The antidepressant effects of a multimodal intervention including agomelatine correlate with circadian phase advance in youths with depression

2018 ◽  
Author(s):  
Joanne Carpenter
Keyword(s):  
Phase Advance ◽  
Multimodal Intervention ◽  
Circadian Phase ◽  
Antidepressant Effects

The antidepressant effects of a multimodal intervention including agomelatine correlate with circadian phase advance in youths with depression

2019 ◽  
Vol 29 ◽  
pp. S340-S341
Author(s):  
R. Robillard ◽  
J. Carpenter ◽  
K.L. Feilds ◽  
D. Hermens ◽  
D. White ◽  
...  
Keyword(s):  
Phase Advance ◽  
Multimodal Intervention ◽  
Circadian Phase ◽  
Antidepressant Effects

scholarly journals 0650 Study of the Effects of a 5 Hour and 8 Hour Circadian Phase Advance as a Model of Jet Lag Disorder

SLEEP ◽  
2018 ◽  
Vol 41 (suppl_1) ◽  
pp. A241-A241
Author(s):  
C M Polymeropoulos ◽  
E L Czeisler ◽  
M A Fisher ◽  
M H Polymeropoulos
Keyword(s):  
Phase Advance ◽  
Jet Lag ◽  
Circadian Phase

scholarly journals Chronic circadian phase advance in male mice induces depressive-like responses and suppresses neuroimmune activation

2021 ◽  
Vol 17 ◽  
pp. 100337
Author(s):  
Ruizhuo Chen ◽  
Aidan S. Weitzner ◽  
Lara A. McKennon ◽  
Laura K. Fonken
Keyword(s):  
Phase Advance ◽  
Male Mice ◽  
Circadian Phase ◽  
Neuroimmune Activation

Cocaine modulates pathways for photic and nonphotic entrainment of the mammalian SCN circadian clock

2012 ◽  
Vol 302 (6) ◽  
pp. R740-R750 ◽  
Author(s):  
J. David Glass ◽  
Allison J. Brager ◽  
Adam C. Stowie ◽  
Rebecca A. Prosser
Keyword(s):  
Circadian Clock ◽  
Receptor Antagonist ◽  
Serotonin Receptor ◽  
Activity Rhythm ◽  
Phase Shifts ◽  
Phase Delay ◽  
Phase Advance ◽  
Regulatory Pathways ◽  
Circadian Phase

Cocaine abuse is highly disruptive to circadian physiological and behavioral rhythms. The present study was undertaken to determine whether such effects are manifest through actions on critical photic and nonphotic regulatory pathways in the master circadian clock of the mouse suprachiasmatic nucleus (SCN). Impairment of SCN photic signaling by systemic (intraperitoneal) cocaine injection was evidenced by strong (60%) attenuation of light-induced phase-delay shifts of circadian locomotor activity during the early night. A nonphotic action of cocaine was apparent from its induction of 1-h circadian phase-advance shifts at midday. The serotonin receptor antagonist, metergoline, blocked shifting by 80%, implicating a serotonergic mechanism. Reverse microdialysis perfusion of the SCN with cocaine at midday induced 3.7 h phase-advance shifts. Control perfusions with lidocaine and artificial cerebrospinal fluid had little shifting effect. In complementary in vitro experiments, photic-like phase-delay shifts of the SCN circadian neuronal activity rhythm induced by glutamate application to the SCN were completely blocked by cocaine. Cocaine treatment of SCN slices alone at subjective midday, but not the subjective night, induced 3-h phase-advance shifts. Lidocaine had no shifting effect. Cocaine-induced phase shifts were completely blocked by metergoline, but not by the dopamine receptor antagonist, fluphenazine. Finally, pretreatment of SCN slices for 2 h with a low concentration of serotonin agonist (to block subsequent serotonergic phase resetting) abolished cocaine-induced phase shifts at subjective midday. These results reveal multiple effects of cocaine on adult circadian clock regulation that are registered within the SCN and involve enhanced serotonergic transmission.

