HUMAN HERPESVIRUS 7 RELATED ACUTE ENCEPHALOPATHY WITH BIPHASIC SEIZURES AND LATE REDUCED DIFFUSION

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) develops in association with systemic as well as central nervous system (CNS) viral or bacterial infections. AESD is most often noted with influenza or human herpesvirus 6 infection in previously healthy infants. However, AESD has also been reported in an infant with developmental retardation and in a mentally and motor-disabled adolescent. Here, we report the case of a 4-year-old female with significant development delay due to spinal muscular atrophy, who developed AESD during Streptococcus sanguinis sepsis with no apparent CNS infection. Although the patient had extremely high serum procalcitonin (45.84 ng/mL, reference; <0.4) on admission indicating a poor prognosis, she was successfully managed for sepsis and AESD.

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Preferential involvement of U-fibers in human herpesvirus 6-associated acute encephalopathy

Annals of Neurology ◽

10.1002/1531-8249(199905)45:5<684::aid-ana24>3.0.co;2-a ◽

1999 ◽

Vol 45 (5) ◽

pp. 684-684 ◽

Cited By ~ 2

Author(s):

Yukiko Kurachi ◽

Yoichi Sakakihara ◽

Masaya Kubota ◽

Akira Oka ◽

Kuniya Hatakeyama ◽

...

Keyword(s):

Human Herpesvirus ◽

Acute Encephalopathy ◽

Human Herpesvirus 6 ◽

Herpesvirus 6

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Human Herpesvirus 7-Related Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion

The Pediatric Infectious Disease Journal ◽

10.1097/inf.0000000000002557 ◽

2020 ◽

Vol 39 (2) ◽

pp. 170-172

Author(s):

Garyfallia Syridou ◽

Ioannis Drikos ◽

Minas Kapetanakis ◽

Giorgos Vartzelis ◽

Elina Horefti ◽

...

Keyword(s):

Human Herpesvirus ◽

Acute Encephalopathy

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Human herpesvirus-6 infection-associated acute encephalopathy without skin rash

Brain and Development ◽

10.1016/j.braindev.2014.12.005 ◽

2015 ◽

Vol 37 (8) ◽

pp. 829-832 ◽

Cited By ~ 6

Author(s):

Shiho Yamamoto ◽

Satoru Takahashi ◽

Ryosuke Tanaka ◽

Akie Okayama ◽

Akiko Araki ◽

...

Keyword(s):

Skin Rash ◽

Human Herpesvirus ◽

Acute Encephalopathy ◽

Human Herpesvirus 6 ◽

Herpesvirus 6

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Acute Encephalopathy Following Exanthem Subitum Caused by Human Herpesvirus-6

Kansenshogaku zasshi ◽

10.11150/kansenshogakuzasshi1970.66.551 ◽

1992 ◽

Vol 66 (5) ◽

pp. 551-554 ◽

Cited By ~ 5

Author(s):

Takami SATO ◽

Toshiro INOUE ◽

Masato KAJIWARA ◽

Chiaki MIYAZAKI ◽

Koichi KUSUNOKI ◽

...

Keyword(s):

Human Herpesvirus ◽

Acute Encephalopathy ◽

Human Herpesvirus 6 ◽

Exanthem Subitum ◽

Herpesvirus 6

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Changes in Cerebrospinal Fluid Biomarkers in Human Herpesvirus-6-Associated Acute Encephalopathy/Febrile Seizures

Mediators of Inflammation ◽

10.1155/2014/564091 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 10

Author(s):

Naoyuki Tanuma ◽

Rie Miyata ◽

Keisuke Nakajima ◽

Akihisa Okumura ◽

Masaya Kubota ◽

...

Keyword(s):

Oxidative Stress ◽

Cerebrospinal Fluid ◽

Tau Protein ◽

Human Herpesvirus ◽

Febrile Seizures ◽

Acute Encephalopathy ◽

Human Herpesvirus 6 ◽

Control Subjects ◽

Significant Difference ◽

Herpesvirus 6

To determine the involvement of oxidative stress in the pathogenesis of acute encephalopathy associated with human herpesvirus-6 (HHV-6) infection, we measured the levels of oxidative stress markers 8-hydroxy-2′-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct (HEL), tau protein, and cytokines in cerebrospinal fluid (CSF) obtained from patients with HHV-6-associated acute encephalopathy (HHV-6 encephalopathy)(n=16)and complex febrile seizures associated with HHV-6 (HHV-6 complex FS)(n=10). We also examined changes in CSF-8OHdG and CSF-HEL levels in patients with HHV-6 encephalopathy before and after treatment with edaravone, a free radical scavenger. CSF-8-OHdG levels in HHV-6 encephalopathy and HHV-6 complex FS were significantly higher than in control subjects. In contrast, CSF-HEL levels showed no significant difference between groups. The levels of total tau protein in HHV-6 encephalopathy were significantly higher than in control subjects. In six patients with HHV-6 infection (5 encephalopathy and 1 febrile seizure), the CSF-8-OHdG levels of five patients decreased after edaravone treatment. Our results suggest that oxidative DNA damage is involved in acute encephalopathy associated with HHV-6 infection.

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