129S1/SvlmJ mouse model of impaired fear extinction shows abnormal sleep architecture

2017 ◽  
Vol 5 (Suppl. 1) ◽  
pp. A4.2
Author(s):  
Eva-Maria Fritz
Keyword(s):  
Mouse Model ◽  
Fear Extinction ◽  
Sleep Architecture ◽  
Abnormal Sleep

Abnormal Sleep Architecture and Hippocampal Circuit Dysfunction in a Mouse Model of Fragile X Syndrome

Neuroscience ◽  
2018 ◽  
Vol 384 ◽  
pp. 275-289 ◽  
Author(s):  
Christine E. Boone ◽  
Heydar Davoudi ◽  
Jon B. Harrold ◽  
David J. Foster
Keyword(s):  
Mouse Model ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Sleep Architecture ◽  
Abnormal Sleep

scholarly journals A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain

2019 ◽  
Vol 12 (9) ◽  
pp. dmm038828 ◽  
Author(s):  
Tamio Furuse ◽  
Hiroshi Mizuma ◽  
Yuuki Hirose ◽  
Tomoko Kushida ◽  
Ikuko Yamada ◽  
...  
Keyword(s):  
Mouse Model ◽  
Deficiency Syndrome ◽  
Glucose Kinetics ◽  
Wake Patterns ◽  
Glut1 Deficiency ◽  
Glut1 Deficiency Syndrome ◽  
The Brain ◽  
Abnormal Sleep

Abnormal Sleep Architecture and Refractory Nocturnal Enuresis

2009 ◽  
Vol 182 (4S) ◽  
pp. 1961-1966 ◽  
Author(s):  
Karlien Dhondt ◽  
Ann Raes ◽  
Piet Hoebeke ◽  
Erik Van Laecke ◽  
Charlotte Van Herzeele ◽  
...  
Keyword(s):  
Nocturnal Enuresis ◽  
Sleep Architecture ◽  
Abnormal Sleep

scholarly journals Histone deacetylase inhibitors, glutamatergic drugs and deep brain stimulation rescue resistance to fear extinction in a genetic mouse model

2012 ◽  
Vol 13 (S1) ◽  
Author(s):  
Nigel Whittle ◽  
Claudia Schmuckermair ◽  
Ozge Gunduz Cinar ◽  
Markus Hauschild ◽  
Francesco Ferraguti ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Mouse Model ◽  
Histone Deacetylase ◽  
Brain Stimulation ◽  
Histone Deacetylase Inhibitors ◽  
Fear Extinction ◽  
Genetic Mouse Model ◽  
Deep Brain

Spontaneous Arm Movement Activity during Sleep in Epileptic and Non-Epileptic Patients

2018 ◽  
Vol 80 (3-4) ◽  
pp. 200-206
Author(s):  
Hendrik Schulz ◽  
Jianghai Ruan ◽  
Rüdiger J. Seitz
Keyword(s):  
Arm Movement ◽  
Epileptic Seizures ◽  
Sleep Architecture ◽  
Rapid Eye Movement Sleep ◽  
Movement Activity ◽  
Epileptic Discharges ◽  
Epileptic Patients ◽  
Patients With Epilepsy ◽  
Electroencephalogram Eeg ◽  
Abnormal Sleep

Purpose: Epilepsy has a complex interaction with sleep. The purpose of this study was to explore the relation between spontaneous arm movements and sleep architecture in patients with epilepsy. Methods: This prospective study included 53 patients with suspected epilepsy (44 ± 18 years; 30 females, 23 males) and 55 age-matched patients with non-epileptic seizures (42 ± 15: 27 females, 28 males). Twenty-four-hour-video-electroencephalography recordings were combined with accelerometry of movement activity of both arms using actiwatches. Results: Patients with suspected epilepsy showed a higher occurrence of epileptic discharges (p = 0.0001) and abnormal focal slowing (p = 0.027) in the electroencephalogram (EEG) than the patients with non-epileptic seizures. Also, the epilepsy patients showed a shorter rapid eye movement-sleep duration compared to controls (0.0001). Accelerometry revealed that the patients with epilepsy moved their dominant right arm more frequently during the night (p = 0.014) than the controls, although there was no difference in arm movement activity during day time. Conclusion: The patients with reported epilepsy exhibited higher spontaneous arm movement activity during sleep. This may be related to abnormal sleep architecture or abnormal EEG activity but was not related to epileptic seizures.

scholarly journals Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model

Neuron ◽  
2008 ◽  
Vol 60 (4) ◽  
pp. 598-609 ◽  
Author(s):  
Sara Dossena ◽  
Luca Imeri ◽  
Michela Mangieri ◽  
Anna Garofoli ◽  
Loris Ferrari ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protein Expression ◽  
Transgenic Mouse ◽  
Prion Protein ◽  
Memory Deficits ◽  
Transgenic Mouse Model ◽  
Sleep Patterns ◽  
Abnormal Sleep
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