Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability

Hiroto Mitsui; Tomoki Aoyama; Moritoshi Furu; Kinya Ito; Yonghui Jin; Takayuki Maruyama; Toshiya Kanaji; Shinsei Fujimura; Hikaru Sugihara; Akio Nishiura; Takanobu Otsuka; Takashi Nakamura; Junya Toguchida

doi:10.1186/ar3460

Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability

Arthritis Research & Therapy ◽

10.1186/ar3460 ◽

2011 ◽

Vol 13 (5) ◽

pp. R146 ◽

Cited By ~ 10

Author(s):

Hiroto Mitsui ◽

Tomoki Aoyama ◽

Moritoshi Furu ◽

Kinya Ito ◽

Yonghui Jin ◽

...

Keyword(s):

Articular Cartilage ◽

Prostaglandin E2 ◽

Receptor Type ◽

Selective Agonist ◽

Prostaglandin E2 Receptor

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Expression and regulation of the rat prostaglandin E2 receptor type 4 (EP4) in pregnant cervical tissue

American Journal of Obstetrics and Gynecology ◽

10.1067/s0002-9378(03)00764-6 ◽

2003 ◽

Vol 189 (5) ◽

pp. 1501-1510 ◽

Cited By ~ 30

Author(s):

Edward K Chien ◽

Candace MacGregor

Keyword(s):

Prostaglandin E2 ◽

Receptor Type ◽

Cervical Tissue ◽

Prostaglandin E2 Receptor

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Activation of EP1 prostaglandin E2 receptor enhances arteriolar tone and blood pressure in mice with type 2 diabetes mellitus

The FASEB Journal ◽

10.1096/fasebj.22.2_supplement.61 ◽

2008 ◽

Vol 22 (S2) ◽

pp. 61-61

Author(s):

Attila Feher ◽

Ibolya Rutkai ◽

Timea Beleznai ◽

Istvan Edes ◽

Zsolt Bagi

Keyword(s):

Diabetes Mellitus ◽

Blood Pressure ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Prostaglandin E2 ◽

Prostaglandin E2 Receptor ◽

Arteriolar Tone

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Prostaglandin E2 receptor EP4-selective agonist (ONO-4819) increases bone formation by modulating mesenchymal cell differentiation

European Journal of Pharmacology ◽

10.1016/j.ejphar.2010.10.021 ◽

2011 ◽

Vol 650 (1) ◽

pp. 396-402 ◽

Cited By ~ 15

Author(s):

Tadashi Ninomiya ◽

Akihiro Hosoya ◽

Toru Hiraga ◽

Masanori Koide ◽

Kojiro Yamaguchi ◽

...

Keyword(s):

Cell Differentiation ◽

Bone Formation ◽

Prostaglandin E2 ◽

Mesenchymal Cell ◽

Selective Agonist ◽

Prostaglandin E2 Receptor

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Expression of the EP4 Prostaglandin E2 Receptor Subtype with Rat Dextran Sodium Sulphate Colitis: Colitis Suppression by a Selective Agonist, ONO-AE1-329

Scandinavian Journal of Immunology ◽

10.1046/j.1365-3083.2002.01096.x ◽

2002 ◽

Vol 56 (1) ◽

pp. 66-75 ◽

Cited By ~ 64

Author(s):

M. Nitta ◽

I. Hirata ◽

K. Toshina ◽

M. Murano ◽

K. Maemura ◽

...

Keyword(s):

Prostaglandin E2 ◽

Sodium Sulphate ◽

Receptor Subtype ◽

Dextran Sodium Sulphate ◽

Selective Agonist ◽

Prostaglandin E2 Receptor

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Prostaglandin E2 receptor (EP4) selective agonist (ONO-4819.CD) accelerates bone repair of femoral cortex after drill-hole injury associated with local upregulation of bone turnover in mature rats

Bone ◽

10.1016/j.bone.2004.01.002 ◽

2004 ◽

Vol 34 (6) ◽

pp. 940-948 ◽

Cited By ~ 84

Author(s):

Masahiro Tanaka ◽

Akinori Sakai ◽

Soshi Uchida ◽

Shinya Tanaka ◽

Masato Nagashima ◽

...

