The Effect of Apolipoprotein E Ɛ4 (APOE Ε4) on Visuospatial Working Memory in Healthy Elders and Amnestic Mild Cognitive Impairment Patients: an Event-related Potentials Study

2017 ◽  
Author(s):  
Lihua Gu
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Apolipoprotein E ◽  
Event Related Potentials ◽  
Amnestic Mild Cognitive Impairment ◽  
Visuospatial Working Memory ◽  
Apoe Ε4 ◽  
Related Potentials

[P3-361]: DIFFERENCES BETWEEN HEALTHY AND AMNESTIC MILD COGNITIVE IMPAIRMENT ADULTS IN EVENT-RELATED POTENTIALS DURING MEMORY ENCODING IN A VISUOSPATIAL WORKING MEMORY TASK

2017 ◽  
Vol 13 (7S_Part_22) ◽  
pp. P1094-P1094
Author(s):  
Alba Fernández ◽  
Fernando Díaz ◽  
Mónica Lindín ◽  
Santiago Galdo-Álvarez ◽  
Montserrat Zurrón
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Task ◽  
Event Related Potentials ◽  
Amnestic Mild Cognitive Impairment ◽  
Memory Encoding ◽  
Visuospatial Working Memory ◽  
Related Potentials

scholarly journals Altered Neural Activity during Semantic Object Memory Retrieval in Amnestic Mild Cognitive Impairment as Measured by Event-Related Potentials

2015 ◽  
Vol 46 (3) ◽  
pp. 703-717 ◽  
Author(s):  
Hsueh-Sheng Chiang ◽  
Raksha A. Mudar ◽  
Athula Pudhiyidath ◽  
Jeffrey S. Spence ◽  
Kyle B. Womack ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Neural Activity ◽  
Memory Retrieval ◽  
Event Related Potentials ◽  
Amnestic Mild Cognitive Impairment ◽  
Object Memory ◽  
Related Potentials ◽  
Semantic Object

The Effect of Apolipoprotein E ɛ4 (APOE E4) on Visuospatial Working Memory in Healthy Elders and Amnestic Mild Cognitive Impairment Patients: An Event-related Potentials Study

2017 ◽  
Vol 41 (S1) ◽  
pp. S171-S172 ◽  
Author(s):  
L. Gu
Keyword(s):  
Working Memory ◽  
Apolipoprotein E ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Parahippocampal Gyrus ◽  
Time Range ◽  
Visuospatial Working Memory ◽  
Related Potentials ◽  
Competing Interest

IntroductionPrevious studies provided inconsistent evidences for the effect of apolipoprotein E ɛ4 (APOE ɛ4) status on the visuospatial working memory (VSWM). Our study was the first investigation with event-related potential (ERP) to explore the effect of APOE ɛ4 on VSWM in healthy elders and aMCI patients.ObjectiveThe aim was to investigate the effect of APOE ɛ4 on VSWM with event-related potential (ERP) study in healthy elders and aMCI patients.MethodsThirty-nine aMCI patients (27 APOE ɛ4 non-carriers and 12 APOE ɛ4 carriers) and 43 their matched control (25 APOE ɛ4 non-carriers and 18 APOE ɛ4 carriers) performed an N-back task, a VSWM paradigm that manipulated the number of items to be stored in memory.ResultsOur study detected reduced accuracy and delayed mean correct response time in aMCI patients than healthy elders. P300 was elicited by VSWM and its amplitude was lower in aMCI patients at the central-parietal and parietal electrodes than healthy controls. In healthy elders, P300 amplitude declined prior to task performance change in APOE ɛ4 carriers than non-carriers. Regarding aMCI patients, P300 amplitude result revealed exacerbated VSWM deficits in APOE ɛ4 carriers than APOE ɛ4 non-carriers. Additionally, standardized low-resolution brain electromagnetic tomography analysis (s-LORETA) result showed enhanced brain activation in right parahippocampal gyrus during P300 time range in APOE ɛ4 carriers than non-carriers in aMCI patients (Fig. 1, Tables 1 and 2).ConclusionsIt demonstrated that P300 amplitude might serve as a biomarker for recognizing aMCI patients and contribute to early detection of worse VSWM in APOE ɛ4 carriers than non-carriers.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

Selective Impairment of Optic Flow Perception in Amnestic Mild Cognitive Impairment: Evidence From Event-Related Potentials

2012 ◽  
Vol 28 (3) ◽  
pp. 695-708 ◽  
Author(s):  
Takao Yamasaki ◽  
Yoshinobu Goto ◽  
Yasumasa Ohyagi ◽  
Akira Monji ◽  
Shinji Munetsuna ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Optic Flow ◽  
Event Related Potentials ◽  
Amnestic Mild Cognitive Impairment ◽  
Related Potentials ◽  
Selective Impairment

Event-related potentials elicited during working memory are altered in mild cognitive impairment

2016 ◽  
Vol 109 ◽  
pp. 1-8 ◽  
Author(s):  
Rocío A. López Zunini ◽  
Frank Knoefel ◽  
Courtney Lord ◽  
Fiatsogbe Dzuali ◽  
Michael Breau ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Event Related Potentials ◽  
Related Potentials
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