EFFECT OF TRANSDERMAL GLYCERYL TRINITRATE ON BLOOD PRESSURE: RELATIONSHIP WITH HYDRATION STATUS

2017 ◽  
Author(s):  
Zhe Kang Law
Keyword(s):  
Blood Pressure ◽  
Glyceryl Trinitrate ◽  
Hydration Status

scholarly journals Hydration status and blood pressure variability in primary hypertensive patients

2020 ◽  
Vol 40 (5) ◽  
pp. 522-530
Author(s):  
Oguzhan Sıtkı Dizdar ◽  
Ali Yeşiltepe ◽  
Engin Dondurmaci ◽  
Eyup Ozkan ◽  
Ali Koç ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Hydration Status ◽  
Hypertensive Patients

24-Hour Ambulatory Blood Pressure Monitoring: A Comparison Between Transdermal Glyceryl-Trinitrate and Oral Nifedipine

1999 ◽  
Vol 18 (1) ◽  
pp. 107-113 ◽  
Author(s):  
Isabella Neri ◽  
Herbert Valensise ◽  
Fabio Facchinetti ◽  
Simona Menghini ◽  
Carlo Romanini ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Glyceryl Trinitrate ◽  
Ambulatory Blood Pressure Monitoring ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Pressure Monitoring

scholarly journals Baseline characteristics of the 1149 patients recruited into the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) randomized controlled trial

2018 ◽  
Vol 14 (3) ◽  
pp. 298-305 ◽  
Author(s):  
Philip M Bath ◽  
Polly Scutt ◽  
Jason P Appleton ◽  
Mark Dixon ◽  
Lisa J Woodhouse ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Glyceryl Trinitrate ◽  
Acute Stroke ◽  
Controlled Trial ◽  
Nitric Oxide Donor ◽  
Main Trial ◽  
Randomized Controlled ◽  
Baseline Characteristics ◽  
The Uk ◽  
Stroke Trial

Background High blood pressure is common in acute stroke and associated with a worse functional outcome. Glyceryl trinitrate, a nitric oxide donor, lowers blood pressure in acute stroke and may improve outcome. Aims Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) tested the feasibility of performing a UK multicenter ambulance-based stroke trial, and the safety and efficacy of glyceryl trinitrate when administered by paramedics before hospital admission. Methods Paramedic-led ambulance-based multicenter prospective randomized single-blind blinded-endpoint parallel-group controlled trial of transdermal glyceryl trinitrate (given for four days) versus sham in patients with ultra-acute (<4 h) presumed stroke. Data are number (%), median (interquartile range) or mean (standard deviation). Results Recruitment ran from October 2015 to 31 May 2018. A total 1149 patients were recruited from eight UK ambulance services and taken to 54 acute hospitals. Baseline characteristics include: mean age 73 (15) years; female 555 (48%); median time from stroke to randomization 70 (45, 115) min; face-arm-speech scale score 2.6 (0.5); and blood pressure 162 (25)/92 (18) mmHg. The final diagnosis was ischemic stroke 52%, hemorrhagic stroke 13%, Transient Ischemic Attack (TIA) 9%, and mimic 25%. The main trial results will be presented in quarter 4 2018. The results will also be included in updated Cochrane systematic reviews, and individual patient data meta-analyses of all relevant randomized controlled trials. Conclusion It was feasible to perform a multicenter ambulance-based ultra-acute stroke trial in the UK and to treat with glyceryl trinitrate versus sham. The relatively unselected cohort of stroke patients is broadly representative of those admitted to hospital in the UK. Trial registration ISRCTN26986053.

scholarly journals Hydration Status Is Associated with Aortic Stiffness, but Not with Peripheral Arterial Stiffness, in Chronically Hemodialysed Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Daniel Bia ◽  
Cintia Galli ◽  
Rodolfo Valtuille ◽  
Yanina Zócalo ◽  
Sandra A. Wray ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Body Fluid ◽  
Fluid Management ◽  
Blood Pressure Level ◽  
Whole Body ◽  
Volume Status ◽  
Hydration Status ◽  
Fluid Status ◽  
Peripheral Arterial

Background. Adequate fluid management could be essential to minimize high arterial stiffness observed in chronically hemodialyzed patients (CHP).Aim. To determine the association between body fluid status and central and peripheral arterial stiffness levels.Methods. Arterial stiffness was assessed in 65 CHP by measuring the pulse wave velocity (PWV) in a central arterial pathway (carotid-femoral) and in a peripheral pathway (carotid-brachial). A blood pressure-independent regional arterial stiffness index was calculated using PWV. Volume status was assessed by whole-body multiple-frequency bioimpedance. Patients were first observed as an entire group and then divided into three different fluid status-related groups: normal, overhydration, and dehydration groups.Results. Only carotid-femoral stiffness was positively associated (P<0.05) with the hydration status evaluated through extracellular/intracellular fluid, extracellular/Total Body Fluid, and absolute and relative overhydration.Conclusion. Volume status and overload are associated with central, but not peripheral, arterial stiffness levels with independence of the blood pressure level, in CHP.

