Effects of equine recombinant interleukin-1 and interleukin-1 on proteoglycan metabolism and prostaglandin E2 synthesis in equine articular cartilage explants

2002 ◽  
Vol 63 (4) ◽  
pp. 551-558 ◽  
Author(s):  
Vivian A. Takafuji ◽  
C. Wayne McIlwraith ◽  
Rick D. Howard
Keyword(s):  
Articular Cartilage ◽  
Prostaglandin E2 ◽  
Interleukin 1 ◽  
Cartilage Explants

scholarly journals Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein

1984 ◽  
Vol 224 (2) ◽  
pp. 461-466 ◽  
Author(s):  
J Saklatvala ◽  
L M C Pilsworth ◽  
S J Sarsfield ◽  
J Gavrilovic ◽  
J K Heath
Keyword(s):  
Articular Cartilage ◽  
Prostaglandin E2 ◽  
Interleukin 1 ◽  
Thymocyte Proliferation

Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular cartilage. It augmented lectin-induced proliferation of mouse thymocytes, stimulated production of prostaglandin E2 and collagenase by fibroblasts and chondrocytes, and increased Ca2+ release from mouse calvarial explants, all at concentrations down to 50 pM. In view of these effects it was concluded that pig catabolin is a form of interleukin 1.

Effects of misoprostol and prostaglandin E2 on proteoglycan biosynthesis and loss in unloaded and loaded articular cartilage explants

1996 ◽  
Vol 52 (3) ◽  
pp. 157-173 ◽  
Author(s):  
Peter A. Torzilli ◽  
Armin M. Tehrany ◽  
Rita Grigiene ◽  
Eytan Young
Keyword(s):  
Articular Cartilage ◽  
Prostaglandin E2 ◽  
Cartilage Explants

scholarly journals Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability

2011 ◽  
Vol 13 (5) ◽  
pp. R146 ◽  
Author(s):  
Hiroto Mitsui ◽  
Tomoki Aoyama ◽  
Moritoshi Furu ◽  
Kinya Ito ◽  
Yonghui Jin ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Prostaglandin E2 ◽  
Receptor Type ◽  
Selective Agonist ◽  
Prostaglandin E2 Receptor
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