scholarly journals The Impact of Total Immunoglobulin E Levels on Outcomes of Maximal Medical Therapy for Chronic Rhinosinusitis

2017 ◽  
Vol 8 (1) ◽  
pp. ar.2017.8.0188
Author(s):  
Ana M. Lemos-Rodriguez ◽  
Zainab Farzal ◽  
Satyan B. Sreenath ◽  
Brian D. Thorp ◽  
Brent A. Senior ◽  
...  
2019 ◽  
Vol 99 (3) ◽  
pp. 159-164
Author(s):  
Zhenxiao Huang ◽  
Jingying Ma ◽  
Yan Sun ◽  
Bing Zhou

The aim of the present study was to evaluate the clinical practice patterns in maximal medical therapy (MMT) before endoscopic sinus surgery for chronic rhinosinusitis (CRS) by Chinese otolaryngologists. An anonymous web-based survey of MMT was performed. This survey assessed types of therapies, the frequency of use, duration of use, and demographic data of respondents. A total of 134 (26.8%) questionnaires were completed and returned. The majority (62.69%) of respondents would consider surgery less than 3 months after commencing MMT, 33.58% would wait 3 to 6 months. Intranasal corticosteroid sprays, saline irrigation, oral antibiotics, oral mucolytics, and oral Chinese herbals were the most commonly used therapies and listed as “often (>70%)”. Macrolides were most commonly antibiotics prescribed among the clinicians surveyed (51.49%). Intranasal corticosteroid sprays, oral antibiotics, oral mucolytics, nasal saline irrigations, and oral Chinese herbals are most commonly prescribed by the majority of Chinese otolaryngologists as MMT for CRS. Current practice patterns of MMT among Chinese otolaryngologists are not uniformly based on evidence-based guidelines.


2007 ◽  
Vol 21 (4) ◽  
pp. 483-488 ◽  
Author(s):  
Marc G. Dubin ◽  
Cindy Liu ◽  
Sandra Y. Lin ◽  
Brent A. Senior

Background “Maximal medical therapy” is the standard of care for chronic rhinosinusitis (CRS) treatment before the recommendation for surgery. However, this therapy is not consistent. Therefore, as a first step in determining the role of the disparate “maximal medical” treatments for CRS, American Rhinologic Society (ARS) members were surveyed. Methods A survey was mailed to all nonresident members of the ARS (n = 723). Focusing on the time period before surgical intervention is first considered for CRS patients, the survey assessed types of therapies, frequency of use, details on antibiotic and steroid usage, use of computed tomography (CT), and demographic data of respondents. All responses were anonymous. Results Three hundred eight surveys were returned (43%). A majority of respondents used oral antibiotics and nasal steroids “almost always (>90%).” Oral antibiotics, oral steroids, nasal steroids, saline irrigation, and allergy testing were most commonly used at least “usually (50–90%).” The median antibiotic length was 3.1–4 weeks. The mean peak prednisone dose was 51.7 mg when oral steroids were used. Therapies that were rarely or never used by the majority included oral antifungals, antifungal spray, antibiotic spray, antibiotic nebulizer, steroid nebulizer, and i.v. antibiotics. Conclusion Oral antibiotics (median, 3.1–4 weeks) and nasal steroids are used >90% of the time by a majority of ARS members for maximal medical treatment of CRS.


2019 ◽  
Vol 9 (7) ◽  
pp. 738-745 ◽  
Author(s):  
Nicholas R. Rowan ◽  
Rodney J. Schlosser ◽  
Kristina A. Storck ◽  
Kimia G. Ganjaei ◽  
Zachary M. Soler

Author(s):  
Seema Patel ◽  
Tanvi S. Rekhade ◽  
Rameshwar T. Pawar ◽  
Ashok Z. Nitnaware

<p class="abstract"><strong>Background:</strong> Management protocols of chronic rhinosinusitis (CRS) recommend initial treatment with maximal medical therapy with surgery reserved for refractory cases. Literature comparing the effectiveness of these two treatment modalities is limited. The purpose of this study was to compare the outcome of medical and surgical management for CRS.</p><p class="abstract"><strong>Methods:</strong> This was a prospective cohort study. Patients registered for the study were diagnosed as CRS based on history, clinical examination and investigation findings. All patients were initially subjected to medical management for 3 weeks and refractory cases were then subjected to surgical intervention. Subjective and objective improvements assessed with SNOT-22 score and Lund-Kennedy (LK) score respectively were analysed statistically.</p><p class="abstract"><strong>Results:</strong> Out of the 100 patients registered for the study, 37% had nasal polyposis while 63% were without polyposis. When subjective and objective improvements were compared between groups receiving medical management alone and those receiving combined management, the difference was not found to be statistically significant (p&lt;0.05).</p><p class="abstract"><strong>Conclusions:</strong> Although the decision regarding treatment modality to be used in CRS should depend on individual case, all cases can be subjected to a maximal medical therapy initially while reserving surgery for cases which do not improve.</p>


Author(s):  
Garima Yadav ◽  
Mayank Yadav ◽  
Deeksha Nautiyal ◽  
T. S. Anand

<p class="abstract"><strong>Background: </strong>Chronic rhinosinusitis (CRS) is defined as inflammation of the nasal cavity and paranasal sinuses. Azithromycin, a macrolide antibiotic, a well-established class of anti-bacterial agents, which also have anti-inflammatory properties. The present study was designed to compare the role of azithromycin with surgical management in patients with chronic-rhinosinusitis.</p><p class="abstract"><strong>Methods: </strong>The study population included 60 adult patients with symptomatic CRS refractory to 3 weeks of medical therapy. The patients were divided in two groups with 30 patients in each group. One group of patients received oral Azithromycin as main treatment for 12 weeks while the other group of patients underwent sinonasal surgery. Symptom scoring and endoscopic scoring were done previous to the treatment and at 1 month and 3-month follow-ups.</p><p class="abstract"><strong>Results:</strong> A good subjective as well as objective outcome in terms of symptom improvement was obtained with in patients with chronic rhinosinusitis with Surgical intervention as compared to those patients who received long term oral Azithromycin.</p><p class="abstract"><strong>Conclusions: </strong>We advocate that patients suffering from chronic sinonasal disease should be initially targeted with maximal medical therapy using an oral macrolide for at least 3 months. After this patient should be assessed and surgery considered in those cases refractory to medical therapy.</p>


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