Synthesis and Characterization of Some New Heterocyclic Derivatives and Studying of their Biological Activity (Anti-Bacteria)

Introduction: In this work synthesis, many kinds of heterocyclic derivatives by many steps, the first we preparation 1-(4-((1H-imidazol_2-yl-) diazenyl) phenyl) ethan-1_one. (1) by coupling of diazonium salt of p-amino acetophenone with imidazole in alkaline alcoholic media, the second step include react (1) with 2_amino_6_methylpyrimidin _4_ol in acid medium to get Schiff base derivatives(2)the last step include react(2) with (sodium azide, thioglycolic acid, glycine, alanine, Tryptophan, (2 aminobenzoic acid), (2-mercaptobenzoic acid) to give (tetrazole(3), thiazolidine(4), imidazolidine(5-7), Thiazinie(8), Quinazoline (9) derivatives, respectively. All these derivatives Characterization by FTIR, 1HNMR, 13C-NMR, After that we studied the biological activity for all derivatives for all derivatives studied the anticancer for (2).

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Study the Biological Activity for Shiff Base and Β – Lactam Compounds that Synthesis and Identification from Pyrimidine Derivatives

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.11.1.12 ◽

2013 ◽

Vol 11 (01) ◽

pp. 37-39

Author(s):

Rawaa Neamah ◽

Shaimaa Adnan

Keyword(s):

Biological Activity ◽

Schiff Base ◽

Acetyl Chloride ◽

Second Step ◽

Pyrimidine Derivatives ◽

H Nmr ◽

Schiff Base Derivatives ◽

Base Derivative ◽

Shiff Base

In This study We are synthesis and characterization of some Schiff base and β- lactam derivatives) by three steps. The First react 2-amino-4-Chloro-6-methyl pyrimidine with 4-amino acetophenone in an acid medium to get shiff base derivative(E)-4-(1-((4-Chloro-6-methyl pyridine-2-yl)imino)ethyl)aniline (1), the second step (1) react with (3,4- dimethoxybenzal dehyde,4-methyl benzaldehyde,4-dimethylamino benzaldehyde,4-bromo benzaldehyde,4–hydroxy benzaldehyde, 4-Nitro benzaldehyde) to get Schiff base derivatives (2-7), the last step (2-7) derivatives react with Chloro acetyl chloride to get –β-lactam derivatives.(8-13) All these compounds are characterization by (FTIR), (1 H-NMR),(13C- NMR). After that study, the biological activity for all these derivatives to word two kinds of bacteria study the Enzymatic and Cancer Cell.

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Synthesis and Characterization of a Novel o-Vanillin Schiff Base Derivatives and Their Complexes With Zn(II)

Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry ◽

10.1080/15533174.2013.796978 ◽

2014 ◽

Vol 44 (6) ◽

pp. 877-880 ◽

Cited By ~ 6

Author(s):

Wen Wu ◽

Yawen Xuan ◽

Jiang Long Yin ◽

Li Shujie

Keyword(s):

Schiff Base ◽

Synthesis And Characterization ◽

Schiff Base Derivatives

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Synthesis and Characterization of some new Formazan Derivatives from 2-Amino-4-Hydroxy-6-Methyl Pyrimidine and Study the Biological Activity (Anti-Bacteria and Anti-Cancer)

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.11.1.8 ◽

2020 ◽

Vol 11 (01) ◽

pp. 53-59

Author(s):

Shaimaa Adnan ◽

Abdullah Shakir

Keyword(s):

Fourier Transform ◽

Biological Activity ◽

Schiff Base ◽

Infrared Spectroscopy ◽

13C Nmr ◽

Synthesis And Characterization ◽

Compound A ◽

Anti Cancer ◽

Base Derivative

This study involves a synthesis of some formazan derivatives starting from react chloro acetyl chlorid with 2-amino-4-hydroxy-6-methyl pyrimidine to gate compound (a), (a) react with hydrazine hydrate to give compound (b) also (b) react with 3-4-dimethoxy benzaldehyd to product Schiff base derivative (c) then (c) react with deferent amin derivatives to get formazan derivatives. All these compounds characterized by 13C-NMR, fourier transform infrared spectroscopy (FTIR), 1HMNR. After that, we study the biological activity for all formazan derivatives toward two different kinds of bacteria and anti-cancer.

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