Proton magnetic resonance spectroscopy in patients with solitary and sporadic temporal lobe epileptic seizures

AbstractProton magnetic resonance spectroscopy (1H MRS) is an optional diagnostic method for potential epilepsy surgery candidates. The aim of this study was to determine the credibility of 1H MRS examination in a group of patients suffering from solitary and sporadic epileptic seizures generated in temporal lobe. We recorded a 100% sensitivity of 1H MRS in a group of ten patients in terms of detection of a pathological process in the temporal lobe. 1H MRS also enabled determination of lateralization of the pathological process in three patients with bilateral epileptiform abnormalities on electroencephalography. Based on these results we suggest new perspectives on 1H MRS as a part of standard diagnostic algorithm for solitary and sporadic temporal lobe epileptic seizures, particularly in cases with normal electroencephalography and magnetic resonance imaging findings.

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The Effect of Risperidone on Metabolite Measures in the Frontal Lobe, Temporal Lobe, and Thalamus in Schizophrenic Patients. A Proton Magnetic Resonance Spectroscopy (1H MRS) Study

Pharmacopsychiatry ◽

10.1055/s-2005-873156 ◽

2005 ◽

Vol 38 (5) ◽

pp. 214-219 ◽

Cited By ~ 49

Author(s):

A. Szulc ◽

B. Galinska ◽

E. Tarasow ◽

W. Dzienis ◽

B. Kubas ◽

...

Keyword(s):

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Frontal Lobe ◽

Temporal Lobe ◽

Proton Magnetic Resonance ◽

Proton Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

1H Mrs ◽

Schizophrenic Patients

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Analysis of brain metabolism by proton magnetic resonance spectroscopy (1H-MRS) in attention-deficit/hyperactivity disorder suggests a generalized differential ontogenic pattern from controls

ADHD Attention Deficit and Hyperactivity Disorders ◽

10.1007/s12402-012-0088-0 ◽

2012 ◽

Vol 4 (4) ◽

pp. 205-212 ◽

Cited By ~ 14

Author(s):

Mauricio Arcos-Burgos ◽

Ana C. Londoño ◽

David A. Pineda ◽

Francisco Lopera ◽

Juan David Palacio ◽

...

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Proton Magnetic Resonance ◽

Proton Magnetic Resonance Spectroscopy ◽

Brain Metabolism ◽

Resonance Spectroscopy ◽

1H Mrs ◽

Hyperactivity Disorder ◽

Generalized Differential

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81 IN VIVO PROTON MAGNETIC RESONANCE SPECTROSCOPY (1H-MRS) IN CYSTIC LEUCOMALACIA OF INFANCY

Pediatric Research ◽

10.1203/00006450-199407000-00081 ◽

1994 ◽

Vol 36 (1) ◽

pp. 16A-16A

Author(s):

Floris Groenendaal ◽

Paula Eken ◽

Jeroen Van Der Grond ◽

Karin Rademaker ◽

Linda S De Vries

Keyword(s):

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Proton Magnetic Resonance ◽

Proton Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

1H Mrs

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P2-175 Role of proton magnetic resonance spectroscopy (1H-MRS) in predicting the conversion of mild cognitive impairment to dementia

Neurobiology of Aging ◽

10.1016/s0197-4580(04)80921-7 ◽

2004 ◽

Vol 25 ◽

pp. S276-S277

Author(s):

Antonio Metastasio ◽

Patrizia Rinaldi ◽

Filippo Feliziani ◽

Elena Mariani ◽

Roberto Tarducci ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Proton Magnetic Resonance ◽

Proton Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

1H Mrs

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Association between altered proton magnetic resonance spectroscopy (1H MRS) findings and clinical symptoms of schizophrenia.

Revista de Neuro-Psiquiatria ◽

10.20453/rnp.v74i1.1672 ◽

2013 ◽

Vol 74 (1) ◽

pp. 183-190

Author(s):

Senair Alberto Ambros ◽

Paulo Belmonte Abreu ◽

Eloísa Elena Ferreira ◽

Pdro Eugenio Ferreira ◽

Luciana Estacia Ambros

Keyword(s):

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Proton Magnetic Resonance ◽

Proton Magnetic Resonance Spectroscopy ◽

Clinical Symptoms ◽

Resonance Spectroscopy ◽

Thalamic Nuclei ◽

1H Mrs ◽

Disorganized Speech ◽

The Right

Objective: To assess the metabolic alterations of the thalamus in subjects with schizophrenia compared to healthysubjects and to investigate whether specific schizophrenic symptoms are associated with metabolic alterationsmeasured by 1H MRS. Methods: This is a case-control study including patients with schizophrenia diagnosed usingthe Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition, DMS-IV and the Operational CriteriaChecklist for Psychotic Illness (OPCRIT). Proton magnetic resonance spectroscopy (1H MRS) was used to assessmetabolite concentrations (N-acetylaspartate, choline, creatinine, myoionositol and lactacte) in the left and rightthalamus of 13 patients with schizophrenia and 13 healthy controls. Results: In this study, concentrations ofspecific metabolites in the thalamus, determined by 1H MRS, were similar for individuals with schizophrenia andcontrols. It was observed that cases with family history of schizophrenia and disorganized speech demonstrated areduction in the ratio of the metabolites NAA /Cho in the thalamic nuclei on the right side. However, those withorganized delusions, hallucinations and non-affective auditory hallucinations had an increase of metabolites on theright side compared to the left thalamus. Decreased thalamic metabolic activity in patients with positive symptomswas observed in contrast with those who had well-organized delusions and auditory non-affective hallucinations,core symptoms of schizophrenia. Conclusion: A lateralized thalamic involvement was verified, suggesting thatorganic and genetic factors compromise the right thalamus and that the disorganization associated with delusionsand hallucinations compromises the left thalamic nuclei. Further studies to investigate the correlation betweensymptoms and thalamic dysfunction are warranted. (Rev Neuropsiquiatr 2011;74:183-190)

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