scholarly journals Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein

1984 ◽  
Vol 224 (2) ◽  
pp. 461-466 ◽  
Author(s):  
J Saklatvala ◽  
L M C Pilsworth ◽  
S J Sarsfield ◽  
J Gavrilovic ◽  
J K Heath
Keyword(s):  
Articular Cartilage ◽  
Prostaglandin E2 ◽  
Interleukin 1 ◽  
Thymocyte Proliferation

Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular cartilage. It augmented lectin-induced proliferation of mouse thymocytes, stimulated production of prostaglandin E2 and collagenase by fibroblasts and chondrocytes, and increased Ca2+ release from mouse calvarial explants, all at concentrations down to 50 pM. In view of these effects it was concluded that pig catabolin is a form of interleukin 1.

scholarly journals Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability

2011 ◽  
Vol 13 (5) ◽  
pp. R146 ◽  
Author(s):  
Hiroto Mitsui ◽  
Tomoki Aoyama ◽  
Moritoshi Furu ◽  
Kinya Ito ◽  
Yonghui Jin ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Prostaglandin E2 ◽  
Receptor Type ◽  
Selective Agonist ◽  
Prostaglandin E2 Receptor

Modulation of colony-stimulating activity by interleukin 1 mice: opposing effects of combined treatment with indomethacin of prostaglandin E2

1992 ◽  
Vol 14 (4) ◽  
pp. 655-659 ◽  
Author(s):  
Franca Campanile ◽  
Anna Bartocci ◽  
Lucia Binaglia ◽  
Maria C. Fioretti ◽  
E. Richard Stanley ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Interleukin 1 ◽  
Combined Treatment ◽  
Colony Stimulating Activity ◽  
Opposing Effects

scholarly journals Differential interleukin-1 elaboration by density-defined human monocyte subpopulations

Blood ◽  
1985 ◽  
Vol 66 (2) ◽  
pp. 298-301
Author(s):  
JA Elias ◽  
P Chien ◽  
KM Gustilo ◽  
AD Schreiber
Keyword(s):  
Human Blood ◽  
Interleukin 1 ◽  
Human Monocyte ◽  
Mononuclear Phagocytes ◽  
Blood Monocyte ◽  
Thymocyte Proliferation ◽  
Percoll Gradients ◽  
Human Blood Monocyte ◽  
Monocytes And Macrophages ◽  
Monocyte Subpopulations

Interleukin-1 (IL-1) is an important immunoregulatory peptide produced by monocytes and macrophages. Because mononuclear phagocytes are morphologically and functionally heterogeneous, we examined whether they differ in their ability to elaborate IL-1. We used discontinuous Percoll gradients to obtain five density-defined human blood monocyte subpopulations. Unfractionated monocytes and their subsets were compared for their ability to stimulate thymocyte proliferation. Supernatants obtained from the denser monocytes consistently contained more IL-1 activity than did supernatants from the less dense cells. This difference in IL-1 activity was the result of differences in IL-1 elaboration, not the selective production of an inhibitor of IL-1- induced thymocyte proliferation. These data demonstrate that density- defined human monocyte subpopulations differ in their capacity to elaborate IL-1.

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