PULMONARY THROMBOEMBOLISM AND ROLE OF FACTOR V LEIDENIN ITS DEVELOPMENT-REVIEW OF LITERATURE

SummaryWe describe a patient with severe epistaxis, prolonged coagulation tests and decreased plasma factor V following exposure to bovine topical thrombin. Patient IgG, but not normal IgG, showed binding to immobilized thrombin (bovine > human) and fibrinogen, and to factor V by Western blotting; the binding to thrombin was inhibited by hirudin fragment 54-65. Electron microscopy of rotary shadowed preparations showed complexes with IgG molecules attached near the ends of trinodular fibrinogen molecules. Patient IgG inhibited procoagulant, anticoagulant and cell-stimulating functions of thrombin demonstrated by inhibition of fibrinogen clotting, protein C activation and platelet aggregation; thrombin hydrolysis of S-2238 was not inhibited. The results suggest that the antibody is targeted against anion-binding exosite and not catalytic site of thrombin. Antifibrinogen antibodies have not been reported in patients exposed to bovine thrombin. There is a pressing need to re-evaluate the role of bovine thrombin as a therapeutic agent.

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Studies on the Pathogenesis of the Generalized Shwartzman Reaction

Thrombosis and Haemostasis ◽

10.1055/s-0038-1655560 ◽

1964 ◽

Vol 12 (02) ◽

pp. 471-483 ◽

Cited By ~ 13

Author(s):

F Rodríguez-Erdmann

Keyword(s):

Clotting Factor ◽

Factor V ◽

Clotting System ◽

Platelet Factor ◽

Trigger Mechanism ◽

Haemorrhagic Diathesis ◽

Shwartzman Reaction ◽

Ca Ions

SummaryThe rôle of the clotting system in the pathogenesis of the generalized Shwartzman reaction (gSr) has been stressed in recent years. The clotting system is activated ubiquitously and as a result of it, fibrin is deposited intravascularly and a haemorrhagic diathesis develops. Evidence is presented herein, that endotoxin does not activate purified prothrombin, nor does endotoxin influence the convertion of prothrombin when it is activated in the presence of purified platelet-factor 3 (or caephalin) purified Ac-G (factor V) and Ca-ions.The trigger mechanism of the gSr also seems to be in the so-called prephase of clotting mechanism. Data are presented, which show that endotoxin activates the Hageman factor in vitro. The importance of this clotting factor and of platelet-factor 3 is discussed. Also the rôle played by the RES and cardiodynamic and vascular components are taken in consideration in the discussion.

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The role of mind-body interventions in pre-dialysis chronic kidney disease and dialysis patients – A systematic review of literature

Complementary Therapies in Medicine ◽

10.1016/j.ctim.2020.102652 ◽

2021 ◽

Vol 57 ◽

pp. 102652

Author(s):

Shu Wen Felicia Chu ◽

Cheng Teng Yeam ◽

Lian Leng Low ◽

Wei Yi Tay ◽

Wai Yin Marjorie Foo ◽

...

Keyword(s):

Systematic Review ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Review Of Literature ◽

Dialysis Patients

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The role of music therapy in the treatment of children with cancer: A systematic review of literature

Complementary Therapies in Clinical Practice ◽

10.1016/j.ctcp.2020.101289 ◽

2021 ◽

Vol 42 ◽

pp. 101289

Author(s):

Maria Facchini ◽

Chiara Ruini

Keyword(s):

Systematic Review ◽

Music Therapy ◽

Review Of Literature ◽

Children With Cancer

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The “Halalification” of tourism

Journal of Islamic Marketing ◽

10.1108/jima-01-2016-0001 ◽

2017 ◽

Vol 8 (4) ◽

pp. 558-577 ◽

Cited By ~ 22

Author(s):

Faiza Khan ◽

Michelle Callanan

Keyword(s):

Design Methodology ◽

Secondary Data ◽

Market Segment ◽

Analysis Method ◽

Review Of Literature ◽

Primary Research ◽

Content Type ◽

Starting Point ◽

Practical Implications

Purpose The purpose of this paper is to address the confusing use of terminology associated with tourism undertaken by Muslims and to identify key concerns associated with this type of tourism. Design/methodology/approach This is an exploratory study and adopts a critical review of literature following the evolutionary concept analysis method. Content analysis of popular UK media, UK-based tour operators’ websites and tourism strategies of destinations popular with Muslim tourists were conducted to examine the use of terminology. Findings There is no clear difference between the various terms (halal, Muslim friendly, Islamic, etc.) used. Overall, academia uses the term Islamic tourism, while the industry and media use various terms. Among destinations, however, there is no clear and consistent use of terminology. A key concern of Islamic tourism is the role of certification in assuring travellers and the lack of standardisation of halal certification. Research limitations/implications The paper is based on literature review and secondary data analysis. It lacks primary research. Practical implications This study highlights the need for consistent use of terminology across industry. Another implication is the issue surrounding halal certification of food and the importance of trust in the seller/service provide. Another trend that industry providers need to consider is the growth of the Muslim millennial traveller and the needs of this market segment. Originality/value The paper highlights the importance of studying the Muslim tourist market and provides a starting point for further research. It highlights several issues such as the need to develop a typology of Muslim tourists. Of particular interest is the concern whether halal values in danger of being commodified in the absence of a universal agreed criterion for halal certification.

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