scholarly journals Aliskiren: Direct Renin Inhibitor Baru pada Terapi Hipertensi

2020 ◽  
pp. 59
Author(s):  
Ni Putu Uma Sari Dewi ◽  
I Gusti Ayu Artini Ekajaya Amandari ◽  
Made Winda Krisnayanti ◽  
Made Ary Sarasmita
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Angiotensin Receptor Blocker ◽  
Enzyme Inhibitor ◽  
Renin Inhibitor ◽  
Converting Enzyme ◽  
Angiotensin Receptor ◽  
Angiotensin I ◽  
Converting Enzyme Inhibitor ◽  
Direct Renin Inhibitor

Hipertensi merupakan kondisi ketika tekanan darah meningkat secara kronis. Mengacu pada hasil Riset Kesehatan Dasar (Riskesdas), Bali memiliki proporsi hipertensi sebesar 19,9%. Beberapa studi epidemiologis menyebutkan bahwa risiko kerusakan berbagai organ vital secara langsung berkorelasi dengan peningkatan tekanan darah. Oleh karena itu, diperlukan keteraturan dalam mengontrol dan juga meminum obat antihipertensi. Obat antihipertensi yang umum digunakan saat ini adalah angiotensin converting enzyme inhibitor (ACEI) dan angiotensin receptor blocker (ARB). Akan tetapi, temuan sebelumnya menyatakan bahwa ACEI dan ARB belum sepenuhnya efektif dalam menurunkan tekanan darah. Untuk mengatasi kelemahan tersebut, ditemukan direct renin inhibitor baru yaitu aliskiren. Aliskiren dapat memblokade renin-angiotensin-aldosterone system (RAAS) pada level tertinggi, sehingga kemampuan aliskiren dalam menurunkan tekanan darah tidak dapat diragukan lagi. Aliskiren mampu menghambat konversi angiotensinogen menjadi angiotensin I, sehingga dapat menurunkan tekanan darah secara berkelanjutan.

scholarly journals The Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker on the Outcome of Hospitalization of Patients With Hypertension and COVID-19

2021 ◽  
Vol 34 (6) ◽  
pp. 665-666
Author(s):  
Xi-jing Zhuang ◽  
Wen-jun Wang ◽  
Xiao-hui Zhao ◽  
Wei Wei ◽  
Wei-wang Fan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Creatine Kinase ◽  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Angiotensin Receptor Blocker ◽  
Enzyme Inhibitor ◽  
Converting Enzyme ◽  
Angiotensin Receptor ◽  
Converting Enzyme Inhibitor ◽  
Group A

Abstract Background To study the effect of angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) on the outcome of hospitalization in patients with hypertension and novel coronavirus disease 2019 (COVID-19). Methods A retrospective analysis was performed in 202 COVID-19 patients who were hospitalized in Thunder-God Hospital, Wuhan from 12 February 2020 to 30 March 2020. According to whether taking ACEI or ARB, 67 (33.0%) patients with hypertension were divided into 3 groups: A, patients received ACEI or ARB after admission (n = 22); B, patients received ACEI or ARB before admission but interrupted after admission (n = 24); and C, patients were not treated with ACEI or ARB before or after admission (n = 21). Changes of therapeutic indicators in all groups of patients and their application relationship with ACEI/ARB were compared and analyzed. Results There were no significant differences in age, gender, blood pressure, underlying disease severity, or serum biochemical indicators (ALT, LDH, creatinine, and creatine kinase levels) at admission among 3 groups (all P > 0.05). During hospitalization, there were no significant differences in COVID-19-related treatment, oxygen use, hospital mortality, recovery and discharge rate, or days of throat swab nucleic acid turning negative among 3 groups (all P > 0.05). The proportion of calcium channel blocker in groups B and C was higher than group A (95.8% and 85.7% vs. 40.9%, P < 0.01), but there was no significant difference in blood pressure or compliance rates at discharge (P > 0.05). Group A, B, and C patients were hospitalized for 27.4 ± 6.4, 30.0 ± 8.8, and 30.1 ± 9.3 days, respectively (all P > 0.05). Compared with admission values, there were no significant differences in serum ALT, LDH, creatinine, or creatine kinase levels among all 3 groups during hospitalization (all P > 0.05). Conclusions ACEI or ARB has no significant effect on the outcome of hospitalization in patients with hypertension and COVID-19.

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