The prevalence of neuropathic pain and its impact on the functional capacity and wellbeing of leprosy patients in Indonesia

2016 ◽  
Author(s):  
Norana Abdul Rahman
Keyword(s):  
Neuropathic Pain ◽  
Functional Capacity ◽  
Leprosy Patients

scholarly journals Prevalence and characteristics of neuropathic pain in leprosy patients treated years ago

2014 ◽  
Vol 108 (4) ◽  
pp. 186-190 ◽  
Author(s):  
José Manuel Ramos ◽  
Beatriz Alonso-Castañeda ◽  
Dejene Eshetu ◽  
Deriba Lemma ◽  
Francisco Reyes ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Leprosy Patients

Association Between Neuropathic Pain and A-Waves in Leprosy Patients With Type 1 and 2 Reactions

2011 ◽  
Vol 28 (3) ◽  
pp. 329-332 ◽  
Author(s):  
José A. Garbino ◽  
Bernard Naafs ◽  
Manoel H. Salgado ◽  
Somei Ura ◽  
Marcos da C. L. Virmond ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Leprosy Patients

scholarly journals Histopathological and clinical findings in leprosy patients with chronic neuropathic pain: a study from Hyderabad, India

2007 ◽  
Vol 78 (4) ◽  
pp. 369-380 ◽  
Author(s):  
Caroline Lund ◽  
Mika Koskinen ◽  
Sujai Suneetha ◽  
Diana N. J. Lockwood ◽  
Maija HAANPÄÄ ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Clinical Findings ◽  
Chronic Neuropathic Pain ◽  
Leprosy Patients

scholarly journals Psychological distress and quality of life in leprosy patients with neuropathic pain

2014 ◽  
Vol 85 (3) ◽  
pp. 186-193 ◽  
Author(s):  
Felipe J.J. Reis ◽  
Daiane Lopes ◽  
Jéssica Rodrigues ◽  
Artur Padão Gosling ◽  
Maria Katia Gomes
Keyword(s):  
Quality Of Life ◽  
Neuropathic Pain ◽  
Psychological Distress ◽  
Leprosy Patients

scholarly journals Diagnosis and impact of neuropathic pain in leprosy patients in Nepal after completion of multidrug therapy

2018 ◽  
Vol 12 (7) ◽  
pp. e0006610 ◽  
Author(s):  
Han-Siong Toh ◽  
Jeni Maharjan ◽  
Ruby Thapa ◽  
Kapil Dev Neupane ◽  
Mahesh Shah ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Multidrug Therapy ◽  
Leprosy Patients

scholarly journals POS0565 IS ACTIVE SYNOVITIS OF METACARPOPHALANGEAL JOINTS A NEUROPATHIC CONDITION IN RHEUMATOID ARTHRITIS PATIENTS? RESULTS FROM A ULTRASOUND STUDY AT LEVEL OF THE PALMAR DIGITAL NERVES

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 517-518
Author(s):  
M. Di Carlo ◽  
J. Di Battista ◽  
R. Chiorrini ◽  
E. Cipolletta ◽  
G. Smerilli ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Neuropathic Pain ◽  
Carpal Tunnel Syndrome ◽  
Disease Activity ◽  
Functional Capacity ◽  
Carpal Tunnel ◽  
Clinical Assessment ◽  
Disease Duration ◽  
Tunnel Syndrome ◽  
Active Synovitis

