Role of Visual Evoked Potentials in Spatial dissemination for Multiple Sclerosis Diagnosis

Understanding the mechanisms underlying progression and developing new treatments for progressive multiple sclerosis (PMS) are among the major challenges in the field of central nervous system (CNS) demyelinating diseases. Over the last 10 years, also because of some technological advances, the visual pathways have emerged as a useful platform to study the processes of demyelination/remyelination and their relationship with axonal degeneration/protection. The wider availability and technological advances in optical coherence tomography (OCT) have allowed to add information on structural neuroretinal changes, in addition to functional information provided by visual evoked potentials (VEPs). The present review will address the role of the visual pathway as a platform to assess functional and structural damage in MS, focusing in particular on the role of VEPs and OCT, alone or in combination, in the prognosis and monitoring of PMS.

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Visual Evoked Potentials and Optical Coherence Tomography to characterize inflammation, demyelination and axonal loss in a preclinical model of Multiple Sclerosis

10.26226/morressier.5b31ec3a2afeeb001345a6b4 ◽

2018 ◽

Author(s):

Valerio Castoldi ◽

Silvia Marenna

Keyword(s):

Multiple Sclerosis ◽

Optical Coherence Tomography ◽

Evoked Potentials ◽

Visual Evoked Potentials ◽

Preclinical Model ◽

Axonal Loss ◽

Optical Coherence ◽

Visual Evoked

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Using advanced analysis of multifocal visual-evoked potentials to evaluate the risk of clinical progression in patients with radiologically isolated syndrome

Scientific Reports ◽

10.1038/s41598-021-81826-z ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

J. M. Miguel ◽

M. Roldán ◽

C. Pérez-Rico ◽

M. Ortiz ◽

L. Boquete ◽

...

Keyword(s):

Evoked Potentials ◽

Visual Evoked Potentials ◽

Area Under The Curve ◽

Multifocal Visual Evoked Potentials ◽

Radiologically Isolated Syndrome ◽

Advanced Analysis ◽

The Time Domain ◽

Visual Evoked

AbstractThis study aimed to assess the role of multifocal visual-evoked potentials (mfVEPs) as a guiding factor for clinical conversion of radiologically isolated syndrome (RIS). We longitudinally followed a cohort of 15 patients diagnosed with RIS. All subjects underwent thorough ophthalmological, neurological and imaging examinations. The mfVEP signals were analysed to obtain features in the time domain (SNRmin: amplitude, Latmax: monocular latency) and in the continuous wavelet transform (CWT) domain (bmax: instant in which the CWT function maximum appears, Nmax: number of CWT function maximums). The best features were used as inputs to a RUSBoost boosting-based sampling algorithm to improve the mfVEP diagnostic performance. Five of the 15 patients developed an objective clinical symptom consistent with an inflammatory demyelinating central nervous system syndrome during follow-up (mean time: 13.40 months). The (SNRmin) variable decreased significantly in the group that converted (2.74 ± 0.92 vs. 4.07 ± 0.95, p = 0.01). Similarly, the (bmax) feature increased significantly in RIS patients who converted (169.44 ± 24.81 vs. 139.03 ± 11.95 (ms), p = 0.02). The area under the curve analysis produced SNRmin and bmax values of 0.92 and 0.88, respectively. These results provide a set of new mfVEP features that can be potentially useful for predicting prognosis in RIS patients.

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Early disability in ambulatory patients with multiple sclerosis: optical coherence tomography versus visual evoked potentials, a comparative study

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-020-00204-0 ◽

2020 ◽

Vol 56 (1) ◽

Author(s):

Mohamed N. Thabit ◽

Mahmoud Mohamed Farouk ◽

Martha Awni ◽

Al-Amir Bassiouny Mohamed

Keyword(s):

Multiple Sclerosis ◽

Optical Coherence Tomography ◽

Comparative Study ◽

Evoked Potentials ◽

Visual Evoked Potentials ◽

Optical Coherence ◽

Ambulatory Patients ◽

Visual Evoked

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Complex pattern visual evoked potentials in controls and multiple sclerosis patients

10.1109/iembs.1989.96191 ◽

2003 ◽

Cited By ~ 3

Author(s):

J. Mitchell-DePew ◽

E. Micheli-Tzanakou

Keyword(s):

Multiple Sclerosis ◽

Evoked Potentials ◽

Visual Evoked Potentials ◽

Complex Pattern ◽

Pattern Visual Evoked Potentials ◽

Multiple Sclerosis Patients ◽

Visual Evoked

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Optical coherence tomography and visual evoked potentials: which is more sensitive in multiple sclerosis?

Multiple Sclerosis Journal ◽

10.1177/1352458514524293 ◽

2014 ◽

Vol 20 (10) ◽

pp. 1342-1347 ◽

Cited By ~ 34

Author(s):

Giovanni Di Maggio ◽

Roberto Santangelo ◽

Simone Guerrieri ◽

Mariangela Bianco ◽

Laura Ferrari ◽

...

Keyword(s):

Multiple Sclerosis ◽

Evoked Potentials ◽

Visual Evoked Potentials ◽

Retinal Nerve Fibre Layer ◽

Optic Coherence Tomography ◽

Rnfl Thickness ◽

Disability Status ◽

Increased Sensitivity ◽

Nerve Fibre Layer ◽

Visual Evoked

Objective: To assess the sensitivity of optic coherence tomography (OCT) and visual evoked potentials (VEPs) to visual pathway abnormalities in multiple sclerosis (MS). Methods: A total of 40 MS subjects, 28 with optic neuritis (ON) at least 3 months before (bilateral in 5), underwent assessment of visual acuity, Expanded Disability Status Scale (EDSS), OCT and VEPs, the latter quantified with a 0–4 conventional score. Results: OCT and VEPs were abnormal in 36% and 56% respectively in all eyes ( p=0.11), 68% and 86% in eyes with previous ON ( p=0.12), and in 19% versus 40% in eyes without ON history ( p=0.007). Combining VEP and OCT increased sensitivity to 89% in ON and 44% in non-ON eyes. Considering all eyes, global retinal nerve fibre layer (RNFL) thickness and VEP score were significantly correlated between them (ρ=−0.63, p<0.001) and with EDSS (RNFL: ρ=0.40, p<0.001; VEP score: ρ=0.47, p<0.001). Disease duration correlated with VEP score (ρ=0.25, p=0.025) and RNFL thickness (ρ=−0.71, p<0.001). Conclusions: In eyes without ON, VEPs were more frequently abnormal than OCT, while the two techniques showed similar sensitivity in eyes previously affected by ON. The correlation of VEPs and OCT measures with disability prompts further exploration of the two techniques as potential markers of disease burden.

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