reduce its associated maternal and perinatal morbidity are lacking. Aim and objectives: To evaluate uterine artery doppler velocimetry and serum lipids in second trimester of pregnancy for prediction of gestational hypertension and pre-eclampsia. Methods: One hundred healthy and normotensive women were enrolled in 2nd trimester of pregnancy. Presence of notching in uterine artery doppler on USG and serum lipid levels were recorded. All women were followed till term/delivery to see development of pre-eclampsia / gestational hypertension later. Results: Absence of diastolic notch in 2nd trimester USG, serum triglycerides levels of <150 mg/dL and serum LDL levels of <100 mg/dL in 2nd trimester of pregnancy were found to have a good negative predictive value of 96.6%, 96.3%, 92.7% for later development of GH/PE. Conclusion: Absent diastolic notch, serum triglycerides <150mg/dL and LDL <100 mg/dL in 2nd trimester of pregnancy can be used to stratify women with low risk pregnancy.

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Uterine Artery Doppler Velocimetry During Mid-second Trimester to Predict Complications of Pregnancy Based on Unilateral or Bilateral Abnormalities

Yonsei Medical Journal ◽

10.3349/ymj.2005.46.5.652 ◽

2005 ◽

Vol 46 (5) ◽

pp. 652 ◽

Cited By ~ 7

Author(s):

Yong Won Park ◽

Jong Chul Lim ◽

Young Han Kim ◽

Han Sung Kwon

Keyword(s):

Uterine Artery ◽

Doppler Velocimetry ◽

Second Trimester ◽

Uterine Artery Doppler

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Role of second trimester uterine artery doppler for the prediction of preeclampsia in high risk pregnancy

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20190855 ◽

2019 ◽

Vol 8 (3) ◽

pp. 906

Author(s):

Madhuri Thakur ◽

Reeti Mehra

Keyword(s):

Risk Factors ◽

High Risk ◽

Uterine Artery ◽

High Risk Pregnancy ◽

Second Trimester ◽

Uterine Artery Doppler ◽

Risk Pregnancy ◽

Doppler Study ◽

Doppler Indices

Background: The uterine artery Doppler has potentials for screening for complications of impaired placentation. The purpose of study was to assess the role of uterine artery color Doppler waveform analysis in second trimester for the prediction of preeclampsia in a high-risk pregnancy between 18-24 weeks of gestation.Methods: 100 women with moderate or high-risk factors for developing preeclampsia reporting to Obstetrics and Gynaecology department of Government Medical College and Hospital, Sector 32, Chandigarh were enrolled for present study. Transabdominal uterine artery doppler measurements was done at 18-24weeks of gestation in these patients. Doppler . The Doppler indices generated automatically from the machine , the Pulsatility Index (PI), Resistance Index (RI) , presence or absence of diastolic notch and S/D Ratio were recorded, and average was calculated.Results: Out of 100 patients there were 46 primigravidas with no additional risk factors, 22 pateints with two or more risk factors and there were no patients who had three or more risk factors in present study population. Preeclampsia is seen more commonly in primigravida and primigravida is considered as moderate risk factor for preeclampsia. It was found that an elevated second trimester uterine artery RI was significantly associated with developing preeclampsia later in pregnancy. The sensitivity and specificity of uterine artery Doppler velocimetry were found to be 84% and 55% respectively. Receiver operator characteristics (ROC) curves were created to demonstrate the prognostic value of RI and PI of uterine artery doppler indices at 18-24 weeks of gestation for the development preeclampsia. In addition, there were statistically significant positive correlations between mean RI of uterine artery doppler study and patients who developed preeclampsia. With a sensitivity of 84.21% it could identify 31% of the cases of preeclampsia at a false positive rate of 44.4%.Conclusions: Uterine artery doppler study can be used as a predictor of moderate strength for preeclampsia.

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Doppler Velocimetry evaluation in high-risk pregnancy for prediction of Preeclampsia

Asian Journal of Medical Sciences ◽

10.3126/ajms.v12i10.38390 ◽

2021 ◽

Vol 12 (10) ◽

pp. 135-141

Author(s):

Rohini Singh ◽

Sudipa Mondal ◽

Manisha Bajaj ◽

Debasmita Mandal

Keyword(s):

High Risk ◽

Uterine Artery ◽

Umbilical Artery ◽

Doppler Velocimetry ◽

Third Trimester ◽

Uterine Artery Doppler ◽

Risk Pregnancy ◽

Patients At Risk ◽

Umbilical Artery Doppler ◽

Doppler Indices

Background: The uterine and umbilical artery Doppler scan is a valuable tool for evaluation of utero-placental blood flow in pregnancy. They help in detecting uteroplacental insufficiency thus predicting preeclampsia and other effects of faulty placentation which increase the risk of adverse effects on both mother and fetus. Aims and Objective: This study aimed to evaluate and compare the uterine artery and umbilical artery Doppler indices in second and third trimester for prediction of preeclampsia in high-risk pregnancies. Materials and Methods: In this prospective observational study done over a years’ time, 50 high-risk pregnant mothers were recruited and the Doppler scans were done at 21-25 weeks and 31-35 weeks. The necessary clinical observations were recorded throughout the antenatal period and the data analysis was done. Results: Majority (56%) were in 20-29 years range with mean age of 24±6.1 years. Out of the 50 women, 21 had abnormal uterine artery Doppler and 12 had umbilical artery abnormality along with uterine derangement. Preeclampsia developed in 3 of them. The hypertensive disorders of pregnancy were diagnosed in 13 women, preeclampsia in 3, eclampsia in 1and other HDPs in 9. The persistence of notch in uterine artery was observed in 7 women, of these 2 developed PIH. Only one patient had uterine artery PI>1.45 at 24 weeks who subsequently developed preeclampsia. Among 4 patients of preeclampsia and eclampsia, 3 had 2nd trimester uterine and 3rd trimester umbilical Doppler abnormalities and only 1 had normal doppler indices. In 2nd trimester the sensitivity, specificity and PPV are higher for uterine artery PI as compared to umbilical artery PI. Hence, uterine artery doppler seems to be a better screening tool for early prediction of PIH. The third trimester umbilical artery PI with higher specificity (96%) and PPV (50%) can diagnose preeclampsia better. One patient had absent diastolic flow and she developed preeclampsia and IUGR. The combined uterine and umbilical artery doppler is a better screening modality as it has a higher sensitivity (75%) and NPV (99.26%). Conclusion: The uterine and umbilical artery Doppler velocimetry are potential tools for uteroplacental surveillance of high-risk pregnancies which can identify patients at risk and help in taking timely action to prevent complications.

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