Dissolution Method Development and Validation for a Poorly Soluble Drug

2016 ◽  
Author(s):  
Mingkun Fu
Keyword(s):  
Method Development ◽  
Dissolution Method ◽  
Poorly Soluble ◽  
Method Development And Validation ◽  
Poorly Soluble Drug ◽  
Development And Validation

scholarly journals Development and Validation of a Discriminating In Vitro Dissolution Method for a Poorly Soluble Drug, Olmesartan Medoxomil: Comparison Between Commercial Tablets

2010 ◽  
Vol 11 (2) ◽  
pp. 637-644 ◽  
Author(s):  
Lisiane Bajerski ◽  
Rochele Cassanta Rossi ◽  
Carolina Lupi Dias ◽  
Ana Maria Bergold ◽  
Pedro Eduardo Fröehlich
Keyword(s):  
Olmesartan Medoxomil ◽  
In Vitro Dissolution ◽  
Dissolution Method ◽  
Poorly Soluble ◽  
Poorly Soluble Drug ◽  
Development And Validation

Analytical Method Development and Validation of a Dissolution Method for Aliskiren Hemifumarate and Hydrochlorthiazide in Bulk and in Combined Tablet Dosage From by UPLC

2017 ◽  
Vol 7 (1) ◽  
pp. 86-96
Author(s):  
Anandakumar Karunakaran ◽  
Vidhya Arthy Jaganathan ◽  
Ananda Thangadurai Subramanian ◽  
Jambulingam Munusamy ◽  
Kamalakannan Dhanapalan
Keyword(s):  
Analytical Method ◽  
Method Development ◽  
Dissolution Method ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Tablet Dosage

scholarly journals Discriminatory Dissolution Method Development and Validation of Etoricoxib Tablets

2016 ◽  
Vol 23 (2) ◽  
pp. 30-34 ◽  
Author(s):  
Yasvanth Ashokraj ◽  
Atul Daroi ◽  
Raja Gupta ◽  
Aruna Khanolkar ◽  
Amol Kulkarni ◽  
...  
Keyword(s):  
Method Development ◽  
Dissolution Method ◽  
Method Development And Validation ◽  
Development And Validation

scholarly journals Dissolution Method Development and Validation for Estimation of Noscapine Tablets

2020 ◽  
Vol 10 (1-s) ◽  
pp. 159-164
Author(s):  
Jigar Vyas ◽  
Jaydip Solanaki ◽  
Kapil Daxini ◽  
Puja Vyas ◽  
Neha Pal
Keyword(s):  
Method Development ◽  
Uv Spectrophotometry ◽  
Dissolution Test ◽  
Dissolution Medium ◽  
Dissolution Method ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Usp Apparatus ◽  
Usp Apparatus 2

A dissolution method was developed and UV spectrophotometry was developed for the evaluation of the dissolution of tablets containing 15 mg Noscapine .The dissolution medium 0.1 N HCl was found suitable to ensure sink conditions. USP Apparatus 2, 900 mL dissolution medium 45 minutes and 100 RPM were fixed. Dissolution profiles were generated at 10, 15, 20,   30; 45 min. Dissolution samples were analyzed with UV spectrophotometer at 213 nm. The UV method for determination of tablet was developed and validated. The method presented linearity (R2 = 0.999) in the concentration range of 1–9 μg/mL. The recoveries were good, ranging from 97.18% to 101.45%. The intraday and Interday precision results were 0.54% and 0.78% RSD, respectively. The developed dissolution test is adequate for its purpose and can be applied for the quality control of tablets. Keywords: Dissolution test; Noscapine; Tablets; UV Spectrophotometry method

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