Investigation of the effects of early stressful and late maternal separation on anxiety, behaviour,and pain threshold in newborn male and female rats

2016 ◽  
Author(s):  
Asuman Golgeli
Keyword(s):  
Pain Threshold ◽  
Maternal Separation ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

Investigation of the effects of early stressful and late maternal separation on anxiety, behaviour, and pain threshold in newborn male and female rats

2016 ◽  
Vol 26 ◽  
pp. S288-S289
Author(s):  
A. Golgeli ◽  
K. Yazgan ◽  
R.T. Yıldırım ◽  
Z. Ince ◽  
Z. Sarıca ◽  
...  
Keyword(s):  
Pain Threshold ◽  
Maternal Separation ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

Two repeated maternal separation procedures differentially affect brain 5-hydroxytryptamine transporter and receptors in young and adult male and female rats

2009 ◽  
Vol 1305 ◽  
pp. S37-S49 ◽  
Author(s):  
Sadia Oreland ◽  
Chris Pickering ◽  
Camilla Gökturk ◽  
Lars Oreland ◽  
Lotta Arborelius ◽  
...  
Keyword(s):  
Adult Male ◽  
Maternal Separation ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

Neonatal Stress Has a Long-Lasting Sex-Dependent Effect on Anxiety-Like Behavior and Neuronal Morphology in the Prefrontal Cortex and Hippocampus

2018 ◽  
Vol 40 (2) ◽  
pp. 93-103 ◽  
Author(s):  
Silvana Regina de Melo ◽  
Caren Tatiane de David Antoniazzi ◽  
Shakhawat Hossain ◽  
Bryan Kolb
Keyword(s):  
Prefrontal Cortex ◽  
Locomotor Activity ◽  
Maternal Separation ◽  
Early Adulthood ◽  
Insular Cortex ◽  
Neuronal Morphology ◽  
Female Rats ◽  
Spine Density ◽  
Male And Female ◽  
Male And Female Rats

The long-lasting effects of early stress on brain development have been well studied. Recent evidence indicates that males and females respond differently to the same stressor. We examined the chronic effects of daily maternal separation (MS) on behavior and cerebral morphology in both male and female rats. Cognitive and anxiety-like behaviors were evaluated, and neuroplastic changes in 2 subregions of the prefrontal cortex (dorsal agranular insular cortex [AID] and cingulate cortex [Cg3]) and hippocampus (CA1 and dentate gyrus) were measured in adult male and female rats. The animals were subjected to MS on postnatal day (P) 3–14 for 3 h per day. Cognitive and emotional behaviors were assessed in the object/context mismatch task, elevated plus maze, and locomotor activity test in early adulthood (P87–P95). Anatomical assessments were performed in the prefrontal cortex (i.e., cortical thickness and spine density) and hippocampus (i.e., spine density). Sex-dependent effects were observed. MS increased anxiety-related behavior only in males, whereas locomotor activity was higher in females, with no effects on cognition. MS decreased spine density in the AID and increased spine density in the CA1 area in males. Females exhibited an increase in spine density in the Cg3. Our findings confirm previous work that found that MS causes long-term behavioral and anatomical effects, and these effects were dependent on sex and the duration of MS stress.

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