Moderate hypobaric hypoxia during a simulated 30 minutes airline travel induces alterations in the in the immune response

2017 ◽  
Author(s):  
Sylvia Kruse
Keyword(s):  
Immune Response ◽  
Hypobaric Hypoxia ◽  
Moderate Hypobaric Hypoxia ◽  
Airline Travel

Effects of moderate hypobaric hypoxia on evoked categorical visuocognitive responses

2008 ◽  
Vol 119 (7) ◽  
pp. 1475-1485 ◽  
Author(s):  
N. Tsarouchas ◽  
K. Benedek ◽  
A. Bezerianos ◽  
G. Benedek ◽  
S. Keri
Keyword(s):  
Hypobaric Hypoxia ◽  
Moderate Hypobaric Hypoxia

Hypoxia reduces airway epithelial sodium transport in rats

1999 ◽  
Vol 277 (5) ◽  
pp. L881-L886 ◽  
Author(s):  
L. A. Tomlinson ◽  
T. C. Carpenter ◽  
E. H. Baker ◽  
J. B. Bridges ◽  
J. V. Weil
Keyword(s):  
Sodium Transport ◽  
Hypobaric Hypoxia ◽  
Alveolar Epithelium ◽  
Airway Epithelial ◽  
Sprague Dawley ◽  
Edema Formation ◽  
Significant Fall ◽  
Moderate Hypobaric Hypoxia ◽  
Sprague Dawley Rats ◽  
Lung Liquid

Ascent to high altitude leads to pulmonary edema formation in some individuals. Recent laboratory evidence supports the hypothesis that hypoxia may impair the function of the alveolar epithelium and thus augment edema accumulation via reduced clearance of lung liquid. We investigated the effect of hypobaric hypoxia on epithelial sodium transport in adult Sprague-Dawley rats by measuring the nasal transepithelial potential difference (PD) as an index of airway sodium transport. Baseline PDs were similar to those previously reported in other species. Administration of amiloride resulted in a significant fall in nasal PD, as did ouabain administration for 24 h (−27.8 vs. −18.8 mV; P = 0.001; n = 5 rats). Exposure to hypobaric hypoxia (0.5 atm) for 24 h caused a significant fall in nasal PD (−23.7 vs. −18.8 mV; P = 0.002; n = 15 rats), which was not additive to the changes in nasal PD produced by amiloride or ouabain. We conclude that subacute exposure to moderate hypobaric hypoxia can inhibit sodium transport by the airway epithelium in rats.

scholarly journals Thirty Minutes of Hypobaric Hypoxia Provokes Alterations of Immune Response, Haemostasis, and Metabolism Proteins in Human Serum

2017 ◽  
Vol 18 (9) ◽  
pp. 1882 ◽  
Author(s):  
Jochen Hinkelbein ◽  
Stefanie Jansen ◽  
Ivan Iovino ◽  
Sylvia Kruse ◽  
Moritz Meyer ◽  
...  
Keyword(s):  
Immune Response ◽  
Human Serum ◽  
Hypobaric Hypoxia
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