Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report

2016 ◽  
Vol 1 (1) ◽  
pp. 64
Author(s):  
Nurul Azreen Hashim ◽  
Norley Shuib ◽  
Salina Mohamed ◽  
Ling Shiao Ling ◽  
Khariah Mat Nor
Keyword(s):  
Risk Factors ◽  
Carbon Monoxide ◽  
Case Report ◽  
Carbon Monoxide Poisoning ◽  
Neurological Manifestations ◽  
Mri Findings ◽  
Important Condition ◽  
Abnormal Signal ◽  
Delayed Neuropsychiatric Sequelae ◽  
Bizarre Behavior

Delayed neuropsychiatric sequelae is an important condition which commonly occur during recovery from acute carbon monoxide poisoning. Typical presentation would be apathy, disorientation, amnesia, hypokinesia, bizarre behavior, insomnia and neurological manifestations such as gait disturbance, hypertonia and tremor. We report here a case of a man presented with delayed neuropsychiatric sequelae one month after the carbon monoxide poisoning in his suicidal attempt. He presented with the typical presentation and diagnosis confirmed with the MRI findings. His MRI showed abnormal signal in subcortical hemisphere white matter of both temporo-fronto-parietal-occipital regions along the insula and both globus pallidus. He was treated with Olanzapine, Fluvoxamine, Chlorpromazine and Levodopa and his condition slowly improved. It is important for clinicians to recognize the symptoms and risk factors to develop delayed neuropsychiatric sequelae in patients who previously had carbon monoxide poisoning.

scholarly journals Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report

2019 ◽  
Vol 9 (11) ◽  
pp. 292 ◽  
Author(s):  
Tomosuke Nakano ◽  
Toshiki Hasegawa ◽  
Dai Suzuki ◽  
Eishi Motomura ◽  
Motohiro Okada
Keyword(s):  
Carbon Monoxide ◽  
Cognitive Impairment ◽  
Case Report ◽  
Brain Damage ◽  
Carbon Monoxide Poisoning ◽  
Gait Disturbance ◽  
Co Poisoning ◽  
Time And Space ◽  
Urine Incontinence ◽  
Delayed Neuropsychiatric Sequelae

Carbon monoxide (CO) poisoning causes severe brain damage, including delayed neuropsychiatric sequelae (DNS), which occur after a lucid interval following recovery from the insult of acute CO poisoning. We describe a 39-year-old male who developed DNS, including gait disturbance, trunk ataxia, and fecal/urine incontinence, after remission of acute CO poisoning. Furthermore, he showed confusion, with disorientation in terms of time and space. All symptoms, including cognitive impairment, were dramatically improved by amantadine monotherapy. The present case illustrates the possibility of amantadine treatment for cognitive impairment as well as Parkinsonism induced by CO poisoning.

Hyperbaric oxygen for late sequelae of carbon monoxide poisoning enhances neurological recovery: case report

2018 ◽  
Vol 45 (1) ◽  
pp. 83-87 ◽  
Author(s):  
Lon W. Keim ◽  
◽  
Sreekanth Koneru ◽  
Vesper Fe Marie Ramos ◽  
Najib Murr ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Case Report ◽  
Hyperbaric Oxygen ◽  
Carbon Monoxide Poisoning ◽  
Neurological Recovery ◽  
Late Sequelae

scholarly journals Predictive Role of QTc Prolongation in Carbon Monoxide Poisoning-Related Delayed Neuropsychiatric Sequelae

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Shu-Chen Liao ◽  
Yan-Chiao Mao ◽  
Yao-Min Hung ◽  
Ching-Hsing Lee ◽  
Chen-Chang Yang
Keyword(s):  
Carbon Monoxide ◽  
Roc Curve ◽  
Carbon Monoxide Poisoning ◽  
Chang Gung Memorial Hospital ◽  
Qtc Interval ◽  
Continuous Variables ◽  
Co Poisoning ◽  
Qtc Prolongation ◽  
Roc Curve Analysis ◽  
Delayed Neuropsychiatric Sequelae

Objective. Delayed neuropsychiatric sequelae (DNS) are serious complications of carbon monoxide (CO) poisoning that adversely affect poisoned patients’ quality of life as well as socioeconomic status. This study aimed to determine clinical predictors of DNS in patients with CO poisoning. Methods. This retrospective study included all CO-poisoned patients admitted to the emergency department (ED) of Linkou Chang Gung Memorial Hospital in Taiwan from 1 January 2009 to 31 December 2015. The medical records of all patients with CO poisoning were carefully reviewed, and relevant data were abstracted into a standardised form. Univariate and multivariate logistic regression models were used to identify predictors of DNS after CO poisoning. Receiver operating characteristic (ROC) curve analysis was used to determine the ideal cut-off value for continuous variables that predict the development of DNS. Results. A total of 760 patients with CO poisoning were identified during the study period. Among them, 466 were eligible for the analysis of predictors of DNS. In multivariate analysis, Glasgow Coma Scale <9 (odds ratio [OR], 2.74; 95% confidence interval [CI], 1.21–6.21), transient loss of consciousness (OR, 3.59; 95% CI, 1.31–9.79), longer duration from CO exposure to ED presentation (OR, 1.05; 95% CI, 1.03–1.08), and corrected QT (QTc) prolongation (OR, 2.61; 95% CI, 1.21–5.61) were found to be associated with a higher risk of DNS. The area under the ROC curve (AUC) for QTc interval measured within 6 h after exposure best predicted the development of DNS, with a result of 0.729 (95% CI 0.660–0.791). Moreover, the best cut-off value of the QTc interval was 471 ms, with a sensitivity of 53.3% and a specificity of 85.1%. Conclusions. We identified several potential predictors of DNS following CO poisoning. Among them, QTc prolongation found within 6 h after exposure is a novel predictor of DNS, which may be helpful in the future care of patients with CO poisoning.

scholarly journals Delayed Neurological Sequelae Following Carbon Monoxide Poisoning and Skin Graft: A Case Report

2020 ◽  
Vol 5 (4) ◽  
pp. 164-167
Author(s):  
Reza Bidaki ◽  
Azadeh Rahavi ◽  
Farzaneh Dehghani ◽  
Mohamad Ebrahim Ghanei ◽  
Najmeh Zaer-Alhosseini ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Case Report ◽  
Skin Graft ◽  
Carbon Monoxide Poisoning ◽  
Neurological Sequelae
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