scholarly journals Endoscopic laser lithotripsy as an option of treatment tactics of complicated choledocholithiasis in the patient aged 96 years

2021 ◽  
Vol 180 (4) ◽  
pp. 86-90
Author(s):  
M. Yu. Kabanov ◽  
K. V. Sementsov ◽  
D. B. Degterev ◽  
D. K. Savchenkov ◽  
T. E. Koshelev ◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Female Patient ◽  
Postoperative Period ◽  
Laser Lithotripsy ◽  
Efficacy And Safety ◽  
High Efficacy ◽  
Strong Argument ◽  
Endoscopic Laser ◽  
Grade Ii ◽  
Endoscopic Operation

We present the case of treatment of choledocholithiasis complicated with obstructive jaundice and acute grade II cholangitis according to Tokyo criteria in the female patient aged 96 years with significant comorbidity. Peroral digital cholangioscopy and laser contact lithotripsy were made. No complications were observed in postoperative period, and the manifestations of cholangitis and obstructive jaundice regressed. In our opinion, high efficacy and safety of the used method are the strong argument for the use in patients with difficult choledocholithiasis who have significant comorbidities during the single-stage endoscopic operation.

Efficacy and safety of endoscopic laser lithotripsy for urinary stone treatment in children

2012 ◽  
Vol 40 (6) ◽  
pp. 751-755 ◽  
Author(s):  
Ibrahim Uygun ◽  
Mehmet Hanifi Okur ◽  
Bahattin Aydogdu ◽  
Yilmaz Arayici ◽  
Burak Isler ◽  
...  
Keyword(s):  
Urinary Stone ◽  
Laser Lithotripsy ◽  
Efficacy And Safety ◽  
Endoscopic Laser ◽  
Stone Treatment

scholarly journals Efficacy and safety of endoscopic laser lithotripsy and lithotomy through the lumen-apposing metal stent for giant gallbladder stones

VideoGIE ◽  
2020 ◽  
Vol 5 (7) ◽  
pp. 318-323
Author(s):  
Wei Wang ◽  
Bowei Liu ◽  
Ke Qi ◽  
Xingang Shi ◽  
Zhendong Jin ◽  
...  
Keyword(s):  
Laser Lithotripsy ◽  
Efficacy And Safety ◽  
Metal Stent ◽  
Gallbladder Stones ◽  
Endoscopic Laser

ОЦЕНКА ЭФФЕКТИВНОСТИ И БЕЗОПАСНОСТИ 10% ВНУТРИВЕННОГО ИММУНОГЛОБУЛИНА ПРИВИДЖЕН В РЕАЛЬНОЙ КЛИНИЧЕСКОЙ ПРАКТИКЕ

2019 ◽  
Author(s):  
L.G. Khludova ◽  
I.A. Manto ◽  
E.A. Latysheva ◽  
T.V. Latysheva ◽  
M.R. Khaitov
Keyword(s):  
Replacement Therapy ◽  
Primary Immunodeficiency ◽  
Adverse Reactions ◽  
Efficacy And Safety ◽  
High Efficacy ◽  
Antibody Synthesis ◽  
Human Immunoglobulins ◽  
Severe Adverse Reactions ◽  
Common Variable ◽  
Real Clinical Practice

Актуальность. Заместительная терапия иммуноглобулинами человека является ведущим патогенетическим методом лечения первичных иммунодефицитов с нарушением синтеза антител. В настоящее время в России доступно несколько препаратов иммуноглобулинов человека нормальных для внутривенного введения. Цель. Оценить эффективность и безопасность препарата Привиджен (10 раствор иммуноглобулина для внутривенного введения) в реальной клинической практике в течение 12 клинических месяцев. Материалы и методы. 20 взрослых с диагнозом общая вариабельная иммунная недостаточности и Х-сцепленная агаммаглобулинемия получали внутривенный иммуноглобулин Привиджен к интервалом 243 дня в течение 12 мес. Первичными критериями оценки была частота инфекционных осложнений и нежелательных явлений. Результаты. У большинства пациентов в ходе исследования достигнут удовлетворительный претранс-фузионный уровень IgG. Тяжелых нежелательных явлений, связанных с введением препарата, не зарегистрировано. Заключение. В ходе исследования препарат продемонстрировал высокую эффективность и безопасность у пациентов, нуждающихся в ежемесячной заместительной терапииRelevance. Replacement therapy with human immunoglobulins is the leading pathogenetic method of treatment of primary immunodeficiency with impaired antibody synthesis. Currently, several preparations of human immunoglobulins for intravenous administration are available in Russia. Purposes. Evaluation of the efficacy and safety of Privigen immunoglobulin intravenous 10 liquid in real clinical practice within 12 clinical months. Methods. Twenty adults diagnosed with common variable immunodeficiency or X-linked agammaglobulinemia received intravenous Privigen infusions (0.2-0.4 mg/kg) at 243 intervals over a 12-month period. The primary endpoint was the annual rate of infections and adverse events. Results. Sufficient level of IgG was achieved in most patients during the study. Severe adverse reactions during the treatment were not registered. Conclusions. High efficacy and safety of monthly replacement therapy in patients with primary immunodeficiency with impaired antibody synthesis has been demonstrated.

