Endoscopic hand suturing for mucosal defect closure after gastric endoscopic submucosal dissection in in vivo animal models and clinical cases

2016 ◽  
Author(s):  
Osamu Goto
Keyword(s):  
Animal Models ◽  
Endoscopic Submucosal Dissection ◽  
Defect Closure ◽  
Submucosal Dissection ◽  
Mucosal Defect ◽  
In Vivo Animal Models ◽  
Clinical Cases

Endoscopic hand-suturing for defect closure after gastric endoscopic submucosal dissection: a pilot study in animals and in humans

Endoscopy ◽  
2017 ◽  
Vol 49 (08) ◽  
pp. 792-797 ◽  
Author(s):  
Osamu Goto ◽  
Motoki Sasaki ◽  
Teppei Akimoto ◽  
Yasutoshi Ochiai ◽  
Yoshiyuki Kiguchi ◽  
...  
Keyword(s):  
Adverse Events ◽  
Endoscopic Submucosal Dissection ◽  
Barbed Suture ◽  
Defect Closure ◽  
Success Rates ◽  
Needle Holder ◽  
In Vivo Models ◽  
Submucosal Dissection ◽  
Clinical Cases

Abstract Background and study aims Mucosal suturing enables reliable and optimal defect closure after endoscopic treatments. We developed and investigated the feasibility of endoscopic hand-suturing (EHS) after gastric endoscopic submucosal dissection (ESD) in porcine in vivo models and in human clinical cases. Patients and methods EHS involving continuous suturing of the mucosal layers using a through-the-scope needle-holder and absorbable barbed suture, was performed after gastric ESD in six live pigs and in eight consecutive patients. Success rates, adverse events, and suture maintenance were subsequently investigated. Results EHS was successfully completed in all six pigs and eight patients (100 %) without severe adverse events. However, at 1 week postoperatively the suture closures had not been maintained in all six porcine cases and in the first four clinical cases. In the later four clinical cases, wider and tight suturing of the mucosal edges ensured that the defects remained closed until postoperative week 4. Conclusion EHS is a feasible procedure that may facilitate secure and refined endoscopic surgeries. Mucosal closure in such cases can be maintained using firm suturing.Clinical trial number: UMIN000017125

scholarly journals Thread-assisted mucosal defect closure using the locking-clip technique after gastric endoscopic submucosal dissection

Endoscopy ◽  
2018 ◽  
Vol 50 (12) ◽  
pp. E342-E343 ◽  
Author(s):  
Tatsuma Nomura ◽  
Akira Kamei ◽  
Shinya Sugimoto ◽  
Tetsuro Harada ◽  
Jun Oyamda
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Defect Closure ◽  
Submucosal Dissection ◽  
Mucosal Defect

877 MUCOSAL DEFECT CLOSURE BY ENDOSCOPIC HAND-SUTURING MAY REDUCE BLEEDING RISK AFTER GASTRIC ENDOSCOPIC SUBMUCOSAL DISSECTION: A MULTICENTER PILOT STUDY

2020 ◽  
Vol 91 (6) ◽  
pp. AB71-AB72
Author(s):  
Osamu Goto ◽  
Tsuneo Oyama ◽  
Hiroyuki Ono ◽  
Akiko Takahashi ◽  
Mitsuhiro Fujishiro ◽  
...  
Keyword(s):  
Pilot Study ◽  
Endoscopic Submucosal Dissection ◽  
Bleeding Risk ◽  
Defect Closure ◽  
Submucosal Dissection ◽  
Mucosal Defect

Efficacy of an over-the-scope clip for preventing adverse events after duodenal endoscopic submucosal dissection: a prospective interventional study

Endoscopy ◽  
2018 ◽  
Vol 50 (05) ◽  
pp. 487-496 ◽  
Author(s):  
Tomoaki Tashima ◽  
Ken Ohata ◽  
Eiji Sakai ◽  
Yoshitsugu Misumi ◽  
Maiko Takita ◽  
...  
Keyword(s):  
Adverse Events ◽  
Endoscopic Submucosal Dissection ◽  
R0 Resection ◽  
Defect Closure ◽  
Submucosal Dissection ◽  
Mucosal Defect ◽  
Over The Scope Clip ◽  
Delayed Perforation ◽  
The Mean ◽  
Severe Adverse Events

Abstract Background Duodenal endoscopic submucosal dissection (ESD) remains technically challenging, with a high risk of severe adverse events. Because exposure of the duodenal post-ESD mucosal defect to pancreatic juice and bile acid reportedly induces delayed perforation and bleeding, we examined whether defect closure using an over-the-scope clip (OTSC) system was useful for preventing postoperative adverse events. Methods From April 2016 to February 2017, a total of 50 consecutive patients with superficial non-ampullary duodenal epithelial tumors (SNADETs) larger than 10 mm, with no more than semi-circumferential spread, were prospectively enrolled in this study. All of the lesions were treated by experienced ESD operators and the post-ESD mucosal defect was closed using OTSCs. Results All of the SNADETs were completely removed by ESD, with an R0 resection rate of 88.0 %. The mean procedure and closure times were 67.3 ± 58.8 minutes and 9.8 ± 7.2 minutes, respectively. Although complete defect closure was achieved in 94.0 % of the patients (47/50), two patients required surgical conversion. Delayed perforation occurred in only one patient (2.1 %), who did not have successful closure of the defect, as misplacement of the OTSC exposed the muscle layer. Meanwhile, delayed bleeding occurred in three patients (6.3 %); however, the bleeding was easily controlled using endoscopic coagulation. The mean duration of postoperative hospitalization was 5.5 ± 7.2 days. Conclusions Prophylactic defect closure using OTSCs may be effective in reducing severe adverse events after duodenal ESD.

scholarly journals Mucosal defect closure after duodenal endoscopic submucosal dissection using the reopenable‐clip over the line method

JGH Open ◽  
2021 ◽  
Author(s):  
Tatsuma Nomura ◽  
Shinya Sugimoto ◽  
Nobuyuki Tsuda ◽  
Ryutaro Matsushima ◽  
Jun Oyamada ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Defect Closure ◽  
Line Method ◽  
Submucosal Dissection ◽  
Mucosal Defect

scholarly journals Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models

mAbs ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1954136
Author(s):  
Sujatha Kumar ◽  
Srimoyee Ghosh ◽  
Geeta Sharma ◽  
Zebin Wang ◽  
Marilyn R. Kehry ◽  
...  
Keyword(s):  
Animal Models ◽  
Immune Function ◽  
Cellular Assays ◽  
In Vivo Animal Models

Efficacy of soap and water based skin decontamination using in vivo animal models: a systematic review

2021 ◽  
pp. 1-12
Author(s):  
Anuk Burli ◽  
Nadia Kashetsky ◽  
Aileen Feschuk ◽  
Rebecca M. Law ◽  
Howard I. Maibach
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Water Based ◽  
In Vivo Animal Models ◽  
Skin Decontamination
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