Morning bright light therapy: a helpful tool for reducing comorbid symptoms of affective and behavioral dysregulation in juvenile depressed inpatients? A pilot trial

Author(s):  
Sarah Bogen ◽  
Tanja Legenbauer ◽  
Stephanie Gest ◽  
Martin Holtmann

Abstract. Objective: In recent years, bright light therapy (BLT) has been used to treat depression and to stabilize circadian rhythms. In this study we evaluated whether it is also helpful for comorbid symptoms of affective and behavioral dysregulation in depressive inpatients. Method: This article reports a secondary analysis comparing two subgroups of depressive participants with comorbid affective and behavioral dysregulation, captured with the dysregulation-profile of the Strengths and Difficulties Questionnaire (SDQ-DP; n = 16 vs. n = 11). Participants were randomly allocated to active BLT (10,000 lux) or control BLT (approx. 100 lux), and received 45 minutes of BLT for 2 weeks. SDQ-DP scores, sleep parameters, and circadian preference were assessed at baseline, after the intervention, and 3 weeks later. Results: No direct effects on SDQ-DP scores were observed. Sleep improved in both conditions. Only in the active BLT condition was a circadian phase advance found. Correlation and regression analyses indicated an indirect, circadian effect for improved SDQ-DP scores. Conclusions: The data of this pilot trial should be considered preliminary and merely descriptive. Further research is warranted.


2017 ◽  
Vol 91 ◽  
pp. 105-110 ◽  
Author(s):  
Rachel E. Fargason ◽  
Aaron D. Fobian ◽  
Lauren M. Hablitz ◽  
Jodi R. Paul ◽  
Brittny A. White ◽  
...  

Author(s):  
Inken Kirschbaum-Lesch ◽  
Stephanie Gest ◽  
Tanja Legenbauer ◽  
Martin Holtmann

Abstract. Objective: Bright light therapy (BLT) has recently come into increasing focus in the treatment of adolescent depression, whereby light glasses today appear to be more feasible than light therapy boxes. This study investigated the feasibility and efficacy of 4 weeks of BLT with light glasses. It also analyzed whether a treatment duration of 4 weeks of BLT yields larger effects than the 2 weeks of BLT investigated in previous studies. Methods: This first open-label, single-arm, prospective clinical trial pursued a naturalistic approach: 39 inpatients aged 12–18 years with moderate or severe depression received 4 weeks of morning BLT with light glasses in addition to usual treatment. Depressive symptoms, sleep problems, circadian phase, and the clinical global impression were assessed at several timepoints. In a second analysis, the data of the present study were compared to those from a previous pilot trial. Results: Depressive symptoms, sleep problems, and the global clinical impression improved significantly after BLT with light glasses, whereas the circadian phase did not change over time. Light glasses showed similarly positive effects on sleep parameters and depressive symptoms as light boxes. Contrary to expectation, prolonging BLT to 4 weeks did not yield larger effects on depressive symptoms and sleep complaints compared to 2 weeks of intervention. Conclusions: Light glasses seem to be a feasible and highly acceptable method for the treatment of adolescent depression. Further randomized controlled trials are needed to obtain sufficient evidence regarding the efficacy of BLT as an add-on intervention to psychological and pharmacological approaches for adolescent depression.


PLoS ONE ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. e0230839
Author(s):  
Mark J. Eisenberg ◽  
Bettina Habib ◽  
Maria Alcaraz ◽  
Brett D. Thombs ◽  
Kristian B. Filion

Neurology ◽  
2019 ◽  
pp. 10.1212/WNL.0000000000007090 ◽  
Author(s):  
Sonja Rutten ◽  
Chris Vriend ◽  
Jan H. Smit ◽  
Henk W. Berendse ◽  
Eus J.W. van Someren ◽  
...  

2021 ◽  
Author(s):  
Canazei Markus ◽  
Weninger Johannes ◽  
Pohl Wilfried ◽  
Marksteiner Josef ◽  
Weiss Elisabeth

Abstract Bright light therapy is an effective treatment option for seasonal and non-seasonal affective disorders. However up to now, no study has investigated effects of dynamic bedroom lighting in hospitalized patients with major depression. A bedroom lighting system, which automatically delivered artificial dawn and dusk and blue-depleted nighttime lighting (DD-N lighting) was installed in a psychiatric ward. Patients with moderate to severe depression were randomly assigned to stay in bedrooms with the new lighting or standard lighting system. Patients wore wrist actimeters during the first two treatment weeks. Additionally, hospitalization duration and daily psychotropic medication were retrieved from patients’ medical charts. Data from thirty patients were analyzed. Patients under DD-N lighting generally woke up earlier (+20 minutes), slept longer (week 1: +11 min; week 2: +27 min) and showed higher sleep efficiency (+2.4%) and shorter periods of nighttime awakenings (-15 minutes). In the second treatment week, patients started sleep and the most active 10-hour period earlier (-33 min and -64 min, respectively). This pilot study gives first evidence that depressed patients’ sleep and circadian rest/activity system may benefit from adjunctive bedroom lighting when starting inpatient treatment.


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