Implementation of Sentinel Lymph Node Mapping Using ICG and Near-Infrared Fluorescence in Patient with Early Stage Vulvar Cancer

2019 ◽  
Author(s):  
Payam Kashi
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Near Infrared ◽  
Vulvar Cancer ◽  
Early Stage ◽  
Sentinel Lymph Node Mapping ◽  
Near Infrared Fluorescence ◽  
Lymph Node Mapping

scholarly journals Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging

2014 ◽  
Vol 110 (7) ◽  
pp. 845-850 ◽  
Author(s):  
B.E. Schaafsma ◽  
F.P.R. Verbeek ◽  
H.W. Elzevier ◽  
Q.R.J.G. Tummers ◽  
J.R. van der Vorst ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Sentinel Lymph Node Mapping ◽  
Near Infrared Fluorescence ◽  
Lymph Node Mapping ◽  
Near Infrared Fluorescence Imaging

scholarly journals Dose optimization for near-infrared fluorescence sentinel lymph node mapping in patients with melanoma

2012 ◽  
Vol 168 (1) ◽  
pp. 93-98 ◽  
Author(s):  
J.R. van der Vorst ◽  
B.E. Schaafsma ◽  
F.P.R. Verbeek ◽  
R.J. Swijnenburg ◽  
M. Hutteman ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Near Infrared ◽  
Sentinel Lymph Node Mapping ◽  
Dose Optimization ◽  
Near Infrared Fluorescence ◽  
Lymph Node Mapping

scholarly journals Sentinel Lymph Node Biopsy in Vulvar Cancer Using Combined Radioactive and Fluorescence Guidance

2015 ◽  
Vol 25 (6) ◽  
pp. 1086-1093 ◽  
Author(s):  
Floris P.R. Verbeek ◽  
Quirijn R.J.G. Tummers ◽  
Daphne D.D. Rietbergen ◽  
Alexander A.W. Peters ◽  
Boudewijn E. Schaafsma ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Near Infrared ◽  
Vulvar Cancer ◽  
Intraoperative Imaging ◽  
Sentinel Lymph Node Mapping ◽  
Lymph Node Biopsy ◽  
Blue Dye ◽  
Lymph Node Mapping ◽  
Nir Fluorescence

ObjectiveNear-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has recently been introduced to improve the sentinel lymph node (SLN) procedure. Several optical tracers have been successfully tested. However, the optimal tracer formulation is still unknown. This study evaluates the performance of ICG–technetium-99m (99mTc)–nanocolloid in relation to 2 most commonly used ICG-based formulas during SLN biopsy in vulvar cancer.Methods and MaterialsTwelve women who planned to undergo SLN biopsy for stage I vulvar cancer were prospectively included. Sentinel lymph node mapping was performed using the dual-modality radioactive and NIR fluorescence tracer ICG–99mTc-nanocolloid. All patients underwent combined SLN localization using NIR fluorescence and the (current) gold standard using blue dye and radioactive guidance.ResultsIn all 12 patients, at least 1 SLN was detected during surgery. A total of 21 lymph nodes (median 2; range, 1–3) were resected. Median time between skin incision and first SLN detection was 8 (range, 1–22) minutes. All resected SLNs were both radioactive and fluorescent, although only 13 (62%) of 21 SLNs stained blue. Median brightness of exposed SLNs, expressed as signal-to-background ratio, was 5.4 (range, 1.8–11.8). Lymph node metastases were found in 3 patients.ConclusionsNear-infrared fluorescence-guided SLN mapping is feasible and outperforms blue dye staining. Premixing ICG with 99mTc-nanocolloid provides real-time intraoperative imaging of the SN and seems to be the optimal tracer combination in terms of intraoperative detection rate of the SN (100%). Moreover, ICG–99mTc-nanocolloid allows the administration of a 5-times lower injected dose of ICG (compared with ICG and ICG absorbed to human serum albumin) and can be injected up to 20 hours before surgery.

55. Near-infrared fluorescence sentinel lymph node mapping in patients with muscle-invasive bladder cancer

2014 ◽  
Vol 40 (11) ◽  
pp. S30 ◽  
Author(s):  
H.J.M. Handgraaf ◽  
B.E. Schaafsma ◽  
F.P.R. Verbeek ◽  
H.W. Elzevier ◽  
Q.R.J.G. Tummers ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Near Infrared ◽  
Sentinel Lymph Node Mapping ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Near Infrared Fluorescence ◽  
Lymph Node Mapping ◽  
Muscle Invasive
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