INSUFFICIENT VARIATION OF MEDIUM CORPUSCULAR VOLUME (∆ MCV) IN INFLAMMATORY BOWEL DISEASE UNDER THYOPURINES PREDICTS DIFFICULTY IN ACHIEVING COMBINED DEEP REMISSION OUTCOME EVEN AFTER COMBINATION WITH Anti-TNF - THE OTHER SIDE OF The MCV flow study

2017 ◽  
Author(s):  
Joana Roseira
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
The Other ◽  
Corpuscular Volume ◽  
Inflammatory Bowel ◽  
Flow Study

Causal Association Between Atopic Dermatitis and Inflammatory Bowel Disease: A 2-Sample Bidirectional Mendelian Randomization Study

2021 ◽  
Author(s):  
Christa Meisinger ◽  
Dennis Freuer
Keyword(s):  
Inflammatory Bowel Disease ◽  
Atopic Dermatitis ◽  
Bowel Disease ◽  
Genome Wide Association Study ◽  
Mendelian Randomization ◽  
Causal Effect ◽  
The Other ◽  
Uk Biobank ◽  
Inflammatory Bowel ◽  
The Uk

Abstract Background Observational studies postulated an association between atopic dermatitis (AD) and inflammatory bowel disease (IBD). However, it remains unclear whether this relationship is causal. Methods To determine whether AD is causally related to IBD and vice versa, a 2-sample Mendelian randomization study was conducted. Independent genetic instruments from the largest available genome-wide association study for AD (EAGLE eczema consortium without the 23andMe study including 10,788 cases and 30,047 controls) were used to investigate the association with IBD in the UK Biobank study (7045 cases, 456,327 controls) and a second European IBD sample (12,882 cases, 21,770 controls). Results Atopic dermatitis was strongly associated with higher risk of IBD as a whole (odds ratio [OR], 1.107; 95% confidence interval [CI], 1.035; 1.183; P = .003) in the UK Biobank study. The positive association was not significant in the other IBD study (OR, 1.114; 95% CI, 0.956; 1.298), but in meta-analyses of results from the 2 studies, the strong association could be confirmed (OR, 1.11; 95% CI, 1.04; 1.18). When evaluating the causal relationship in the other direction, IBD as a whole did not show an association with AD. Subtype analyses revealed that AD was suggestively associated with ulcerative colitis (UC; OR, 1.149; 95% CI, 1.018; 1.297) but not Crohn’s disease (CD). However, there was a suggestive association between CD and AD (OR, 1.034; 95% CI, 1.004; 1.064) but not UC and AD. Conclusions This study supports a causal effect between AD and IBD—but not between IBD and AD. There seems to be considerable differences between UC and CD regarding their specific associations with AD. These findings have implications for the management of IBD and AD in clinical practice.

Surveillance in inflammatory bowel disease: an overview

2019 ◽  
Vol 17 (8) ◽  
pp. 32-37
Author(s):  
Sara Koo ◽  
Jignesh Jatania ◽  
Colin Rees
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Duration ◽  
The Other ◽  
Surveillance Colonoscopy ◽  
Targeted Biopsy ◽  
White Light Endoscopy ◽  
Increased Risk ◽  
Inflammatory Bowel

Patients with inflammatory bowel disease (IBD), including both ulcerative colitis and Crohn's disease, are at an increased risk of developing colorectal cancer. It is well accepted that this risk increases after 8–10 years of disease duration. Patients should be offered a surveillance colonoscopy after this time. Previously, white-light endoscopy with random biopsies every 10 cm was undertaken for surveillance, but recent evidence suggests that chromoendoscopy along with targeted biopsy is superior to this and the other available methods. This article reviews the available evidence for IBD surveillance, surveillance guidelines and the evidence for chromoendoscopy. Additionally, an overview of the assessment, reporting of any visible abnormal lesions and management of subsequently proven dysplastic lesions is given.

scholarly journals Absence of Effect of Somatostatin Analogue (SMS 201-995) in Diarrhea Associated with Inflammatory Bowel Disease

1989 ◽  
Vol 3 (2) ◽  
pp. 53-57 ◽  
Author(s):  
Richard N. Fedorak ◽  
Richard W. Sherbaniuk
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
The Other ◽  
Somatostatin Analogue ◽  
Intestinal Fluid ◽  
Anion Secretion ◽  
Severe Diarrhea ◽  
Electrolyte Absorption ◽  
Inflammatory Bowel ◽  
Long Acting

The octapeptide long acting somatostatin analogue, SMS 201-995 promotes intestinal fluid and electrolyte absorption and inhibits anion secretion. It is more potent than native somatostatin and does not exhibit tachyphylaxsis. SMS 201-995 was used to treat two patients with severe diarrhea associated with Crohn’s disease after other treatments had failed. The volume and frequency of ileostomy output in one patient and stool output in the other did not respond to therapy with SMS 201-995. ln fact, diarrhea appeared to increase in both patients while on treatment.

scholarly journals Two Cases of Pericarditis Associated with Inflammatory Bowel Disease

2005 ◽  
Vol 48 (1) ◽  
pp. 43-44 ◽  
Author(s):  
Bilge Tunc ◽  
Levent Filik ◽  
Aysel Ulker ◽  
Erkan Parlak
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Cardiac Disease ◽  
Bowel Disease ◽  
The Other ◽  
Intestinal Disease ◽  
Extraintestinal Manifestations ◽  
Extraintestinal Manifestation ◽  
Inflammatory Bowel ◽  
Cardiac Manifestations

Extraintestinal manifestations are common complications of inflammatory bowel disease (IBD) whereas the association of cardiac disease with IBD is rarely reported. Cardiac manifestations may be diagnosed before, concomitantly or after the diagnosis of the specific type of inflammatory bowel disease. Pericarditis and myocarditis are potentially serious complications. This extraintestinal manifestation developed in one patient concomitantly with onset of intestinal disease. One patient had ulcerative colitis (UC), while other had Crohn’s disease (CD). Indomethacin was effective in one and the other patient required prednisone in addition. Chest symptoms in patients with inflammatory bowel disease should be evaluated to exclude myopericardial disease.

scholarly journals Nem minden coeliakia, ami annak látszik. Coeliakia és gyulladásos bélbetegség együttes előfordulása

2015 ◽  
Vol 156 (26) ◽  
pp. 1059-1064
Author(s):  
István Tokodi
Keyword(s):  
Inflammatory Bowel Disease ◽  
Differential Diagnosis ◽  
Celiac Disease ◽  
Coeliac Disease ◽  
Bowel Disease ◽  
Gene Polymorphisms ◽  
The Other ◽  
Pathophysiological Mechanism ◽  
History Of ◽  
Inflammatory Bowel

The prevalence of inflammatory bowel disease is ten times more common in patients with celiac disease; however, studies investigating the reverse relation have contradictory findings. Many gene polymorphisms are known to be present in both diseases; furthermore, similarities observed in their pathophysiological mechanism, their family concomitance, results of the serologic analysis and their macroscopic and microscopic symptoms in the gastro-intestinal system suggest a relevant association between the two diseases. The author presents the history of four patients, of whom two had both Crohn’s and coeliac diseases. In the two other patients with inflammatory bowel disease the possible diagnosis of coeliac disease was suspected, but after additional examinations coeliac disease was excluded in one patient and seemed to be unlikely in the other patient. The author concludes that the differential diagnosis of the two diseases is not easy and if one of them is diagnosed, the possible presence of the other one should be taken into consideration. Orv. Hetil., 2015, 156(26), 1059–1064.

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