Keyword(s):

Bone Turnover ◽

Prostaglandin E2 ◽

Bone Repair ◽

Drill Hole ◽

Femoral Cortex ◽

Selective Agonist ◽

Prostaglandin E2 Receptor

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1030TiP An open-label multicenter phase Ib study of AN0025, a selective inhibitor of the prostaglandin E2 receptor-type-4 receptor, in combination with pembrolizumab in patients with advanced solid tumors

Annals of Oncology ◽

10.1016/j.annonc.2021.08.1414 ◽

2021 ◽

Vol 32 ◽

pp. S862-S863

Author(s):

W. Akerley ◽

M. Reilley ◽

A. Marabelle ◽

C. Baldini ◽

P.A. Cassier ◽

...

Keyword(s):

Prostaglandin E2 ◽

Solid Tumors ◽

Selective Inhibitor ◽

Receptor Type ◽

Advanced Solid Tumors ◽

Open Label ◽

Phase Ib ◽

Multicenter Phase ◽

Prostaglandin E2 Receptor

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2064-P: Pharmacological Modulation of Prostaglandin E2 Receptor Activity Enhances ß-Cell Mass and Maintains ß-Cell Identity in a Mouse Model of Type 2 Diabetes

Diabetes ◽

10.2337/db20-2064-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 2064-P

Author(s):

ASHLEY A. CHRISTENSEN ◽

SPENCER R. ANDREI ◽

JENNIFER C. DUNN ◽

VALERIE F. RICCIARDI ◽

WILLIAM A. PACE ◽

...

Keyword(s):

Type 2 Diabetes ◽

Mouse Model ◽

Prostaglandin E2 ◽

Cell Mass ◽

Receptor Activity ◽

Cell Identity ◽

Pharmacological Modulation ◽

Prostaglandin E2 Receptor

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A prostaglandin E2 receptor type 3 antagonist prevents ovulation in rhesus macaques

Fertility and Sterility ◽

10.1016/j.fertnstert.2015.07.121 ◽

2015 ◽

Vol 104 (3) ◽

pp. e39-e40

Author(s):

J.N. Bennett-Toomey ◽

M.J. Murphy ◽

N.G. Halow ◽

R.L. Stouffer ◽

J.D. Hennebold

Keyword(s):

Prostaglandin E2 ◽

Rhesus Macaques ◽

Receptor Type ◽

Prostaglandin E2 Receptor ◽

Type 3

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Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of Type 2 diabetes enhances β-cell proliferation and identity, and relieves oxidative damage

Molecular Metabolism ◽

10.1016/j.molmet.2021.101347 ◽

2021 ◽

pp. 101347

Author(s):

Karin J. Bosma ◽

Spencer R. Andrei ◽

Liora S. Katz ◽

Ashley A. Smith ◽

Jennifer C. Dunn ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cell Proliferation ◽

Oxidative Damage ◽

Prostaglandin E2 ◽

Β Cell ◽

Pharmacological Blockade ◽

Prostaglandin E2 Receptor

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196-OR: Pharmacological Modulation of Prostaglandin E2 Receptor Activity Enhances ß-Cell Mass in a Mouse Model of Type 2 Diabetes and Human Islets

Diabetes ◽

10.2337/db19-196-or ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 196-OR

Author(s):

SPENCER R. ANDREI ◽

JENNIFER C. DUNN ◽

ASHLEY A. CHRISTENSEN ◽

VALERIE F. RICCIARDI ◽

WILLIAM A. PACE ◽

...

Keyword(s):

Type 2 Diabetes ◽

Mouse Model ◽

Prostaglandin E2 ◽

Cell Mass ◽

Human Islets ◽

Receptor Activity ◽

Pharmacological Modulation ◽

Prostaglandin E2 Receptor

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