Background:Rheumatoid arthritis (RA) is a chronic inflammatory arthritis that primarily affects the joints of hands, wrists, and feet. Anatomical damage (at bone, cartilage and tendon level) occurs as a consequence of a persistent synovial inflammation (1). In RA, periarticular soft tissues, including nerves, may also be involved. In particular, there is a high prevalence of neuropathic conditions such as carpal tunnel syndrome (CTS) in RA patients. In fact, the presence of inflammatory changes can frequently be documented by ultrasound (US) at the level of median nerve (2). Currently available very-high frequency US transducers allow high spatial resolution of small anatomical structures, including the palmar digital nerves.Objectives:The objectives of this study were: to document the presence of dimensional alterations of the palmar digital nerves, particularly in terms of increased cross-sectional area (CSA), and to determine the variables associated with increased CSA, in RA patients.Methods:From September 2020 to December 2020, adult RA patients from a tertiary outpatient clinic were consecutively included regardless of disease activity status. Patients underwent a clinical assessment to determine disease activity using the Clinical Disease Activity Index (CDAI), functional capacity using the QuickDASH, and the presence of neuropathic pain features using the PainDetect Questionnaire (PDQ). In the same visit, patients underwent a US examination of the 2nd to 5th metacarpophalangeal joints (MCPj) of the clinically more involved hand by an operator blinded to the clinical assessment. The presence/absence and US grading of synovitis was recorded for each joint. A third operator, blinded to the clinical and joint US assessment, measured the CSA of each pair of palmar digital nerves from 2nd to 5th finger scanned for assessment joint involvement. The CSA of the palmar digital nerves was measured at the MCPj. The US examinations were conducted with a MyLab Class C (Esaote, Genoa, Italy), with a 6-18 MHz probe for the articular examination, and with an 10-22 MHz probe for the examination of the palmar digital nerves. The serological status, respectively rheumatoid factor (RF) and anti-citrullinated peptide antibodies (ACPA), and the presence of radiographic erosive disease were also recorded for each patient. Statistical analysis was conducted by considering the sum of the CSA for each nerve pair of each finger. CSA was compared with respect to body mass index (BMI), disease duration, disease activity, US synovitis grading, functional capacity, neuropathic pain features, serological characteristics, and erosive status.Results:Sixty-three patients with RA were included, 48 women, 15 men, with a mean age of 62.2 (11.8, standard deviation [SD]) years, a mean disease duration of 10.9 (8.2) years, for a total of 252 MCPj and 504 palmar digital nerves. The CSA of the palmar digital nerves taken individually was 2.3 (0.9) mm2, ranging from 1 mm2 to 8 mm2, and 4.2 (1.5) mm2 as a pair for finger. There was a statistically significant association with disease activity as assessed by the CDAI (p <0.001), and with the grading of US synovitis (p <0.001), while there were no significant associations with any of the other variables.Conclusion:The presence of active RA, both in terms of clinical and ultrasonographic indices, correlates with an increased CSA of the palmar digital nerves. This alteration is probably due to inflammatory mechanisms of the perineural tissues at the level of the MCPj. Active synovitis during RA can somehow be framed as a condition capable of causing neuropathic damage to the palmar digital nerves.References:[1]Filippucci E, Cipolletta E, Mashadi Mirza R, et al. Ultrasound imaging in rheumatoid arthritis. Radiol Med 2019;124(11):1087-1100.[2]Smerilli G, Di Matteo A, Cipolletta E, et al. Ultrasound assessment of carpal tunnel in rheumatoid arthritis and idiopathic carpal tunnel syndrome. Clin Rheumatol 2020; doi: 10.1007/s10067-020-05293-z.Disclosure of Interests:None declared

scholarly journals Quality of life and functional capacity are adversely affected in osteoarthritis patients with neuropathic pain

2017 ◽  
Vol 33 (3) ◽  
pp. 152-158 ◽  
Author(s):  
Ayhan Aşkın ◽  
Ayten Özkan ◽  
Aliye Tosun ◽  
Ümit Seçil Demirdal ◽  
Fethi İsnaç
Keyword(s):  
Quality Of Life ◽  
Neuropathic Pain ◽  
Functional Capacity

scholarly journals Clinical and Neurophysiological Features of Leprosy Patients with Neuropathic Pain

2018 ◽  
Vol 98 (6) ◽  
pp. 1609-1613 ◽  
Author(s):  
Louise Mara Giesel ◽  
Izabela Jardim Rodrigues Pitta ◽  
Raquel Custódio da Silveira ◽  
Lígia Rocha Andrade ◽  
Robson Teixeira Vital ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Leprosy Patients

scholarly journals Clinical prediction rules for the diagnosis of neuritis in leprosy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Louise Mara Giesel ◽  
Yara Hahr Marques Hökerberg ◽  
Izabela Jardim Rodrigues Pitta ◽  
Lígia Rocha Andrade ◽  
Debora Bartzen Moraes ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Cross Sectional Study ◽  
Neurological Symptoms ◽  
Clinical Predictors ◽  
Chi Square ◽  
Cross Sectional ◽  
Clinical Algorithm ◽  
Exact Test ◽  
Electrophysiological Tests ◽  
Leprosy Patients

Abstract Background Diagnosing neuritis in leprosy patients with neuropathic pain or chronic neuropathy remains challenging since no specific laboratory or neurophysiological marker is available. Methods In a cross-sectional study developed at a leprosy outpatient clinic in Rio de Janeiro, RJ, Brazil, 54 individuals complaining of neural pain (single or multiple sites) were classified into two groups (“neuropathic pain” or “neuritis”) by a neurological specialist in leprosy based on anamnesis together with clinical and electrophysiological examinations. A neurologist, blind to the pain diagnoses, interviewed and examined the participants using a standardized form that included clinical predictors, pain features, and neurological symptoms. The association between the clinical predictors and pain classifications was evaluated via the Pearson Chi-Square or Fisher’s exact test (p < 0.05). Results Six clinical algorithms were generated to evaluate sensitivity and specificity, with 95% confidence intervals, for clinical predictors statistically associated with neuritis. The most conclusive clinical algorithm was: pain onset at any time during the previous 90 days, or in association with the initiation of neurological symptoms during the prior 30-day period, necessarily associated with the worsening of pain upon movement and nerve palpation, with 94% of specificity and 35% of sensitivity. Conclusion This algorithm could help physicians confirm neuritis in leprosy patients with neural pain, particularly in primary health care units with no access to neurologists or electrophysiological tests.

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