Efficacy and safety of lurasidone in male and female patients with schizophrenia: a pooled analysis of short-term, placebo-controlled studies

Podophyllotoxin solution 0.5 is licensed for use in the treatment of condylomata acuminata genital warts in men in a number of European countries. In some countries, approval also extends to treatment of genital warts in women. This controlled randomized prospective study evaluated the efficacy and safety of a cream formulation of podophyllotoxin at 2 concentrations 0.15 and 0.3 , using 0.5 podophyllotoxin solution as a reference treatment. Two separate studies were initiated, to assess the 3 treatment groups in a male patients, and b female patients. Statistical evaluation was based on a 'response rate' calculated at each clinic visit. The mean 'response rates' in the male patient study at 4 weeks were 75.1 , 79.0 and 85.6 in the 0.15 cream, 0.3 cream and 0.5 solution groups, respectively. The corresponding 'response rates' for the female patient study were 86.2 , 92.6 , and 93.1 , respectively. The relapse rates for both male and female patients were 6.0 in the 0.15 cream group, 8.6 in the 0.3 cream group and 8.6 in the 0.5 solution group. The results show that there were no statistically significant differences between the 3 treatments with regard to both efficacy and safety. This was true for both the male and female patient groups.

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Comparison of short-term outcomes following Roux-en-Y gastric bypass in male and female patients using the MBSAQIP database

Surgery for Obesity and Related Diseases ◽

10.1016/j.soard.2020.04.045 ◽

2020 ◽

Vol 16 (9) ◽

pp. 1236-1241

Author(s):

Alexandra Falvo ◽

Voranaddha Vacharathit ◽

Jason E. Kuhn ◽

Marcus Fluck ◽

Robert M. Cunningham ◽

...

Keyword(s):

Gastric Bypass ◽

Short Term ◽

Male And Female ◽

Female Patients

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Efficacy and Safety of EUS-Guided Choledochoduodenostomy Using Electrocautery-Enhanced Lumen-Apposing Metal Stents (ECE-LAMS) in the Treatment of Biliary Obstruction: A Systematic Review and Meta-Analysis

Canadian Journal of Gastroenterology and Hepatology ◽

10.1155/2021/6696950 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Zuxiang Peng ◽

Shan Li ◽

Yongliang Tang ◽

Wanjie Wei ◽

Ruxian Pi ◽

...

Keyword(s):

Systematic Review ◽

Adverse Events ◽

Biliary Obstruction ◽

Clinical Success ◽

Meta Analysis ◽

Pooled Analysis ◽

Metal Stents ◽

Efficacy And Safety ◽

Short Term

Background. Electrocautery-enhanced lumen-apposing metal stents (ECE-LAMS) have been newly developed to perform EUS-guided choledochoduodenostomy (EUS-CDS), but its benefits and harms remain obscure. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of EUS-CDS using ECE-LAMS. Method. In the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), we searched PubMed, Embase, and Scopus databases through January 1, 2001, and April 27, 2020. The primary outcomes of the pooled analysis were to determine the technical success, clinical success, and overall adverse events rates. The secondary outcomes were pooled rates of short-term and long-term adverse events. Results. Six studies with 270 patients were finally included in this meta-analysis. The pooled rates of technical, clinical success, and adverse events were 95.1% (95% CI = 90.6–97.5%, I2 = 25%), 93.3% (95% CI = 87.4–96.5%, I2 = 28%), and 15.3% (95% CI = 10.6–21.6%, I2 = 13%), respectively. The pooled rates of short-term and long-term adverse events were 3.6% (95% CI = 1.3–9.6%, I2 = 0%) and 11.3% (95% CI = 7.6–16.5%, I2 = 0%), respectively. Conclusion. EUS-CDS using ECE-LAMS provides favorable outcomes in patients with biliary obstruction. It has been associated with a higher success rate and a lower rate of adverse events when compared with the biliary drainage approaches previously used. Large and randomized controlled observational studies are required to further refine the findings in the present analysis.

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