Early evening melatonin and S-20098 advance circadian phase and nocturnal regulation of core body temperature

1997 ◽  
Vol 272 (4) ◽  
pp. R1178-R1188 ◽  
Author(s):  
K. Krauchi ◽  
C. Cajochen ◽  
D. Mori ◽  
P. Graw ◽  
A. Wirz-Justice
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Skin Temperature ◽  
Core Body Temperature ◽  
Phase Advance ◽  
Double Blind ◽  
Circadian Phase ◽  
Single Oral Administration ◽  
Dim Light ◽  
Core Body

The phase-shifting capacity and thermoregulatory effects of a single oral administration at 18 h of melatonin (5 mg) or S-20098, a melatonin agonist (5 or 100 mg), was investigated in eight healthy young men in a double-blind placebo crossover design. The unmasking conditions of a shortened constant-routine protocol (mini-CR) were used to collect evening phase markers of physiological parameters. In comparison to placebo, all three drug administrations induced an earlier dim-light melatonin onset (DLMO), an earlier increase in distal skin temperature, and an earlier decrease in core body temperature (CBT), heart rate, and proximal skin temperature. This indicates that administration at 18 h of both melatonin and S-20098 (more pronounced with 100 than 5 mg) induced an earlier regulation of the endogenous circadian nocturnal decline in CBT. On the posttreatment day a second mini-CR revealed persistent significantly phase-advanced circadian rhythms as estimated by DLMO, as well as by the midrange crossing time of CBT and heart rate decline. There were no significant differences between the two doses of S-20098. The data suggest that, in addition to immediate thermoregulatory changes, a phase advance of the circadian system had occurred and that the phase advance could still be measured on the posttreatment day.

Study of the effects of a 5 hour and 8 hour circadian phase advance as a model of JET Lag disorder

2019 ◽  
Vol 64 ◽  
pp. S304-S305
Author(s):  
C. Polymeropoulos ◽  
E. Czeisler ◽  
M. Fisher ◽  
G. Birznieks ◽  
C. Xiao ◽  
...  
Keyword(s):  
Phase Advance ◽  
Jet Lag ◽  
Circadian Phase

Antidepressant effects of the sleep/wake cycle phase advance

1987 ◽  
Vol 12 (1) ◽  
pp. 41-46 ◽  
Author(s):  
E. Souêtre ◽  
E. Salvati ◽  
D. Pringuey ◽  
Y. Plasse ◽  
M. Savelli ◽  
...  
Keyword(s):  
Phase Advance ◽  
Cycle Phase ◽  
Antidepressant Effects

Morning bright light therapy: a helpful tool for reducing comorbid symptoms of affective and behavioral dysregulation in juvenile depressed inpatients? A pilot trial

2017 ◽  
Vol 45 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Sarah Bogen ◽  
Tanja Legenbauer ◽  
Stephanie Gest ◽  
Martin Holtmann
Keyword(s):  
Pilot Trial ◽  
Secondary Analysis ◽  
Bright Light ◽  
Light Therapy ◽  
Bright Light Therapy ◽  
Circadian Phase ◽  
Behavioral Dysregulation ◽  
Sleep Parameters ◽  
Circadian Effect ◽  
Dysregulation Profile

Abstract. Objective: In recent years, bright light therapy (BLT) has been used to treat depression and to stabilize circadian rhythms. In this study we evaluated whether it is also helpful for comorbid symptoms of affective and behavioral dysregulation in depressive inpatients. Method: This article reports a secondary analysis comparing two subgroups of depressive participants with comorbid affective and behavioral dysregulation, captured with the dysregulation-profile of the Strengths and Difficulties Questionnaire (SDQ-DP; n = 16 vs. n = 11). Participants were randomly allocated to active BLT (10,000 lux) or control BLT (approx. 100 lux), and received 45 minutes of BLT for 2 weeks. SDQ-DP scores, sleep parameters, and circadian preference were assessed at baseline, after the intervention, and 3 weeks later. Results: No direct effects on SDQ-DP scores were observed. Sleep improved in both conditions. Only in the active BLT condition was a circadian phase advance found. Correlation and regression analyses indicated an indirect, circadian effect for improved SDQ-DP scores. Conclusions: The data of this pilot trial should be considered preliminary and merely descriptive. Further research is warranted.


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