RELATIONSHIP BETWEEN BODY CONSTITUTION (SOMATOTYPE) AND DELAYED-RESPONSE PERFORMANCE OF DOGS

1959 ◽  
Vol 5 ◽  
pp. 495
Author(s):  
ALBERTO DIMASCIO
Keyword(s):  
Delayed Response ◽  
Body Constitution ◽  
Response Performance

Analysis of changes in indirect delayed response performance in monkeys with prefrontal lesions.

1969 ◽  
Vol 68 (1, Pt.1) ◽  
pp. 147-154 ◽  
Author(s):  
Roger W. Buddington ◽  
Frederick A. King ◽  
Lamar Roberts
Keyword(s):  
Delayed Response ◽  
Response Performance

Facilitation of Working Memory in Humans by a D2 Dopamine Receptor Agonist

1992 ◽  
Vol 4 (1) ◽  
pp. 58-68 ◽  
Author(s):  
Monica Luciana ◽  
Richard A. Depue ◽  
Paul Arbisi ◽  
Arthur Leon
Keyword(s):  
Working Memory ◽  
Receptor Agonist ◽  
Spatial Working Memory ◽  
Receptor Activation ◽  
Facilitatory Effect ◽  
Delayed Response ◽  
General Role ◽  
Da Receptors ◽  
Nonspecific Effects ◽  
Response Performance

Recent studies on the neurobiology of cognition have focused on the ability of the prefrontal cortex (PFC) to support processes of working memory, i.e, mnemonic processes by which information relevant for a correct response is temporarily maintained to be reevaluated or updated on a trial-by-trial basis. Of most recent interest is the role played by dopamine (DA) in spatial working memory processes of the principal sulcal region of the PFC. Although D1 DA receptors appear to modulate these mnemonic processes in monkeys, several lines of research suggest that D2 DA receptors could also be relevant to cognitive functions. Therefore, we assessed the effects of a specific D2 receptor agonist (bromocriptine) and placebo on visuospatial delayed response performance in human subjects. During delay periods of 0 or 8 sec, subjects were required to remember the spatial location of rapidly presented visual cues displayed in peripheral vision within a 360° circumference. The extent to which D2 receptor activation by bromocriptine facilitated working memory in the 8–sec delay condition relative to placebo performance was assessed. As a means of providing validation of bromocriptine's D2 receptor effect, maximum inhibition of prolactin (PRL) secretion, which is inhibited specifically by activation of D2 receptor sites, was determined. Additionally, tasks having no working memory component were administered to rule out nonspecific effects of bromocriptine on sensory, arousal, attentional, and motor factors. Results demonstrated a significant facilitatory effect of bromocriptine on spatial delayed response performance (i.e., 8–sec delay performance). Results could not be explained by nonspecific effects of bromocriptine. Thus, findings of this study suggest that spatial working memory is facilitated by D2 receptor activation. The role that DA may play in human cognitive processes is discussed within the larger theoretical framework of DA's general role in the facilitation of goal-directed behavior. In the case of cognition, DA may facilitate processes that serve to guide motivated behavior through complex environments.

Short- and Long-Term Spatial Delayed Response Performance Across the Lifespan

2004 ◽  
Vol 26 (3) ◽  
pp. 661-678 ◽  
Author(s):  
Ariel Lyons-Warren ◽  
Rema Lillie ◽  
Tamara Hershey
Keyword(s):  
Delayed Response ◽  
Short And Long Term ◽  
Response Performance

The Beneficial Effects of Meprobamate on Delayed Response Performance in the Frontal Monkey

1965 ◽  
Vol 17 (2) ◽  
pp. 118-124 ◽  
Author(s):  
L. Weiskrantz ◽  
C. G. Gross ◽  
V. Baltzer
Keyword(s):  
Sensory Information ◽  
Discrimination Performance ◽  
Delayed Response ◽  
Beneficial Effects ◽  
Logical Flaw ◽  
Response Performance

Previous studies of antagonistic treatments on delayed response performance by frontal monkeys suffer from a logical flaw in that the treatments may also improve the performance of normal monkeys. In a previous study (Gross and Weiskrantz, 1961) we have shown that meprobamate is without effect on delayed response in normal monkeys, but it does severely depress their discrimination performance. In the current study meprobamate is shown to produce a significant improvement in delayed response in each of three frontal monkeys. Nembutal is also effective. Various interpretations of the results are discussed, the view being favoured that the frontal monkey suffers from an excessive and inappropriately ordered intake of sensory information.

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