Usefulness of tilt test–induced patterns of heart rate and blood pressure using a two-stage protocol with glyceryl trinitrate provocation in patients with syncope of unknown origin

1999 ◽  
Vol 84 (6) ◽  
pp. 665-670 ◽  
Author(s):  
Arvinder S Kurbaan ◽  
Ann-Christine Franzén ◽  
Timothy J Bowker ◽  
Timothy R Williams ◽  
Samer Kaddoura ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Glyceryl Trinitrate ◽  
Unknown Origin ◽  
Tilt Test ◽  
Two Stage

scholarly journals The psychophysiological effects of a three day dry fast: A self-experimentation case study

2020 ◽  
Author(s):  
Harriet Carroll
Keyword(s):  
Blood Pressure ◽  
Blood Glucose ◽  
Specific Gravity ◽  
Sleep Quality ◽  
Body Mass ◽  
Urine Volume ◽  
Urine Specific Gravity ◽  
Hydration Status ◽  
Fluid Restriction ◽  
Urine Colour

Background: A commonly held belief is that humans cannot survive more than a few days without fluid intake. The source of this is unclear, but does not accord with the few controlled studies that have been conducted to investigate the effects of fluid abstention, nor the few extreme cases of fluid restriction. Methods: This was a self-experimentation, with one day pre-load of fluid and salt (DAY 0), three days complete fluid abstention (&lt; 45 g/d water from food only) (DAYS 1-3), and 24 h rehydration (DAY 4). Days ran from 1500 h to 1500 h. The following measures were taken across various time points across each day: body mass; urine volume; urine colour; urine specific gravity; finger-prick blood glucose concentration; blood pressure; pulse; body temperature; dietary intake; and visual analogue scales (VAS) of food-appetites (satiety and desires), thirst-appetites, mood, wakefulness, and sleep quality. Results: By the end of DAY 3, body water (excluding estimated lean/adipose loss from negative energy balance) decreased by ~1.8 % from 1500 h on DAY 0, or ~4.0 % from 1500 h on DAY 1 (after a fluid preload). With this reduction in body mass came expected reductions in urine volume and increased in urine colour, though trends in urine specific gravity were less pronounced. Blood pressure trended towards being lower during DAYS 1-3 and increased during DAY 4. Whole blood glucose concentrations also tended towards being lower during DAYS 1-3 compared to DAY 4, particularly postprandially. Hunger tended to be reduced during DAYS 1-3, but increased again during DAY 4. Wanting to eat appeared to be a separate construct to hunger/fullness. True-thirst was higher during DAYS 1-3 relative to DAY 4, and this synchronised well with true-xerostomia and ratings of dryness of lips. However, sensational-xerostomia was the dominant thirst experienced during DAY 1-3. Sadness was moderately inversely correlated with body mass loss (r = 0.57) and tiredness was strongly positively correlated (r = 0.94). Sleep quality was unrelated to hydration status. Conclusion: Overall, the expected changes occurred in terms of hydration physiology, but with some unexpected findings in terms of gluco-regulation, blood pressure, and thirst appetites.

scholarly journals It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis

2019 ◽  
Vol 4 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Jason P Appleton ◽  
Lisa J Woodhouse ◽  
Andrew Belcher ◽  
Daniel Bereczki ◽  
Eivind Berge ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Ischaemic Stroke ◽  
Glyceryl Trinitrate ◽  
Acute Stroke ◽  
Carotid Stenosis ◽  
Primary Outcome ◽  
Lower Blood ◽  
Bilateral Carotid ◽  
Using Data

BackgroundThere is concern that blood pressure (BP) lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis. We assessed the effect of glyceryl trinitrate (GTN) in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke (ENOS) Trial.MethodsENOS randomised 4011 patients with acute stroke and raised systolic BP (140–220 mm Hg) to transdermal GTN or no GTN within 48 hours of onset. Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days. The primary outcome was the modified Rankin Scale (mRS) at day 90. Ipsilateral carotid stenosis was split: <30%; 30–<50%; 50–<70%; ≥70%. Data are ORs with 95% CIs adjusted for baseline prognostic factors.Results2023 (60.5%) ischaemic stroke participants had carotid imaging. As compared with <30%, ≥70% ipsilateral stenosis was associated with an unfavourable shift in mRS (worse outcome) at 90 days (OR 1.88, 95% CI 1.44 to 2.44, p<0.001). Those with ≥70% stenosis who received GTN versus no GTN had a favourable shift in mRS (OR 0.56, 95% CI 0.34 to 0.93, p=0.024). In those with 50–<70% stenosis, continuing versus stopping prestroke antihypertensives was associated with worse disability, mood, quality of life and cognition at 90 days. Clinical outcomes did not differ across bilateral stenosis groups.ConclusionsFollowing ischaemic stroke, severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days. GTN appears safe in ipsilateral or bilateral carotid stenosis, and might improve outcome in severe ipsilateral carotid stenosis.

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