scholarly journals A Novel Technique of Ultra-Mini-Percutaneous Nephrolithotomy: Introduction and an Initial Experience for Treatment of Upper Urinary Calculi Less Than 2 cm

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Janak Desai ◽  
Guohua Zeng ◽  
Zhijian Zhao ◽  
Wen Zhong ◽  
Wenzhong Chen ◽  
...  
Keyword(s):  
Percutaneous Nephrolithotomy ◽  
Urinary Calculi ◽  
Renal Stones ◽  
Laser Lithotripsy ◽  
Complication Rates ◽  
Modified Technique ◽  
Average Operative Time ◽  
Grade Ii ◽  
The Mean ◽  
Metal Sheath

Objectives. To describe our novel modified technique of ultra-mini-percutaneous nephrolithotomy (UMP) using of a novel 6 Fr mininephroscope through an 11–13 Fr metal sheath to perform holmium: YAG laser lithotripsy.Methods. The medical records of 36 patients with moderate-sized (<20 mm) kidney stones treated with UMP from April to July 2012 were retrospectively reviewed. Patients were assessed at the 1st day and 1st month postoperatively by KUB and US to assess stone-free status.Results. The mean stone size was 14.9 ± 4.1 mm (rang: 6–20). The average operative time was 59.8 ± 15.9 (30–90) min. The stone-free rate at postoperative 1st day and 1st month was 88.9% and 97.2%. The mean hospital stay was 3.0 ± 0.9 (2–5) days. Complications were noted in 6 (16.7%) cases according to the Clavien classification, including sepsis in 2 (5.6%) cases (grade II), urinary extravasations in 1 (2.8%) case (grade IIIa), and fever in 3 (8.3%) cases (grade II). No patients needed blood transfusion.Conclusions. UMP is technically feasible, safe, and efficacious for moderate-sized renal stones with an advantage of high stone-free rates and low complication rates. However, due to the limits of its current unexplored indications, UMP is therefore a supplement to, not a substitute for, the standard mini-PCNL technology.

Efficacy and safety of laser lithotripsy in fragmentation of urocystoliths and urethroliths for removal in dogs

2009 ◽  
Vol 234 (10) ◽  
pp. 1279-1285 ◽  
Author(s):  
Jody P. Lulich ◽  
Carl A. Osborne ◽  
Hasan Albasan ◽  
Manoj Monga ◽  
John M. Bevan
Keyword(s):  
Laser Lithotripsy ◽  
Efficacy And Safety

scholarly journals Golimumab in the treatment of extra-skeletal manifestations of ankylosing spondylitis

2019 ◽  
Vol 13 (4) ◽  
pp. 110-115
Author(s):  
A. B. Demina
Keyword(s):  
Ankylosing Spondylitis ◽  
Observational Studies ◽  
Clinical Manifestations ◽  
Large Sample Size ◽  
Efficacy And Safety ◽  
High Efficacy ◽  
Treatment Regimens ◽  
Insufficient Response ◽  
Inflammatory Changes

Extra-skeletal manifestations (EMs) of ankylosing spondylitis (AS) can occur and proceed in parallel with inflammatory changes in the joints and spine and often dominate in the clinical picture of AS, determining its high activity and significantly worsening the quality of life in patients. In a number of cases, EMs are characterized by an insufficient response to standard anti-inflammatory therapy for back pain, arthritis, and enthesitis; and there is a need to prescribe another class of drugs.The review highlights the results of studies evaluating the efficacy of golimumab (GLM) in treating EMs in patients with AS: uveitis (GO-EASY Study) and ulcerative colitis (UC) (PURSUIT-SC, PURSUIT-M studies). Analysis of these studies have shown the high efficacy and safety of GLM in reducing the clinical manifestations of AS and in preventing the exacerbations of uveitis and UC. However, despite the successes achieved in treating AS and its EMs, there are many unresolved issues, including those related to the elaboration of optimal treatment regimens, which required longer observational studies with a large sample size.

