Correlation of visual inspection with cytological and histopathological findings in cervical neoplasia

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2008 ◽  
Vol 47 (170) ◽  
Author(s):  
Pragya Dhaubhadel ◽  
A Vaidya ◽  
P Choudhary

A hospital-based, prospective study was done in 350 women of 20-50 years to compare VIA withPap smear for early detection of cervical dysplasia at Maternity Hospital, Thapathali, from May2004 to December 2004. Pap smear was taken from each woman followed by VIA. Women withpositive VIA and/or positive Pap smear were referred for colposcopy-directed cervical biopsy. Thevariables studied were age group, presenting complaint, age of marriage, parity, smoking habit andappearance of cervix.The incidence of positive VIA and Pap smear was 2.86 and 0.57 respectively. Pelvic pain was themost common presenting complaint. The majority of the women were married before 20 years ofage. All women with either positive VIA and/or Pap smear were of parity two or above. Therewas no significant association between smoking and positive VIA (P=0.699) or Pap smear (P=0.397).Approximately 36.57% of the women screened had abnormal looking cervix. There were two womenwith high grade intraepithelial lesion (HSIL) and both were VIA positive and this was statisticallysignificant (Fischer exact P=0.0007). Of the ten VIA positive women, on histopathological examinationsix showed chronic cervicitis, one acute cervicitis, one showed cervical intraepithelial neoplasia (CIN)II, one had normal finding and one was lost to follow up.VIA as a screening test for cervical neoplasia did not miss any lesion detected by Pap smear andconfirmed by cervical biopsy.Key words: cervical neoplasia, pap smear, visual inspection


2010 ◽  
Vol 111 (2) ◽  
pp. 115-118 ◽  
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Ashrafun Nessa ◽  
Muhammad Anwar Hussain ◽  
Jebun Nessa Rahman ◽  
Mohammad Harun Ur Rashid ◽  
Richard Muwonge ◽  
...  

2004 ◽  
Vol 14 (3) ◽  
pp. 465-469 ◽  
Author(s):  
F. Ghaemmaghami ◽  
N. Behtash ◽  
M. Modares Gilani ◽  
A. Mousavi ◽  
M. Marjani ◽  
...  

2011 ◽  
Vol 37 (12) ◽  
pp. 1802-1806 ◽  
Author(s):  
Malihe Hasanzadeh ◽  
Habibollah Esmaeili ◽  
Samane Tabaee ◽  
Fariba Samadi

2006 ◽  
Vol 10 (3) ◽  
pp. 192
Author(s):  
F. Behtash ◽  
N. Behtash ◽  
M. Modares Gilani ◽  
A. Mousavi ◽  
M. Marjani ◽  
...  

2004 ◽  
Vol 28 (5) ◽  
pp. 345-351 ◽  
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Rengaswamy Sankaranarayanan ◽  
Surendra S. Shastri ◽  
Parthasarathi Basu ◽  
Cédric Mahé ◽  
Ranajit Mandal ◽  
...  

2003 ◽  
Vol 13 (5) ◽  
pp. 626-632 ◽  
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P. S. Basu ◽  
R. Sankaranarayanan ◽  
R. Mandal ◽  
C. Roy ◽  
P. Das ◽  
...  

2017 ◽  
Vol 7 (1) ◽  
pp. 1070-1073 ◽  
Author(s):  
P Sherpa ◽  
AD Pant

Background: Cervical cancer is one of the commonest malignancies and a leading cause of morbidity and mortality among women. The aim of this study was to evaluate the diagnostic value of Papanicolaou (PAP) smear and visual inspection with acetic acid as methods of cervical cancer screening.Materials and Methods: This was a observational cross-sectional study conducted from the period of 2068.11.01 to 2069.11.01. The study population consisted of women with histologically confirmed cervical intraepithelial neoplasia or invasive carcinoma who had undergone prior PAP smear.Results: During the study period 160 patients underwent both PAP smear and cervical biopsy. Of these patients, 49 had a histological diagnosis of cervical intraepithelial neoplasia or invasive carcinoma. The histopathological and cytological diagnoses were compared. Visual inspection with acetic acid status was available for 31 of the 49 cases. The sensitivity of PAP smear was 61%, specificity 97%, positive predictive value 91%, negative predictive value 85% and diagnostic accuracy 86% for detection of cervical neoplasia. Visual inspection with acetic acid had a sensitivity of 74%, specificity 48%, Positive predictive value 64%, Negative predictive value 60% and diagnostic accuracy of 63%. Combining the two procedures increased sensitivity by 26%, Negative predictive value by 11%  and diagnostic accuracy by 2 per cent.Conclusion: PAP smear has a higher specificity, Positive predictive value, Negative predictive value and diagnostic accuracy but lower sensitivity than visual inspection with acetic acid. Visual inspection with acetic acid by itself is not an effective screening method. A combination of PAP smear and visual inspection with acetic acidcan ensure adequate screening of cervical neoplasia.


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