Complications following upper respiratory tract infections: a population based cohort study in Stockholm County, Sweden

2016 ◽  
Author(s):  
Jenny Hellman
Keyword(s):  
Cohort Study ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Population Based ◽  
Upper Respiratory Tract Infections ◽  
Upper Respiratory Tract ◽  
Stockholm County ◽  
Upper Respiratory ◽  
Tract Infections

scholarly journals The Safety of Delayed Versus Immediate Antibiotic Prescribing for Upper Respiratory Tract Infections

2020 ◽  
Author(s):  
Tjeerd Pieter van Staa ◽  
Victoria Palin ◽  
Benjamin Brown ◽  
William Welfare ◽  
Yan Li ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Hospital Admission ◽  
Respiratory Tract Infections ◽  
Population Based ◽  
Upper Respiratory Tract Infections ◽  
Antibiotic Prescribing ◽  
Upper Respiratory Tract ◽  
Increased Risk ◽  
Upper Respiratory ◽  
Tract Infections

Abstract Background This study aimed to evaluate the clinical safety of delayed antibiotic prescribing for upper respiratory tract infections (URTIs), which is recommended in treatment guidelines for less severe cases. Methods Two population-based cohort studies used the English Clinical Practice Research Databank and Welsh Secure Anonymized Information Linkage, containing electronic health records from primary care linked to hospital admission records. Patients with URTI and prescriptions of amoxicillin, clarithromycin, doxycycline, erythromycin, or phenoxymethylpenicillin were identified. Patients were stratified according to delayed and immediate prescribing relative to URTI diagnosis. Outcome of interest was infection-related hospital admission after 30 days. Results The population included 1.82 million patients with an URTI and antibiotic prescription; 91.7% had an antibiotic at URTI diagnosis date (immediate) and 8.3% had URTI diagnosis in 1–30 days before (delayed). Delayed antibiotic prescribing was associated with a 52% increased risk of infection-related hospital admissions (adjusted hazard ratio, 1.52; 95% confidence interval, 1.43–1.62). The probability of delayed antibiotic prescribing was unrelated to predicted risks of hospital admission. Analyses of the number needed to harm showed considerable variability across different patient groups (median with delayed antibiotic prescribing, 1357; 2.5% percentile, 295; 97.5% percentile, 3366). Conclusions This is the first large population-based study examining the safety of delayed antibiotic prescribing. Waiting to treat URTI was associated with increased risk of hospital admission, although delayed antibiotic prescribing was used similarly between high- and low-risk patients. There is a need to better target delayed antibiotic prescribing to URTI patients with lower risks of complications.

scholarly journals Impact of early daycare on healthcare resource use related to upper respiratory tract infections during childhood: prospective WHISTLER cohort study

BMC Medicine ◽  
2014 ◽  
Vol 12 (1) ◽  
Author(s):  
Marieke LA de Hoog ◽  
Roderick P Venekamp ◽  
Cornelis K van der Ent ◽  
Anne Schilder ◽  
Elisabeth AM Sanders ◽  
...  
Keyword(s):  
Cohort Study ◽  
Respiratory Tract ◽  
Resource Use ◽  
Respiratory Tract Infections ◽  
Healthcare Resource ◽  
Upper Respiratory Tract Infections ◽  
Upper Respiratory Tract ◽  
Healthcare Resource Use ◽  
Upper Respiratory ◽  
Tract Infections
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