scholarly journals Extending Coronectomy Indications to Third Molars with Taurodontism to Prevent Paresthesia and Mandible Fracture

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Polianne Alves Mendes ◽  
Isabela Moreira Neiva ◽  
Cláudia Borges Brasileiro ◽  
Ana Cristina Rodrigues Antunes Souza ◽  
Leandro Napier Souza
Keyword(s):  
High Risk ◽  
Female Patient ◽  
Postoperative Period ◽  
Simple Technique ◽  
Mandibular Fracture ◽  
The Body ◽  
Third Molars ◽  
Mandible Fracture ◽  
Angle Fracture

Taurodontism is considered a dental anomaly responsible for a morphoanatomical change in the shape of the tooth in which the roots are reduced in size but the body of the tooth is enlarged and bulky. The aim of this paper is to present a case of a 25-year-old female patient with taurodontism of mandibular partially erupted third molars, presenting a high risk of angle fracture and paresthesia in case of their removal, treated by means of coronectomy. The postoperative period was uneventful and the patient remained in follow-up for 12 months. In conclusion, the identification of third molars with higher risk of complications related to their extractions is the key to consider conservative measures to avoid problems. Coronectomy is a relatively simple technique that should be taken into account when considering bulky, deeply located third molars with a high risk of paresthesia or mandibular fracture, even in presence of taurodontism.

Efficacy and safety of peroral cholangioscopy with intraductal lithotripsy for difficult biliary stones: a systematic review and meta-analysis

Endoscopy ◽  
2020 ◽  
Author(s):  
Thomas R. McCarty ◽  
Rishabh Gulati ◽  
Tarun Rustagi
Keyword(s):  
Adverse Events ◽  
Meta Analysis ◽  
Laser Lithotripsy ◽  
Efficacy And Safety ◽  
Procedure Time ◽  
Single Session ◽  
Biliary Stones ◽  
Peroral Cholangioscopy ◽  
Stone Fragmentation ◽  
Fragmentation Rate

Abstract Background Peroral cholangioscopy with intraductal lithotripsy facilitates optically guided stone fragmentation of difficult biliary stones refractory to conventional endoscopic therapy. The aim of this study was to evaluate the efficacy and safety of peroral cholangioscopy with intraductal lithotripsy for difficult biliary stones. Methods Searches of PubMed, EMBASE, Web of Science, and Cochrane databases were performed in accordance with PRISMA and MOOSE guidelines. Measured outcomes included overall fragmentation success, single-session fragmentation and duct clearance, and rate of adverse events. Sensitivity and subgroup analyses were performed based upon cholangioscopy technique and type of lithotripsy (laser versus electrohydraulic). Heterogeneity was assessed with I 2 statistics. Publication bias was ascertained by funnel plot and Egger regression testing. Results 35 studies were included with 1762 participants (43.4 % men; mean age 61.5 [standard deviation (SD) 11.0]). Prior cholecystectomy had been performed in 37 % of patients, with a mean number of 1.6 (SD 0.5) ERCPs performed prior to lithotripsy. Mean stone size was 1.8 (SD 0.3) cm. Peroral cholangioscopy with intraductal lithotripsy achieved an overall stone fragmentation success of 91.2 % (95 %CI 88.1 % – 93.6 %; I 2 = 63.2 %) with an average of 1.3 [SD 0.6] lithotripsy sessions performed. Complete single-session fragmentation success was 76.9 % (95 %CI 71.6 % – 81.4 %; I 2 = 74.3 %). The adverse events rate was 8.9 % (95 %CI 6.5 % – 12.2 %; I 2 = 60.6 %). Mean procedure time for peroral cholangioscopy was 67.1 (SD 21.4) minutes. There was no difference in overall fragmentation rate or adverse events; however, laser lithotripsy was associated with a higher single-session fragmentation rate and shorter procedure time compared with electrohydraulic lithotripsy. Conclusions Peroral cholangioscopy with intraductal lithotripsy appears to be a relatively safe and effective modality for difficult biliary stones.

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