Impact of nicotine consumption on antipsychotic response based on genetic variants of cytochrome P450 2D6 and multi-drug resistance 1 C3435T in schizophrenia

2016 ◽  
Author(s):  
Rosa Catalán
Keyword(s):  
Drug Resistance ◽  
Cytochrome P450 ◽  
Genetic Variants ◽  
Multi Drug Resistance ◽  
Cytochrome P450 2D6 ◽  
Nicotine Consumption ◽  
P450 2D6

Case report: recurrence of Plasmodium vivax malaria due to defective cytochrome P450 2D6 function in Pos Lenjang, Pahang, Malaysia

2020 ◽  
Vol 114 (9) ◽  
pp. 700-703
Author(s):  
Noor Hafizan Mat Salleh ◽  
Mohd Faizal Abdul Rahman ◽  
Samsiah Samsusah ◽  
Jeremy Ryan De Silva ◽  
David Chun-Ern Ng ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cytochrome P450 ◽  
Case Report ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Microsatellite Analysis ◽  
Cytochrome P450 2D6 ◽  
Liver Stage ◽  
Plasmodium Vivax Malaria ◽  
P450 2D6

Abstract Five children in Pos Lenjang, Pahang, Malaysia were PCR-positive for vivax malaria and were admitted to the hospital from 5 to 26 July 2019. One of the patients experienced three episodes of recurrence of vivax malaria. Microsatellite analysis showed that reinfection is unlikely. Drug resistance analysis indicated that Riamet (artemether–lumefantrine) is effective. Cytochrome P450 2D6 (CYP2D6) testing showed that this patient has defective CYP2D6 function. Primaquine failure to clear the Plasmodium vivax hypnozoites may be the cause of recurring infections in this patient. This report highlights the need for the development of liver-stage curative antimalarials that do not require metabolism by the CYP2D6 enzyme.

scholarly journals Bimodal targeting of human cytochrome P450 2D6 to mitochondria and microsomes: A pharmacogenomic approach for identifying genetic variants defective in mitochondrial targeting

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Michelle Cook ◽  
Hindupur Anandatheerthavarada ◽  
Subbuswamy K Prabu ◽  
Peter Frederick Guengerich ◽  
Narayan G Avadhani
Keyword(s):  
Cytochrome P450 ◽  
Genetic Variants ◽  
Cytochrome P450 2D6 ◽  
Mitochondrial Targeting ◽  
Human Cytochrome ◽  
P450 2D6

scholarly journals Genetic variants in the cytochrome P450 2D6 gene in the Sri Lankan population

2013 ◽  
Vol 19 (4) ◽  
pp. 392 ◽  
Author(s):  
VajiraH. W. Dissanayake ◽  
T. D.Praveen Tharanga ◽  
C. M. V. Jinadasa ◽  
MF Risama ◽  
RL Jayakody ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Genetic Variants ◽  
Sri Lankan ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

scholarly journals Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting

2010 ◽  
Vol 99 (1) ◽  
pp. 90-97 ◽  
Author(s):  
Michelle Cook Sangar ◽  
Hindupur K. Anandatheerthavarada ◽  
Martha V. Martin ◽  
F. Peter Guengerich ◽  
Narayan G. Avadhani
Keyword(s):  
Cytochrome P450 ◽  
Genetic Variants ◽  
Cytochrome P450 2D6 ◽  
Mitochondrial Targeting ◽  
Human Cytochrome ◽  
P450 2D6
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